ID   WTF13_SCHKA             Reviewed;         360 AA.
AC   A0A482AR57;
DT   07-APR-2021, integrated into UniProtKB/Swiss-Prot.
DT   05-JUN-2019, sequence version 1.
DT   25-MAY-2022, entry version 9.
DE   RecName: Full=Meiotic drive suppressor wtf13 {ECO:0000303|PubMed:32032353};
GN   Name=wtf13 {ECO:0000312|EMBL:QBL54503.1};
OS   Schizosaccharomyces kambucha (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=204045 {ECO:0000312|EMBL:QBL54503.1};
RN   [1] {ECO:0000312|EMBL:QBL54503.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX   PubMed=32032353; DOI=10.1371/journal.pgen.1008350;
RA   Bravo Nunez M.A., Sabbarini I.M., Eickbush M.T., Liang Y., Lange J.J.,
RA   Kent A.M., Zanders S.E.;
RT   "Dramatically diverse Schizosaccharomyces pombe wtf meiotic drivers all
RT   display high gamete-killing efficiency.";
RL   PLoS Genet. 16:e1008350-e1008350(2020).
CC   -!- FUNCTION: Acts as a suppressor component of the dual wtf meiotic drive
CC       system, and can suppress but not confer meiotic drive by compatible
CC       poisons (PubMed:32032353). Wtf meiotic drive systems promote unequal
CC       transmission of alleles from the parental zygote to progeny spores by
CC       encoding a poison and an antidote from the same locus; the poison is
CC       trans-acting and forms toxic aggregates in all spores within an ascus,
CC       wherease the antidote is spore-specific and targets aggregates for
CC       degradation by the vacuole (By similarity). Meiotic drive by wtf
CC       systems therefore lead to poisoning of all progeny that do not inherit
CC       the dual poison/antidote allele, or express a compatible antidote (By
CC       similarity). {ECO:0000250|UniProtKB:A0A218N034,
CC       ECO:0000250|UniProtKB:A0A482ATU4, ECO:0000269|PubMed:32032353}.
CC   -!- SUBUNIT: Homomer (By similarity). Interacts with other proteins that
CC       exhibit high sequence similarity (By similarity).
CC       {ECO:0000250|UniProtKB:A0A218N034, ECO:0000250|UniProtKB:O74420}.
CC   -!- SUBCELLULAR LOCATION: Spore membrane {ECO:0000250|UniProtKB:A0A218N034,
CC       ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Vacuole
CC       membrane {ECO:0000250|UniProtKB:A0A218N034, ECO:0000255}; Multi-pass
CC       membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the WTF family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; MH837439; QBL54503.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A482AR57; -.
DR   GO; GO:0005737; C:cytoplasm; IC:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0110134; P:meiotic drive; EXP:UniProtKB.
DR   InterPro; IPR004982; WTF.
DR   Pfam; PF03303; WTF; 2.
PE   3: Inferred from homology;
KW   Membrane; Transmembrane; Transmembrane helix; Vacuole.
FT   CHAIN           1..360
FT                   /note="Meiotic drive suppressor wtf13"
FT                   /id="PRO_0000452260"
FT   TRANSMEM        90..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        120..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..170
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        186..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        222..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        246..266
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        276..296
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        310..330
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          37..75
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        53..70
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   360 AA;  39535 MW;  421C28A6951CC042 CRC64;
     MKNNYTSLKS SMDEGDELKT GHEFDLEKGI LPEYNSEEEG ALPPYSDISK LANPVPEDSS
     TGPTETTNPN VERRQEFKDS HPNIYSLLRL LISVLAVIVV FFTAWVCVNP LEKSIFGKVA
     FSVTIGITCP IVFIAIFCFF ETWTQAVAQC IKVTVIFLAQ CVKVTVISLA KCVKVIAVGL
     YNSKKDLVVT IWLAWVVICF ILFGCVKDGR LNLNKALICS TSSISAALFF ILLLVCIPIW
     TLKHMLFGLF QVLGVQSCVV IVTKGLMYLL DKHIDATGYE IEASSLFVIG NFLFFYEMER
     PGALKRMPKF IGNGIASFLG GIANAIRGIA NAIGGIANAF RGANDNNDIP LGEMDVESEV