WTF14_SCHPO
ID WTF14_SCHPO Reviewed; 229 AA.
AC O74512;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2012, sequence version 2.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Wtf element wtf14 {ECO:0000312|PomBase:SPCC663.02};
GN Name=wtf14 {ECO:0000312|PomBase:SPCC663.02}; Synonyms=wtf15;
GN ORFNames=SPCC663.02 {ECO:0000312|PomBase:SPCC663.02};
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP REVISION OF GENE MODEL.
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
RN [3]
RP IDENTIFICATION.
RX PubMed=12952871; DOI=10.1101/gr.1191603;
RA Bowen N.J., Jordan I.K., Epstein J.A., Wood V., Levin H.L.;
RT "Retrotransposons and their recognition of pol II promoters: a
RT comprehensive survey of the transposable elements from the complete genome
RT sequence of Schizosaccharomyces pombe.";
RL Genome Res. 13:1984-1997(2003).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [5]
RP LACK OF ALTERNATIVE SPLICING.
RX PubMed=30991417; DOI=10.1093/molbev/msz052;
RA Eickbush M.T., Young J.M., Zanders S.E.;
RT "Killer Meiotic Drive and Dynamic Evolution of the wtf Gene Family.";
RL Mol. Biol. Evol. 36:1201-1214(2019).
RN [6]
RP DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=32032353; DOI=10.1371/journal.pgen.1008350;
RA Bravo Nunez M.A., Sabbarini I.M., Eickbush M.T., Liang Y., Lange J.J.,
RA Kent A.M., Zanders S.E.;
RT "Dramatically diverse Schizosaccharomyces pombe wtf meiotic drivers all
RT display high gamete-killing efficiency.";
RL PLoS Genet. 16:e1008350-e1008350(2020).
CC -!- FUNCTION: May act in meiotic drive. {ECO:0000250|UniProtKB:A0A218N034}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000255,
CC ECO:0000269|PubMed:16823372}; Multi-pass membrane protein {ECO:0000255,
CC ECO:0000269|PubMed:16823372}. Note=Localizes to the endoplasmic
CC reticulum in both vegetative cells and in spores.
CC {ECO:0000250|UniProtKB:A0A482ASA5}.
CC -!- DEVELOPMENTAL STAGE: Expression is constant during meiosis (at protein
CC level). {ECO:0000269|PubMed:32032353}.
CC -!- DISRUPTION PHENOTYPE: Simultaneous knockout of wtf15 results in normal
CC vegetative cell population growth (PubMed:32032353). Simultaneous
CC knockout of wtf15, wtf11 and wtf7 results in normal spore viability
CC (PubMed:32032353). {ECO:0000269|PubMed:32032353}.
CC -!- MISCELLANEOUS: Although the gene is capable of encoding two isoforms,
CC RNA sequencing data show no evidence of alternative transcripts.
CC {ECO:0000305|PubMed:30991417}.
CC -!- SIMILARITY: Belongs to the WTF family. {ECO:0000305}.
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DR EMBL; CU329672; CAA20362.2; -; Genomic_DNA.
DR PIR; T41533; T41533.
DR RefSeq; NP_588264.2; NM_001023254.2.
DR AlphaFoldDB; O74512; -.
DR BioGRID; 275965; 3.
DR STRING; 4896.SPCC663.02.1; -.
DR iPTMnet; O74512; -.
DR MaxQB; O74512; -.
DR PaxDb; O74512; -.
DR PRIDE; O74512; -.
DR EnsemblFungi; SPCC663.02.1; SPCC663.02.1:pep; SPCC663.02.
DR GeneID; 2539400; -.
DR KEGG; spo:SPCC663.02; -.
DR PomBase; SPCC663.02; wtf14.
DR VEuPathDB; FungiDB:SPCC663.02; -.
DR HOGENOM; CLU_1210404_0_0_1; -.
DR PRO; PR:O74512; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:PomBase.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0110134; P:meiotic drive; ISM:PomBase.
PE 1: Evidence at protein level;
KW Endoplasmic reticulum; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..229
FT /note="Wtf element wtf14"
FT /id="PRO_0000193228"
FT TRANSMEM 71..91
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..171
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..208
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..25
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 229 AA; 26109 MW; F3AE3687E0350149 CRC64;
MENNHHLAKD SLDELNPKRG KGEHETQVSQ YTVVEEATIP QSLVKTSRPA DHKVMEASKV
ADTRTAWSTK IPAVLLPVFV INIALFKYLV FANFSTKDRV LFGLGNGGIN IFSMWLLLAT
YETWFRSIKE VIVACGAGIR SFPQKRGVNM LYAILKLTFV NAFAIPLLMF FRSHFEQWRL
GCPLVERVIG VMLNVAYFII EIENPGLFTR VFNKYCDCLF AIRDILNRN