WSDU1_MOUSE
ID WSDU1_MOUSE Reviewed; 474 AA.
AC Q9D0I6; Q80X63;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=WD repeat, SAM and U-box domain-containing protein 1;
GN Name=Wdsub1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Olfactory epithelium, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH50792.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK011391; BAB27588.1; -; mRNA.
DR EMBL; AL929242; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC050792; AAH50792.1; ALT_INIT; mRNA.
DR EMBL; BC061948; AAH61948.1; -; mRNA.
DR CCDS; CCDS16055.1; -.
DR RefSeq; NP_001153108.1; NM_001159636.1.
DR RefSeq; NP_082394.1; NM_028118.2.
DR RefSeq; XP_006500286.1; XM_006500223.3.
DR AlphaFoldDB; Q9D0I6; -.
DR SMR; Q9D0I6; -.
DR BioGRID; 215176; 1.
DR STRING; 10090.ENSMUSP00000028368; -.
DR PhosphoSitePlus; Q9D0I6; -.
DR EPD; Q9D0I6; -.
DR MaxQB; Q9D0I6; -.
DR PaxDb; Q9D0I6; -.
DR PRIDE; Q9D0I6; -.
DR ProteomicsDB; 297566; -.
DR Antibodypedia; 33718; 113 antibodies from 20 providers.
DR Ensembl; ENSMUST00000028368; ENSMUSP00000028368; ENSMUSG00000026988.
DR GeneID; 72137; -.
DR KEGG; mmu:72137; -.
DR UCSC; uc008jto.2; mouse.
DR CTD; 151525; -.
DR MGI; MGI:1919387; Wdsub1.
DR VEuPathDB; HostDB:ENSMUSG00000026988; -.
DR eggNOG; KOG4155; Eukaryota.
DR GeneTree; ENSGT00940000157230; -.
DR HOGENOM; CLU_038099_0_0_1; -.
DR InParanoid; Q9D0I6; -.
DR OMA; AWLCAQD; -.
DR OrthoDB; 957291at2759; -.
DR PhylomeDB; Q9D0I6; -.
DR TreeFam; TF328991; -.
DR BioGRID-ORCS; 72137; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Wdsub1; mouse.
DR PRO; PR:Q9D0I6; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q9D0I6; protein.
DR Bgee; ENSMUSG00000026988; Expressed in olfactory epithelium and 227 other tissues.
DR ExpressionAtlas; Q9D0I6; baseline and differential.
DR Genevisible; Q9D0I6; MM.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR Gene3D; 1.10.150.50; -; 1.
DR Gene3D; 2.130.10.10; -; 3.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR003613; Ubox_domain.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR Pfam; PF07647; SAM_2; 1.
DR Pfam; PF04564; U-box; 1.
DR Pfam; PF00400; WD40; 7.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00454; SAM; 1.
DR SMART; SM00504; Ubox; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF47769; SSF47769; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
DR PROSITE; PS51698; U_BOX; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Phosphoprotein; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..474
FT /note="WD repeat, SAM and U-box domain-containing protein
FT 1"
FT /id="PRO_0000278609"
FT REPEAT 10..47
FT /note="WD 1"
FT REPEAT 52..91
FT /note="WD 2"
FT REPEAT 95..134
FT /note="WD 3"
FT REPEAT 137..176
FT /note="WD 4"
FT REPEAT 178..227
FT /note="WD 5"
FT REPEAT 236..275
FT /note="WD 6"
FT REPEAT 278..317
FT /note="WD 7"
FT DOMAIN 330..394
FT /note="SAM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00184"
FT DOMAIN 401..474
FT /note="U-box"
FT MOD_RES 456
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8N9V3"
FT CONFLICT 423
FT /note="D -> G (in Ref. 3; AAH50792)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 474 AA; 51691 MW; A8C49D032D562167 CRC64;
MVRLIHTLAD HGDDVSCCAF SAALLATCSL DKTIRLYSLS DFAELPYSPL KFHTYAVHCC
CFSPSGHVLA SCSTDGTTVL WSSHSGHTLT VLEQPGGSPV RVCCFSPDSA YLASGAADGS
IALWNAQTYK LYRCGSVKDS SLVACAFSPD GGLFVTGSSG GDLTVWDDRM RCLHSEKAHD
LGITCCSFSS QPLSGGEGLQ SYQLASCGQD CEIKLWAVTI TRVLGFELKY KSTLSGHCAP
VLACAFSHDG KMLASGSVDK SVIIHGIGPQ SVLHTLTQHT RYVTTCAFAP NTLLLATGSM
DKTVNIWQFD LETPCQGSMN DPLKHFTEEW SEEDVSVWLR AQGLEDLVGI FRANNIDGKE
LLHLTKESLA GDLKIESLGL RSKVLRSIEE LRAKMDSLSS GIPDEFICPI TRELMKDPVI
ASDGYSYERE AMESWIHKKK RTSPMTNLAL PSLVLTPNRT LKMAINRWLE THEK
