ID   WTF14_SCHKA             Reviewed;         229 AA.
AC   A0A482ASA5;
DT   07-APR-2021, integrated into UniProtKB/Swiss-Prot.
DT   05-JUN-2019, sequence version 1.
DT   25-MAY-2022, entry version 7.
DE   RecName: Full=Wtf element wtf14 {ECO:0000303|PubMed:32032353};
GN   Name=wtf14 {ECO:0000312|EMBL:QBL54504.1};
OS   Schizosaccharomyces kambucha (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=204045 {ECO:0000312|EMBL:QBL54504.1};
RN   [1] {ECO:0000312|EMBL:QBL54504.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND SUBCELLULAR LOCATION.
RX   PubMed=32032353; DOI=10.1371/journal.pgen.1008350;
RA   Bravo Nunez M.A., Sabbarini I.M., Eickbush M.T., Liang Y., Lange J.J.,
RA   Kent A.M., Zanders S.E.;
RT   "Dramatically diverse Schizosaccharomyces pombe wtf meiotic drivers all
RT   display high gamete-killing efficiency.";
RL   PLoS Genet. 16:e1008350-e1008350(2020).
CC   -!- FUNCTION: May act in meiotic drive. {ECO:0000250|UniProtKB:A0A218N034}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000255,
CC       ECO:0000269|PubMed:32032353}; Multi-pass membrane protein
CC       {ECO:0000255}. Note=Localizes to the endoplasmic reticulum in both
CC       vegetative cells and in spores. {ECO:0000269|PubMed:32032353}.
CC   -!- SIMILARITY: Belongs to the WTF family. {ECO:0000305}.
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DR   EMBL; MH837440; QBL54504.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A482ASA5; -.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:1990578; C:perinuclear endoplasmic reticulum membrane; IDA:UniProtKB.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..229
FT                   /note="Wtf element wtf14"
FT                   /id="PRO_0000452261"
FT   TRANSMEM        71..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        151..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        188..208
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..25
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   229 AA;  26099 MW;  627D3684E17E6DB5 CRC64;
     MENNHHLAKD SLDELNPKRG KGEHETQVSQ YTVVEEATIP QSLVKTSRSA DHKVMEASKV
     ADTRTAWSTK IPAVLLPVFV INIALFKYLV FANFSTKDRV LFGLGNGGIN IFSMWLLLAT
     YETWFRSIKE VIVACGAGIR SFPQKRGVNM LYAILKLTFV NAFAIPLLMF FRSHFEQWRL
     GCPLVERVIG VMLNVAYFII EIENPGLFTR VFNKYCDCLF AIRDILNRN