WTF18_SCHPO
ID WTF18_SCHPO Reviewed; 372 AA.
AC O74495; A0A3G6JAT4;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 07-APR-2021, sequence version 3.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=Meiotic drive suppressor wtf18 {ECO:0000303|PubMed:30475921};
GN Name=wtf18 {ECO:0000312|PomBase:SPCC285.07c}; Synonyms=wtf5;
GN ORFNames=SPCC285.07c {ECO:0000312|PomBase:SPCC285.07c};
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], REVISION OF GENE MODEL, FUNCTION, AND
RP VARIANTS GLU-331 DELINS GLY-GLY-LEU-GLY-ASN-ALA-PHE-GLY-GLY AND
RP 359-ASN--ALA-368 DELINS ASP-ILE-PRO-LEU-GLY-GLU-MET-ASP-VAL.
RC STRAIN=wtf18-2;
RX PubMed=30475921; DOI=10.1371/journal.pgen.1007836;
RA Bravo Nunez M.A., Lange J.J., Zanders S.E.;
RT "A suppressor of a wtf poison-antidote meiotic driver acts via mimicry of
RT the driver's antidote.";
RL PLoS Genet. 14:e1007836-e1007836(2018).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [3]
RP REVISION OF GENE MODEL.
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
CC -!- FUNCTION: Acts as a suppressor component of the dual wtf meiotic drive
CC system, and can suppress but not confer meiotic drive by compatible
CC poisons (PubMed:30475921). Wtf meiotic drive systems promote unequal
CC transmission of alleles from the parental zygote to progeny spores by
CC encoding a poison and an antidote from the same locus; the poison is
CC trans-acting and forms toxic aggregates in all spores within an ascus,
CC wherease the antidote is spore-specific and targets aggregates for
CC degradation by the vacuole (By similarity). Meiotic drive by wtf
CC systems therefore lead to poisoning of all progeny that do not inherit
CC the dual poison/antidote allele, or express a compatible antidote
CC (PubMed:30475921). {ECO:0000250|UniProtKB:A0A218N034,
CC ECO:0000269|PubMed:30475921}.
CC -!- SUBUNIT: Homomer (By similarity). Interacts with other proteins that
CC exhibit high sequence similarity (PubMed:30475921).
CC {ECO:0000250|UniProtKB:A0A218N034, ECO:0000269|PubMed:30475921}.
CC -!- SUBCELLULAR LOCATION: Spore membrane {ECO:0000250|UniProtKB:A0A218N034,
CC ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Vacuole
CC membrane {ECO:0000250|UniProtKB:A0A218N034, ECO:0000255}; Multi-pass
CC membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the WTF family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA20846.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; CU329672; CAA20846.2; ALT_SEQ; Genomic_DNA.
DR EMBL; MH029505; AZA15116.1; -; Genomic_DNA.
DR PIR; T41253; T41253.
DR RefSeq; NP_588335.2; NM_001023326.2.
DR AlphaFoldDB; O74495; -.
DR SMR; O74495; -.
DR BioGRID; 275663; 2.
DR STRING; 4896.SPCC285.07c.1; -.
DR PaxDb; O74495; -.
DR EnsemblFungi; SPCC285.07c.1; SPCC285.07c.1:pep; SPCC285.07c.
DR GeneID; 2539091; -.
DR KEGG; spo:SPCC285.07c; -.
DR PomBase; SPCC285.07c; wtf18.
DR VEuPathDB; FungiDB:SPCC162.04c; -.
DR VEuPathDB; FungiDB:SPCC285.07c; -.
DR HOGENOM; CLU_763247_0_0_1; -.
DR PRO; PR:O74495; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0005737; C:cytoplasm; IDA:PomBase.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0110134; P:meiotic drive; IMP:UniProtKB.
DR InterPro; IPR004982; WTF.
DR Pfam; PF03303; WTF; 2.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix; Vacuole.
FT CHAIN 1..372
FT /note="Meiotic drive suppressor wtf18"
FT /id="PRO_0000193230"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 257..277
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VARIANT 331
FT /note="E -> GGLGNAFG (in strain: wtf18-2; suppresses
FT meiotic drive by wtf13 isoform 2)"
FT /evidence="ECO:0000269|PubMed:30475921"
FT VARIANT 359..368
FT /note="NNIPLEETEA -> DIPLGEMDV (in strain: wtf18-2;
FT suppresses meiotic drive by wtf13 isoform 2)"
FT /evidence="ECO:0000269|PubMed:30475921"
SQ SEQUENCE 372 AA; 41209 MW; 913E41BCE13F95A4 CRC64;
MKNNYTSLKS PLDEEDELKT DHEIDLEKGL LPEYNSEEEG TLPLYSDISK LANPVPEDSS
TGPTEIANPN VERRQEFKDS HPNIYFLLRL LISVLAVSVV FFTAWVCVNP LEKSIFGKVA
FSVTIGITCP ILFIATFCFF ETWTQAVAQC IKVTVIFLAQ CVKVTVIFLA QCVKVTAVFL
AKCVKVIAVG LYNSKKDLVV TIWLAWVVIC FILFGCVKDG RLNLNKALIC STCSISAALF
FILLLVCIPI WTLKHMLFGL FQVLGVQSCV VIVTKGLMYL FDKHIDATGY EIEASSLFVI
GNFLFFYEME CPGALKRMPK FIRNGIASFL EGIGNAFGGI GNAIGRIGNA FRGANDNNNN
IPLEETEAES EV