ID   WTF18_SCHKA             Reviewed;         371 AA.
AC   A0A482ARE1;
DT   07-APR-2021, integrated into UniProtKB/Swiss-Prot.
DT   05-JUN-2019, sequence version 1.
DT   25-MAY-2022, entry version 10.
DE   RecName: Full=Meiotic drive suppressor wtf18 {ECO:0000303|PubMed:30475921};
GN   Name=wtf18 {ECO:0000312|EMBL:QBL54507.1};
OS   Schizosaccharomyces kambucha (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=204045 {ECO:0000312|EMBL:QBL54507.1};
RN   [1] {ECO:0000312|EMBL:QBL54507.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=28631612; DOI=10.7554/elife.26033;
RA   Nuckolls N.L., Bravo Nunez M.A., Eickbush M.T., Young J.M., Lange J.J.,
RA   Yu J.S., Smith G.R., Jaspersen S.L., Malik H.S., Zanders S.E.;
RT   "wtf genes are prolific dual poison-antidote meiotic drivers.";
RL   Elife 6:e26033-e26033(2017).
RN   [2] {ECO:0000305}
RP   FUNCTION.
RX   PubMed=30475921; DOI=10.1371/journal.pgen.1007836;
RA   Bravo Nunez M.A., Lange J.J., Zanders S.E.;
RT   "A suppressor of a wtf poison-antidote meiotic driver acts via mimicry of
RT   the driver's antidote.";
RL   PLoS Genet. 14:e1007836-e1007836(2018).
CC   -!- FUNCTION: Acts as a suppressor component of the dual wtf meiotic drive
CC       system, and can suppress but not confer meiotic drive by compatible
CC       poisons (PubMed:30475921). Wtf meiotic drive systems promote unequal
CC       transmission of alleles from the parental zygote to progeny spores by
CC       encoding a poison and an antidote from the same locus; the poison is
CC       trans-acting and forms toxic aggregates in all spores within an ascus,
CC       wherease the antidote is spore-specific and targets aggregates for
CC       degradation by the vacuole (By similarity). Meiotic drive by wtf
CC       systems therefore lead to poisoning of all progeny that do not inherit
CC       the dual poison/antidote allele, or express a compatible antidote (By
CC       similarity). {ECO:0000250|UniProtKB:A0A218N034,
CC       ECO:0000250|UniProtKB:A0A482ATU4, ECO:0000269|PubMed:30475921}.
CC   -!- SUBUNIT: Homomer (By similarity). Interacts with other proteins that
CC       exhibit high sequence similarity (By similarity).
CC       {ECO:0000250|UniProtKB:A0A218N034, ECO:0000250|UniProtKB:O74420}.
CC   -!- SUBCELLULAR LOCATION: Spore membrane {ECO:0000250|UniProtKB:A0A218N034,
CC       ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Vacuole
CC       membrane {ECO:0000250|UniProtKB:A0A218N034, ECO:0000255}; Multi-pass
CC       membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the WTF family. {ECO:0000305}.
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DR   EMBL; MH837444; QBL54507.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A482ARE1; -.
DR   SMR; A0A482ARE1; -.
DR   GO; GO:0005737; C:cytoplasm; IC:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0110134; P:meiotic drive; IGI:UniProtKB.
DR   InterPro; IPR004982; WTF.
DR   Pfam; PF03303; WTF; 2.
PE   3: Inferred from homology;
KW   Membrane; Transmembrane; Transmembrane helix; Vacuole.
FT   CHAIN           1..371
FT                   /note="Meiotic drive suppressor wtf18"
FT                   /id="PRO_0000452263"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        120..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        153..173
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        197..217
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        233..253
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        257..277
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        287..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        321..341
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   371 AA;  40950 MW;  4D90FB4C94EDAE3E CRC64;
     MKNNYTSLKS PLDEEDELKT DHEIDLEKGL LPEYNSEEEG TLPLYSDISK LANPVPEDSS
     TGPTEIANPN VERRQEFKDS HPNIYFLLRL LISVLAVSVV FFTAWVCVNP LEKSIFGKVA
     FSVTIGITCP ILFIATFCFF ETWTQAVAQC IKVTVIFLAQ CVKVTVIFLA QCVKVTAVFL
     AKCVKVIAVG LYNSKKDLVV TIWLAWVVIC FILFGCVKDG RLNLNKALIC STCSISAALF
     FILLLVCIPI WTLKHMLFGL FQVLGVQSCV VIVTKGLMYL FDKHIDATGY EIEASSLFVI
     GNFLFFYEME RPGALKRMPK FIGNGIASFL GGLGNAFGGI GNAIGRIGNA FRGANDNNDI
     PLGEMDVESE V