WTF11_SCHPO
ID WTF11_SCHPO Reviewed; 264 AA.
AC Q96WS1;
DT 11-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2002, sequence version 2.
DT 25-MAY-2022, entry version 98.
DE RecName: Full=Wtf element wtf11 {ECO:0000312|PomBase:SPCC1281.08};
GN Name=wtf11 {ECO:0000312|PomBase:SPCC1281.08}; Synonyms=meu24;
GN ORFNames=SPCC1281.08 {ECO:0000312|PomBase:SPCC1281.08};
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 236-264.
RC STRAIN=CD16-1;
RX PubMed=11376151; DOI=10.1093/nar/29.11.2327;
RA Watanabe T., Miyashita K., Saito T.T., Yoneki T., Kakihara Y.,
RA Nabeshima K., Kishi Y.A., Shimoda C., Nojima H.;
RT "Comprehensive isolation of meiosis-specific genes identifies novel
RT proteins and unusual non-coding transcripts in Schizosaccharomyces pombe.";
RL Nucleic Acids Res. 29:2327-2337(2001).
RN [3]
RP LACK OF ALTERNATIVE SPLICING.
RX PubMed=30991417; DOI=10.1093/molbev/msz052;
RA Eickbush M.T., Young J.M., Zanders S.E.;
RT "Killer Meiotic Drive and Dynamic Evolution of the wtf Gene Family.";
RL Mol. Biol. Evol. 36:1201-1214(2019).
RN [4]
RP DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=32032353; DOI=10.1371/journal.pgen.1008350;
RA Bravo Nunez M.A., Sabbarini I.M., Eickbush M.T., Liang Y., Lange J.J.,
RA Kent A.M., Zanders S.E.;
RT "Dramatically diverse Schizosaccharomyces pombe wtf meiotic drivers all
RT display high gamete-killing efficiency.";
RL PLoS Genet. 16:e1008350-e1008350(2020).
CC -!- FUNCTION: May act in meiotic drive. {ECO:0000250|UniProtKB:A0A218N034}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- DEVELOPMENTAL STAGE: Present following meiosis I (at protein level).
CC {ECO:0000269|PubMed:32032353}.
CC -!- DISRUPTION PHENOTYPE: Normal vegetative cell population growth
CC (PubMed:32032353). Simultaneous knockout of wtf15, wtf14 and wtf7
CC results in normal spore viability (PubMed:32032353).
CC {ECO:0000269|PubMed:32032353}.
CC -!- MISCELLANEOUS: Although the gene is capable of encoding two isoforms,
CC RNA sequencing data show no evidence of alternative transcripts.
CC {ECO:0000305|PubMed:30991417}.
CC -!- SIMILARITY: Belongs to the WTF family. {ECO:0000305}.
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DR EMBL; CU329672; CAA22829.1; -; Genomic_DNA.
DR EMBL; AB054308; BAB60875.1; -; mRNA.
DR PIR; T40927; T40927.
DR RefSeq; NP_588172.1; NM_001023161.2.
DR AlphaFoldDB; Q96WS1; -.
DR BioGRID; 275738; 10.
DR STRING; 4896.SPCC1281.08.1; -.
DR PaxDb; Q96WS1; -.
DR EnsemblFungi; SPCC1281.08.1; SPCC1281.08.1:pep; SPCC1281.08.
DR GeneID; 2539167; -.
DR KEGG; spo:SPCC1281.08; -.
DR PomBase; SPCC1281.08; -.
DR VEuPathDB; FungiDB:SPCC1281.08; -.
DR HOGENOM; CLU_092895_0_0_1; -.
DR PhylomeDB; Q96WS1; -.
DR PRO; PR:Q96WS1; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR GO; GO:0005794; C:Golgi apparatus; HDA:PomBase.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0110134; P:meiotic drive; ISM:PomBase.
DR InterPro; IPR004982; WTF.
DR Pfam; PF03303; WTF; 1.
DR PROSITE; PS00014; ER_TARGET; 1.
PE 1: Evidence at protein level;
KW Meiosis; Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..264
FT /note="Wtf element wtf11"
FT /id="PRO_0000193220"
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..165
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..200
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 217..237
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 264 AA; 29937 MW; C3757C87EAB6FD62 CRC64;
MNSNYVPLTS SVDVEEKMES ENGVDLGNDI DLEKGLPLKY NSENESGLPS NSASSYLINP
DPTMDLEAQT FNHNESTTSV GHDNSNSPPK CRKTCSSNKV YSNEVPLLFV FVISISIVCI
FDLVIFGCLQ YNMVSMDDLH VMQRLSWFCA SLALLFILMR YYDFWTKACK DGIKHIFKKW
KNTPLAFLQV LIFNIIGFFV RKGLKDSFGE QWGLKTSLFA HVSFATMSIF IFIFETLKPG
SCSVDWIARI LKAVVYFLED SDEL