WTF1_SCHPM
ID WTF1_SCHPM Reviewed; 248 AA.
AC A0A482ATU4;
DT 07-APR-2021, integrated into UniProtKB/Swiss-Prot.
DT 05-JUN-2019, sequence version 1.
DT 25-MAY-2022, entry version 10.
DE RecName: Full=Meiotic drive suppressor wtf1 {ECO:0000303|PubMed:32032353};
GN Name=wtf1 {ECO:0000312|EMBL:QBL54261.1};
OS Schizosaccharomyces pombe (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=4896 {ECO:0000312|EMBL:QBL54261.1};
RN [1] {ECO:0000312|EMBL:QBL54261.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC STRAIN=FY29033 {ECO:0000312|EMBL:QBL54261.1};
RX PubMed=32032353; DOI=10.1371/journal.pgen.1008350;
RA Bravo Nunez M.A., Sabbarini I.M., Eickbush M.T., Liang Y., Lange J.J.,
RA Kent A.M., Zanders S.E.;
RT "Dramatically diverse Schizosaccharomyces pombe wtf meiotic drivers all
RT display high gamete-killing efficiency.";
RL PLoS Genet. 16:e1008350-e1008350(2020).
CC -!- FUNCTION: Acts as a suppressor component of the dual wtf meiotic drive
CC system, and can suppress but not confer meiotic drive by compatible
CC poisons (PubMed:32032353). Wtf meiotic drive systems promote unequal
CC transmission of alleles from the parental zygote to progeny spores by
CC encoding a poison and an antidote from the same locus; the poison is
CC trans-acting and forms toxic aggregates in all spores within an ascus,
CC wherease the antidote is spore-specific and targets aggregates for
CC degradation by the vacuole (By similarity). Meiotic drive by wtf
CC systems therefore lead to poisoning of all progeny that do not inherit
CC the dual poison/antidote allele, or express a compatible antidote
CC (PubMed:32032353). {ECO:0000250|UniProtKB:A0A218N034,
CC ECO:0000269|PubMed:32032353}.
CC -!- SUBUNIT: Homomer (By similarity). Interacts with other proteins that
CC exhibit high sequence similarity (By similarity).
CC {ECO:0000250|UniProtKB:A0A218N034, ECO:0000250|UniProtKB:O74420}.
CC -!- SUBCELLULAR LOCATION: Spore membrane {ECO:0000250|UniProtKB:A0A218N034,
CC ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Vacuole
CC membrane {ECO:0000250|UniProtKB:A0A218N034, ECO:0000255}; Multi-pass
CC membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the WTF family. {ECO:0000305}.
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DR EMBL; MH837193; QBL54261.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A482ATU4; -.
DR VEuPathDB; FungiDB:SPCC1183.10; -.
DR GO; GO:0005737; C:cytoplasm; IC:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0110134; P:meiotic drive; IDA:UniProtKB.
DR InterPro; IPR004982; WTF.
DR Pfam; PF03303; WTF; 1.
PE 3: Inferred from homology;
KW Membrane; Transmembrane; Transmembrane helix; Vacuole.
FT CHAIN 1..248
FT /note="Meiotic drive suppressor wtf1"
FT /id="PRO_0000452252"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..172
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 186..206
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 30..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..68
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 248 AA; 28305 MW; 1065DBFCC7FCF9D8 CRC64;
MKNNYTSLKS SIDKEDELKS VHEIDLEKGL LPEYNSDEES TLPPYSDHAR VSNPPNTHRE
NHSSGTTDNS SPFLIKLLIS FTSIILFNAP AVCYLKYKDA FFKNYGAAEW TLIGFWCASS
LIIFTFSWYF YETWTKAVGK GIKHFLKKWR NIPMAFSEVF LFNILVGSPR VTLRHISGER
WGLKCSLADH IIFAILSILV FIVETVEPGS SKINIMKRLR GDNARDATQH VNEYTAVPLR
EMNPESEA
