WTF5_SCHKA
ID WTF5_SCHKA Reviewed; 269 AA.
AC A0A218N033;
DT 07-APR-2021, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2017, sequence version 1.
DT 25-MAY-2022, entry version 13.
DE RecName: Full=Meiotic drive suppressor wtf5 {ECO:0000303|PubMed:28631612};
GN Name=wtf5 {ECO:0000312|EMBL:ASF62182.1};
OS Schizosaccharomyces kambucha (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=204045 {ECO:0000312|EMBL:ASF62182.1};
RN [1] {ECO:0000312|EMBL:ASF62182.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX PubMed=28631612; DOI=10.7554/elife.26033;
RA Nuckolls N.L., Bravo Nunez M.A., Eickbush M.T., Young J.M., Lange J.J.,
RA Yu J.S., Smith G.R., Jaspersen S.L., Malik H.S., Zanders S.E.;
RT "wtf genes are prolific dual poison-antidote meiotic drivers.";
RL Elife 6:e26033-e26033(2017).
CC -!- FUNCTION: Acts as a suppressor component of the dual wtf meiotic drive
CC system, and can suppress but not confer meiotic drive by compatible
CC poisons (PubMed:28631612). Wtf meiotic drive systems promote unequal
CC transmission of alleles from the parental zygote to progeny spores by
CC encoding a poison and an antidote from the same locus; the poison is
CC trans-acting and forms toxic aggregates in all spores within an ascus,
CC wherease the antidote is spore-specific and targets aggregates for
CC degradation by the vacuole (By similarity). Meiotic drive by wtf
CC systems therefore lead to poisoning of all progeny that do not inherit
CC the dual poison/antidote allele, or express a compatible antidote (By
CC similarity). {ECO:0000250|UniProtKB:A0A218N034,
CC ECO:0000250|UniProtKB:A0A482ATU4, ECO:0000269|PubMed:28631612}.
CC -!- SUBUNIT: Homomer (By similarity). Interacts with other proteins that
CC exhibit high sequence similarity (By similarity).
CC {ECO:0000250|UniProtKB:A0A218N034, ECO:0000250|UniProtKB:O74420}.
CC -!- SUBCELLULAR LOCATION: Spore membrane {ECO:0000250|UniProtKB:A0A218N034,
CC ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Vacuole
CC membrane {ECO:0000250|UniProtKB:A0A218N034, ECO:0000255}; Multi-pass
CC membrane protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the WTF family. {ECO:0000305}.
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DR EMBL; KY652741; ASF62182.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A218N033; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0110134; P:meiotic drive; IEA:InterPro.
DR InterPro; IPR004982; WTF.
DR Pfam; PF03303; WTF; 1.
PE 3: Inferred from homology;
KW Membrane; Transmembrane; Transmembrane helix; Vacuole.
FT CHAIN 1..269
FT /note="Meiotic drive suppressor wtf5"
FT /id="PRO_0000452255"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 174..194
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 216..236
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 46..67
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 269 AA; 30749 MW; 19887305FF1C1DE5 CRC64;
MKNNHTSLKS PLDEEDELKT DHEIDLEKGP LPEYDSEEES TLPPYSDHAL VNNPPNTHRE
NHSYRTTDNS SPLLIKLLIS FTSIILFNAP AVCYLKYKDA FFKNYGAAEW TLFGFWCLVC
TLALIFLTYF YETWTKAVKV TVISLAKCVK VTAIFLAQCV KACGKGIKHF LKKWENMPMA
FSEVFLFNIL VGSPRMNLRY IFGDRWGLKC SLADHIIFVV LSILVFIAET VKPGSIRVNL
IRKMGYEAKQ QVNEYTAVPL REMNPESEA