ID   WTF26_SCHKA             Reviewed;         321 AA.
AC   A0A218N036;
DT   07-APR-2021, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2017, sequence version 1.
DT   25-MAY-2022, entry version 14.
DE   RecName: Full=Meiotic drive suppressor wtf26 {ECO:0000303|PubMed:28631612};
GN   Name=wtf26 {ECO:0000312|EMBL:ASF62183.1};
OS   Schizosaccharomyces kambucha (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=204045 {ECO:0000312|EMBL:ASF62183.1};
RN   [1] {ECO:0000312|EMBL:ASF62183.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX   PubMed=28631612; DOI=10.7554/elife.26033;
RA   Nuckolls N.L., Bravo Nunez M.A., Eickbush M.T., Young J.M., Lange J.J.,
RA   Yu J.S., Smith G.R., Jaspersen S.L., Malik H.S., Zanders S.E.;
RT   "wtf genes are prolific dual poison-antidote meiotic drivers.";
RL   Elife 6:e26033-e26033(2017).
CC   -!- FUNCTION: Acts as a suppressor component of the dual wtf meiotic drive
CC       system, and can suppress but not confer meiotic drive by compatible
CC       poisons (PubMed:28631612). Wtf meiotic drive systems promote unequal
CC       transmission of alleles from the parental zygote to progeny spores by
CC       encoding a poison and an antidote from the same locus; the poison is
CC       trans-acting and forms toxic aggregates in all spores within an ascus,
CC       wherease the antidote is spore-specific and targets aggregates for
CC       degradation by the vacuole (By similarity). Meiotic drive by wtf
CC       systems therefore lead to poisoning of all progeny that do not inherit
CC       the dual poison/antidote allele, or express a compatible antidote (By
CC       similarity). {ECO:0000250|UniProtKB:A0A218N034,
CC       ECO:0000250|UniProtKB:A0A482ATU4, ECO:0000269|PubMed:28631612}.
CC   -!- SUBUNIT: Homomer (By similarity). Interacts with other proteins that
CC       exhibit high sequence similarity (By similarity).
CC       {ECO:0000250|UniProtKB:A0A218N034, ECO:0000250|UniProtKB:O74420}.
CC   -!- SUBCELLULAR LOCATION: Spore membrane {ECO:0000250|UniProtKB:A0A218N034,
CC       ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Vacuole
CC       membrane {ECO:0000250|UniProtKB:A0A218N034, ECO:0000255}; Multi-pass
CC       membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the WTF family. {ECO:0000305}.
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DR   EMBL; KY652742; ASF62183.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A218N036; -.
DR   SMR; A0A218N036; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0110134; P:meiotic drive; IEA:InterPro.
DR   InterPro; IPR004982; WTF.
DR   Pfam; PF03303; WTF; 1.
PE   3: Inferred from homology;
KW   Membrane; Transmembrane; Transmembrane helix; Vacuole.
FT   CHAIN           1..321
FT                   /note="Meiotic drive suppressor wtf26"
FT                   /id="PRO_0000452267"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        151..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        188..208
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        210..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        243..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          29..68
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        46..68
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   321 AA;  35975 MW;  B97E0B51C52D1E53 CRC64;
     MNNNYTSLKS SIDEEGELKT DHEIDLEKGL LPEYNSEEEG ALPTYSDHAR SSNPPNTHRE
     NHSSGTTDDS SPFLIKLLIS FTPIVLLNAL AVCYLTYKDA FFKDYGAAEW TLFGFWCLVC
     TLALIILTYF YETWTKAVKV TAIGLFNIRR EMMIIIWILW LIICCILFGC VKDGRLNLNK
     ALIYSTCTIS AVLFLIVSSV CIPMWTLWRA LSGMLQVLGI HGIIALLVNG SMSLFGKHFG
     WRGYEIEGFV LFFTGNALFL YEMERPGVLK RMRNTTGNVI GYILEGIGNI GNAIGRIGNA
     FRGANDNNDI PLGEMEVESE V