ID   WSCD1_XENTR             Reviewed;         573 AA.
AC   Q0IIY2;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=WSC domain-containing protein 1;
GN   Name=wscd1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the WSCD family. {ECO:0000305}.
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DR   EMBL; BC121480; AAI21481.1; -; mRNA.
DR   RefSeq; NP_001072375.1; NM_001078907.1.
DR   AlphaFoldDB; Q0IIY2; -.
DR   SMR; Q0IIY2; -.
DR   PaxDb; Q0IIY2; -.
DR   DNASU; 779828; -.
DR   GeneID; 779828; -.
DR   KEGG; xtr:779828; -.
DR   CTD; 23302; -.
DR   Xenbase; XB-GENE-5802595; wscd1.
DR   eggNOG; KOG4157; Eukaryota.
DR   InParanoid; Q0IIY2; -.
DR   OrthoDB; 809004at2759; -.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008146; F:sulfotransferase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000863; Sulfotransferase_dom.
DR   InterPro; IPR002889; WSC_carb-bd.
DR   Pfam; PF00685; Sulfotransfer_1; 1.
DR   Pfam; PF01822; WSC; 2.
DR   SMART; SM00321; WSC; 2.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51212; WSC; 2.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Repeat; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..573
FT                   /note="WSC domain-containing protein 1"
FT                   /id="PRO_0000305064"
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          136..228
FT                   /note="WSC 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00558"
FT   DOMAIN          239..332
FT                   /note="WSC 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00558"
FT   CARBOHYD        239
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        251
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        262
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        312
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        315
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        562
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   573 AA;  65909 MW;  F3A958B42D648A96 CRC64;
     MAKPFFSLQK FLRRAQFFLF FLTVAYLMAG SLLLLQRSYL VIQQSNRGTV GNLGLSADSV
     GDQYIDHRMV PKGLAKLHAK NLLTQRHGVI DQPLWLITRN SELRQLRRRW FHNFVKDQDP
     SLGTPSKVVK HMLVNKGTYV GCFVDNAEKR TLKATVFFDL RKMTVSHCQD ACAERTYVYA
     GLAYGSECYC GNHLPLNRAK EEECNNECKG EKGSVCGGVN RLSVFRLEDL HVSAKQRRNV
     TYRGCFRAPE NVTRIFPVSF PNLTVEMCSE FCSDKEYPLA IVKWTECFCG YPTGQFNLYE
     PLDESLCAGY LNGTNESEAL REENYCSVYQ TPIQDTRCTD RKFLPIKSKV FIALSSFPGA
     GNTWVRHLIE HATGYYTGSY YFDGTLYNKG FKGEKDHWRS GRTICVKTHE SGKREIEMYD
     SSILLIRNPY KALIAEFNRK CGGHLGYATE KHWTSREWPE FVNSYASWWA SHALDWLQYG
     RKLLVVHYED LKMDLIGKLR EMLAFLKVPI NEDRLLCVEN NKDGNFKRLG SSQSSLEPFT
     QEMKNVIDGY IRTVDKALKA RNFSGLPEEY MPR