WSCD1_HUMAN
ID WSCD1_HUMAN Reviewed; 575 AA.
AC Q658N2; A8K0N8; D3DTM3; O60276; Q96G45;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=WSC domain-containing protein 1;
GN Name=WSCD1; Synonyms=KIAA0523;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Stomach;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT TYR-212.
RC TISSUE=Muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 108-575.
RC TISSUE=Brain;
RX PubMed=9628581; DOI=10.1093/dnares/5.1.31;
RA Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N.,
RA Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. IX. The
RT complete sequences of 100 new cDNA clones from brain which can code for
RT large proteins in vitro.";
RL DNA Res. 5:31-39(1998).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the WSCD family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK289603; BAF82292.1; -; mRNA.
DR EMBL; AL833730; CAH56249.1; -; mRNA.
DR EMBL; CH471108; EAW90316.1; -; Genomic_DNA.
DR EMBL; CH471108; EAW90317.1; -; Genomic_DNA.
DR EMBL; BC009975; AAH09975.1; -; mRNA.
DR EMBL; AB011095; BAA25449.1; -; mRNA.
DR CCDS; CCDS32538.1; -.
DR RefSeq; NP_056068.1; NM_015253.1.
DR RefSeq; XP_005256629.1; XM_005256572.1.
DR RefSeq; XP_005256630.1; XM_005256573.1.
DR AlphaFoldDB; Q658N2; -.
DR SMR; Q658N2; -.
DR STRING; 9606.ENSP00000460825; -.
DR GlyGen; Q658N2; 2 sites.
DR iPTMnet; Q658N2; -.
DR PhosphoSitePlus; Q658N2; -.
DR BioMuta; WSCD1; -.
DR DMDM; 74724420; -.
DR MassIVE; Q658N2; -.
DR PaxDb; Q658N2; -.
DR PeptideAtlas; Q658N2; -.
DR PRIDE; Q658N2; -.
DR ProteomicsDB; 65923; -.
DR Antibodypedia; 2667; 11 antibodies from 8 providers.
DR DNASU; 23302; -.
DR Ensembl; ENST00000317744.10; ENSP00000323087.5; ENSG00000179314.16.
DR Ensembl; ENST00000574232.5; ENSP00000458374.1; ENSG00000179314.16.
DR Ensembl; ENST00000574946.5; ENSP00000460825.1; ENSG00000179314.16.
DR GeneID; 23302; -.
DR KEGG; hsa:23302; -.
DR MANE-Select; ENST00000317744.10; ENSP00000323087.5; NM_015253.2; NP_056068.1.
DR UCSC; uc002gcn.4; human.
DR CTD; 23302; -.
DR DisGeNET; 23302; -.
DR GeneCards; WSCD1; -.
DR HGNC; HGNC:29060; WSCD1.
DR HPA; ENSG00000179314; Tissue enhanced (brain).
DR MIM; 619584; gene.
DR neXtProt; NX_Q658N2; -.
DR OpenTargets; ENSG00000179314; -.
DR PharmGKB; PA162409253; -.
DR VEuPathDB; HostDB:ENSG00000179314; -.
DR eggNOG; KOG4157; Eukaryota.
DR GeneTree; ENSGT00940000158096; -.
DR InParanoid; Q658N2; -.
DR OMA; KDFEPFT; -.
DR OrthoDB; 809004at2759; -.
DR PhylomeDB; Q658N2; -.
DR TreeFam; TF324060; -.
DR PathwayCommons; Q658N2; -.
DR BioGRID-ORCS; 23302; 9 hits in 1065 CRISPR screens.
DR ChiTaRS; WSCD1; human.
DR GenomeRNAi; 23302; -.
DR Pharos; Q658N2; Tdark.
DR PRO; PR:Q658N2; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q658N2; protein.
DR Bgee; ENSG00000179314; Expressed in ventricular zone and 147 other tissues.
DR ExpressionAtlas; Q658N2; baseline and differential.
DR Genevisible; Q658N2; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0008146; F:sulfotransferase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR InterPro; IPR002889; WSC_carb-bd.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR Pfam; PF01822; WSC; 2.
DR SMART; SM00321; WSC; 2.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51212; WSC; 2.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..575
FT /note="WSC domain-containing protein 1"
FT /id="PRO_0000305061"
FT TRANSMEM 15..35
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 142..234
FT /note="WSC 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00558"
FT DOMAIN 245..340
FT /note="WSC 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00558"
FT CARBOHYD 257
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 348
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 212
FT /note="H -> Y (in dbSNP:rs17855415)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_035160"
SQ SEQUENCE 575 AA; 65694 MW; A672F406EFDE849B CRC64;
MAKPFFRLQK FLRRTQFLLF FLTAAYLMTG SLLLLQRVRV ALPQGPRAPG PLQTLPVAAV
ALGVGLLDSR ALHDPRVSPE LLLGVDMLQS PLTRPRPGPR WLRSRNSELR QLRRRWFHHF
MSDSQGPPAL GPEAARPAIH SRGTYIGCFS DDGHERTLKG AVFYDLRKMT VSHCQDACAE
RSYVYAGLEA GAECYCGNRL PAVSVGLEEC NHECKGEKGS VCGAVDRLSV YRVDELQPGS
RKRRTATYRG CFRLPENITH AFPSSLIQAN VTVGTCSGFC SQKEFPLAIL RGWECYCAYP
TPRFNLRDAM DSSVCGQDPE AQRLAEYCEV YQTPVQDTRC TDRRFLPNKS KVFVALSSFP
GAGNTWARHL IEHATGFYTG SYYFDGTLYN KGFKGEKDHW RSRRTICVKT HESGRREIEM
FDSAILLIRN PYRSLVAEFN RKCAGHLGYA ADRNWKSKEW PDFVNSYASW WSSHVLDWLK
YGKRLLVVHY EELRRSLVPT LREMVAFLNV SVSEERLLCV ENNKEGSFRR RGRRSHDPEP
FTPEMKDLIN GYIRTVDQAL RDHNWTGLPR EYVPR
