WSCD2_DANRE
ID WSCD2_DANRE Reviewed; 572 AA.
AC A2BGL3;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=WSC domain-containing protein 2;
GN Name=wscd2; ORFNames=si:ch211-240b21.1;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the WSCD family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BX510312; CAM14122.1; -; Genomic_DNA.
DR RefSeq; NP_001103239.1; NM_001109769.1.
DR AlphaFoldDB; A2BGL3; -.
DR SMR; A2BGL3; -.
DR STRING; 7955.ENSDARP00000083072; -.
DR PaxDb; A2BGL3; -.
DR Ensembl; ENSDART00000088639; ENSDARP00000083072; ENSDARG00000061819.
DR GeneID; 561091; -.
DR KEGG; dre:561091; -.
DR CTD; 9671; -.
DR ZFIN; ZDB-GENE-060526-124; wscd2.
DR eggNOG; KOG4157; Eukaryota.
DR GeneTree; ENSGT00940000159434; -.
DR HOGENOM; CLU_029239_0_0_1; -.
DR InParanoid; A2BGL3; -.
DR OMA; ECKGERS; -.
DR OrthoDB; 809004at2759; -.
DR PhylomeDB; A2BGL3; -.
DR TreeFam; TF324060; -.
DR PRO; PR:A2BGL3; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 5.
DR Bgee; ENSDARG00000061819; Expressed in heart and 14 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0008146; F:sulfotransferase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR InterPro; IPR002889; WSC_carb-bd.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR Pfam; PF01822; WSC; 2.
DR SMART; SM00321; WSC; 2.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51212; WSC; 2.
PE 3: Inferred from homology;
KW Glycoprotein; Membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..572
FT /note="WSC domain-containing protein 2"
FT /id="PRO_0000305066"
FT TRANSMEM 19..39
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 134..226
FT /note="WSC 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00558"
FT DOMAIN 237..331
FT /note="WSC 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00558"
FT CARBOHYD 196
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 249
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 262
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 561
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 572 AA; 65023 MW; 35BFD3293A1425F0 CRC64;
MARSLLKIHR YFRRKPVRFF SFILLYLTAG SLVFLHSGFS SDSSTAGIAG SGSDPLLSEG
RGGTGGGSAT SEGLGLLGRV FKETRRTPRR FGPPWMKESR GQDAPEWAGR GFDHTSSWSH
GAKGRTTKEM DDGRAKYIGC YVDDTQKRAL RGVSFLDYKK MTVFRCQDNC AERGYLYAGL
EFGAECYCGH KIQAPNVSES ECNMECKGEK SNLCGGPNRL SIYRLELSQE SARRYGSAIF
KGCFRRPDNV TLALPASAVM QNMSVDKCVD MCTEKEFSLA ALAGDKCHCG FPTPLFNLHE
HEDEELCLHR CTGEDFESCG NRDFFVVYQT QVQDNRCMDR RFLPTRSKHL MALASFPGAG
NTWARHLIEL ATGYYTGSYY FDGSLYNKGF KGERDHWRSG RTICIKTHES GKKEIETFDA
SILMIRNPYK ALMAEFNRKY GGHIGFASQA HWRGKEWPEF VKNYAPWWAS HTLDWLKYGK
KVQVVHFEDL KRDLFSQLKG MVIFLGLEVS EDRLLCVEGQ KDGNFKRSGL RKLEYDPYTV
EMRATIDRLI KTVDMELRKR NLSGVPDEYR PR
