WTF7_SCHPO
ID WTF7_SCHPO Reviewed; 215 AA.
AC Q7Z9I5;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 07-APR-2021, sequence version 4.
DT 25-MAY-2022, entry version 77.
DE RecName: Full=Wtf element wtf7 {ECO:0000312|PomBase:SPCC736.05};
GN Name=wtf7 {ECO:0000312|PomBase:SPCC736.05};
GN ORFNames=SPCC736.05 {ECO:0000312|PomBase:SPCC736.05};
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP REVISION OF GENE MODEL.
RX PubMed=21511999; DOI=10.1126/science.1203357;
RA Rhind N., Chen Z., Yassour M., Thompson D.A., Haas B.J., Habib N.,
RA Wapinski I., Roy S., Lin M.F., Heiman D.I., Young S.K., Furuya K., Guo Y.,
RA Pidoux A., Chen H.M., Robbertse B., Goldberg J.M., Aoki K., Bayne E.H.,
RA Berlin A.M., Desjardins C.A., Dobbs E., Dukaj L., Fan L., FitzGerald M.G.,
RA French C., Gujja S., Hansen K., Keifenheim D., Levin J.Z., Mosher R.A.,
RA Mueller C.A., Pfiffner J., Priest M., Russ C., Smialowska A., Swoboda P.,
RA Sykes S.M., Vaughn M., Vengrova S., Yoder R., Zeng Q., Allshire R.,
RA Baulcombe D., Birren B.W., Brown W., Ekwall K., Kellis M., Leatherwood J.,
RA Levin H., Margalit H., Martienssen R., Nieduszynski C.A., Spatafora J.W.,
RA Friedman N., Dalgaard J.Z., Baumann P., Niki H., Regev A., Nusbaum C.;
RT "Comparative functional genomics of the fission yeasts.";
RL Science 332:930-936(2011).
RN [3]
RP REVISION OF GENE MODEL, AND LACK OF ALTERNATIVE SPLICING.
RX PubMed=30991417; DOI=10.1093/molbev/msz052;
RA Eickbush M.T., Young J.M., Zanders S.E.;
RT "Killer Meiotic Drive and Dynamic Evolution of the wtf Gene Family.";
RL Mol. Biol. Evol. 36:1201-1214(2019).
RN [4]
RP IDENTIFICATION.
RX PubMed=12952871; DOI=10.1101/gr.1191603;
RA Bowen N.J., Jordan I.K., Epstein J.A., Wood V., Levin H.L.;
RT "Retrotransposons and their recognition of pol II promoters: a
RT comprehensive survey of the transposable elements from the complete genome
RT sequence of Schizosaccharomyces pombe.";
RL Genome Res. 13:1984-1997(2003).
RN [5]
RP DISRUPTION PHENOTYPE.
RX PubMed=32032353; DOI=10.1371/journal.pgen.1008350;
RA Bravo Nunez M.A., Sabbarini I.M., Eickbush M.T., Liang Y., Lange J.J.,
RA Kent A.M., Zanders S.E.;
RT "Dramatically diverse Schizosaccharomyces pombe wtf meiotic drivers all
RT display high gamete-killing efficiency.";
RL PLoS Genet. 16:e1008350-e1008350(2020).
CC -!- FUNCTION: May act in meiotic drive. {ECO:0000250|UniProtKB:A0A218N034}.
CC -!- SUBCELLULAR LOCATION: Spore membrane {ECO:0000250|UniProtKB:A0A482APM8,
CC ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
CC -!- DISRUPTION PHENOTYPE: Normal vegetative cell population growth
CC (PubMed:32032353). Simultaneous knockout of wtf15, wtf14 and wtf11
CC results in normal spore viability (PubMed:32032353).
CC {ECO:0000269|PubMed:32032353}.
CC -!- MISCELLANEOUS: Although the gene is capable of encoding two isoforms,
CC RNA sequencing data show no evidence of alternative transcripts.
CC {ECO:0000305|PubMed:30991417}.
CC -!- SIMILARITY: Belongs to the WTF family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA19269.3; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; CU329672; CAA19269.3; ALT_SEQ; Genomic_DNA.
DR PIR; T41562; T41562.
DR RefSeq; NP_587776.3; NM_001022769.3.
DR AlphaFoldDB; Q7Z9I5; -.
DR STRING; 4896.SPCC736.05.1; -.
DR PaxDb; Q7Z9I5; -.
DR EnsemblFungi; SPCC736.05.1; SPCC736.05.1:pep; SPCC736.05.
DR GeneID; 2539521; -.
DR KEGG; spo:SPCC736.05; -.
DR PomBase; SPCC736.05; wtf7.
DR VEuPathDB; FungiDB:SPCC736.05; -.
DR HOGENOM; CLU_1267539_0_0_1; -.
DR PRO; PR:Q7Z9I5; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0005737; C:cytoplasm; IDA:PomBase.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0110134; P:meiotic drive; ISM:PomBase.
DR InterPro; IPR004982; WTF.
DR Pfam; PF03303; WTF; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..215
FT /note="Wtf element wtf7"
FT /id="PRO_0000193223"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 149..169
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..209
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 215 AA; 24639 MW; CFFDCCDD55D803B6 CRC64;
MSGSYAPIED SADELSVHSG NDNEIDLEKG LLPKCNTGNG GTTPCSEPPH YDSDAVVEMD
MYENNIYMRT FKLRPFAKSG VTNSSNVVFQ MKTYENNRHM QTFRLRPFAK NGVTNGVKLA
QSLFLLLPFN FIFFACLFFR KASFTDFSLM GWILFGIWCL TCFLSSFILY AYHESWTKFA
RERSQEFSLI LFGLLFPGIV TMVVFYALYM RSMYG
