ID   WSCD1_RAT               Reviewed;         572 AA.
AC   Q505J3;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=WSC domain-containing protein 1;
GN   Name=Wscd1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the WSCD family. {ECO:0000305}.
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DR   EMBL; BC094520; AAH94520.1; -; mRNA.
DR   RefSeq; NP_001019405.1; NM_001024234.1.
DR   RefSeq; XP_017452591.1; XM_017597102.1.
DR   RefSeq; XP_017452592.1; XM_017597103.1.
DR   RefSeq; XP_017452593.1; XM_017597104.1.
DR   RefSeq; XP_017452594.1; XM_017597105.1.
DR   RefSeq; XP_017452595.1; XM_017597106.1.
DR   RefSeq; XP_017452596.1; XM_017597107.1.
DR   RefSeq; XP_017452597.1; XM_017597108.1.
DR   RefSeq; XP_017452598.1; XM_017597109.1.
DR   AlphaFoldDB; Q505J3; -.
DR   SMR; Q505J3; -.
DR   STRING; 10116.ENSRNOP00000010358; -.
DR   GlyGen; Q505J3; 3 sites.
DR   iPTMnet; Q505J3; -.
DR   PhosphoSitePlus; Q505J3; -.
DR   PaxDb; Q505J3; -.
DR   Ensembl; ENSRNOT00000010358; ENSRNOP00000010358; ENSRNOG00000007869.
DR   GeneID; 287466; -.
DR   KEGG; rno:287466; -.
DR   UCSC; RGD:1308212; rat.
DR   CTD; 23302; -.
DR   RGD; 1308212; Wscd1.
DR   eggNOG; KOG4157; Eukaryota.
DR   GeneTree; ENSGT00940000158096; -.
DR   InParanoid; Q505J3; -.
DR   OMA; KDFEPFT; -.
DR   OrthoDB; 809004at2759; -.
DR   PhylomeDB; Q505J3; -.
DR   TreeFam; TF324060; -.
DR   PRO; PR:Q505J3; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000007869; Expressed in Ammon's horn and 19 other tissues.
DR   Genevisible; Q505J3; RN.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008146; F:sulfotransferase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000863; Sulfotransferase_dom.
DR   InterPro; IPR002889; WSC_carb-bd.
DR   Pfam; PF00685; Sulfotransfer_1; 1.
DR   Pfam; PF01822; WSC; 2.
DR   SMART; SM00321; WSC; 2.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51212; WSC; 2.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Repeat; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..572
FT                   /note="WSC domain-containing protein 1"
FT                   /id="PRO_0000305063"
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          139..231
FT                   /note="WSC 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00558"
FT   DOMAIN          242..337
FT                   /note="WSC 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00558"
FT   REGION          116..135
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        105
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        254
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        345
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   572 AA;  64789 MW;  C838CB1C31C24634 CRC64;
     MAKPFFRLQK FLRRTQFLLL FLTAAYLMTG SLLLLQRARV ALPQALRAPG SLQALPVATV
     ALGVGLLDSR SLHDPHSSPD LLLDVDTLRS PLARVPPGIR WPRRNRSSLR RRWLHHLTSD
     PQGPPTLGPE ASGPASHNQG NYLGCFSEEG QERTLKGAVF YDLRKMTVSH CQEACAERSY
     VYAGLEAGAE CYCGNRLPAT RVSLKECNQE CKGEKGSMCG ALHRLSVYSV GLQQSGAKKR
     WTATYRGCFP LPENITRTFS SSMTQANVTV ETCSGFCSQK EFPLAILRGW ACYCAYPTPQ
     FSLRDAVDGA LCSQGTEAQG LPGYCEVYQT PVQDTRCTDR KFLPNKSKVF VALSSFPGAG
     NTWARHLIEH ATGFYTGSYY FDGTLYNKGF KGEKDHWRSR RTICVKTHES GRREIEMFDS
     AILLIRNPYR SLVAEFNRKC AGHLGYAPDR NWKSKEWPDF VNSYASWWSS HVLDWLKYGK
     RLLVVHYEEL RHSLVPTLRE MVAFLNVSVS EERLLCVENN KEGSFRRRGR HPHDQEPFTP
     EMKDLINGYI RTVDQALRDH NWAGLPREYV PR