ID   WTF2_SCHKA              Reviewed;         244 AA.
AC   A0A218N030;
DT   07-APR-2021, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2017, sequence version 1.
DT   25-MAY-2022, entry version 13.
DE   RecName: Full=Meiotic drive suppressor wtf2 {ECO:0000303|PubMed:28631612};
GN   Name=wtf2 {ECO:0000312|EMBL:ASF62181.1};
OS   Schizosaccharomyces kambucha (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=204045 {ECO:0000312|EMBL:ASF62181.1};
RN   [1] {ECO:0000312|EMBL:ASF62181.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX   PubMed=28631612; DOI=10.7554/elife.26033;
RA   Nuckolls N.L., Bravo Nunez M.A., Eickbush M.T., Young J.M., Lange J.J.,
RA   Yu J.S., Smith G.R., Jaspersen S.L., Malik H.S., Zanders S.E.;
RT   "wtf genes are prolific dual poison-antidote meiotic drivers.";
RL   Elife 6:e26033-e26033(2017).
CC   -!- FUNCTION: Acts as a suppressor component of the dual wtf meiotic drive
CC       system, and can suppress but not confer meiotic drive by compatible
CC       poisons (PubMed:28631612). Wtf meiotic drive systems promote unequal
CC       transmission of alleles from the parental zygote to progeny spores by
CC       encoding a poison and an antidote from the same locus; the poison is
CC       trans-acting and forms toxic aggregates in all spores within an ascus,
CC       wherease the antidote is spore-specific and targets aggregates for
CC       degradation by the vacuole (By similarity). Meiotic drive by wtf
CC       systems therefore lead to poisoning of all progeny that do not inherit
CC       the dual poison/antidote allele, or express a compatible antidote (By
CC       similarity). {ECO:0000250|UniProtKB:A0A218N034,
CC       ECO:0000250|UniProtKB:A0A482ATU4, ECO:0000269|PubMed:28631612}.
CC   -!- SUBUNIT: Homomer (By similarity). Interacts with other proteins that
CC       exhibit high sequence similarity (By similarity).
CC       {ECO:0000250|UniProtKB:A0A218N034, ECO:0000250|UniProtKB:O74420}.
CC   -!- SUBCELLULAR LOCATION: Spore membrane {ECO:0000250|UniProtKB:A0A218N034,
CC       ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Vacuole
CC       membrane {ECO:0000250|UniProtKB:A0A218N034, ECO:0000255}; Multi-pass
CC       membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the WTF family. {ECO:0000305}.
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DR   EMBL; KY652740; ASF62181.1; -; Genomic_DNA.
DR   EMBL; MH837432; QBL54497.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A218N030; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0110134; P:meiotic drive; IEA:InterPro.
DR   InterPro; IPR004982; WTF.
DR   Pfam; PF03303; WTF; 1.
PE   3: Inferred from homology;
KW   Membrane; Transmembrane; Transmembrane helix; Vacuole.
FT   CHAIN           1..244
FT                   /note="Meiotic drive suppressor wtf2"
FT                   /id="PRO_0000452253"
FT   TRANSMEM        73..93
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        149..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        183..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..68
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        12..35
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        46..68
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   244 AA;  28179 MW;  741E7FC5AA8B2822 CRC64;
     MKNNYTSLKS SIDEEGELKT DHEIDLEKGP LPEYDSEEES TLPPYSDHAR LSNSPNTHRE
     NNPSRSTDNS SPFLIKLLIS FTPIYVLNVL AICYLKYNDA FFKNYGAAEW TLFGFWCLVC
     TLALIFLTYF YETWTKAVGK GIKHFLKKWE NMPMAFSEVF LFNILVGSPR MNLRYIFGDR
     WGLKWSLAEH ITFVVLSILV FIAETVKPGS IRVNLIRKMG YEAKQQVNEY TAVPLREMNP
     ESEA