WTM2_YEAST
ID WTM2_YEAST Reviewed; 467 AA.
AC Q12206; D6W2T3;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 176.
DE RecName: Full=Transcriptional modulator WTM2;
GN Name=WTM2; OrderedLocusNames=YOR229W; ORFNames=YOR50-19;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 96604 / S288c / FY1679;
RX PubMed=8840505;
RX DOI=10.1002/(sici)1097-0061(199607)12:9<877::aid-yea969>3.0.co;2-s;
RA Galisson F., Dujon B.;
RT "Sequence and analysis of a 33 kb fragment from the right arm of chromosome
RT XV of the yeast Saccharomyces cerevisiae.";
RL Yeast 12:877-885(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169874;
RA Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J.,
RA Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A.,
RA Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B.,
RA Dang V.-D., de Haan M., Delius H., Durand P., Fairhead C., Feldmann H.,
RA Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E.,
RA Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U.,
RA Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B.,
RA Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A.,
RA Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C.,
RA Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G.,
RA Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B.,
RA Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B.,
RA Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F.,
RA Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E.,
RA Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I.,
RA Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H.,
RA Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.";
RL Nature 387:98-102(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19779198; DOI=10.1126/science.1172867;
RA Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.;
RT "Global analysis of Cdk1 substrate phosphorylation sites provides insights
RT into evolution.";
RL Science 325:1682-1686(2009).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- FUNCTION: Transcriptional modulator with roles in meiotic regulation
CC and silencing.
CC -!- INTERACTION:
CC Q12206; Q12363: WTM1; NbExp=3; IntAct=EBI-20571, EBI-20563;
CC -!- MISCELLANEOUS: Present with 3750 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
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DR EMBL; X92441; CAA63192.1; -; Genomic_DNA.
DR EMBL; Z75137; CAA99449.1; -; Genomic_DNA.
DR EMBL; BK006948; DAA10999.1; -; Genomic_DNA.
DR PIR; S60956; S60956.
DR RefSeq; NP_014872.1; NM_001183648.1.
DR AlphaFoldDB; Q12206; -.
DR BioGRID; 34622; 66.
DR DIP; DIP-1534N; -.
DR IntAct; Q12206; 24.
DR MINT; Q12206; -.
DR STRING; 4932.YOR229W; -.
DR iPTMnet; Q12206; -.
DR MaxQB; Q12206; -.
DR PaxDb; Q12206; -.
DR PRIDE; Q12206; -.
DR EnsemblFungi; YOR229W_mRNA; YOR229W; YOR229W.
DR GeneID; 854404; -.
DR KEGG; sce:YOR229W; -.
DR SGD; S000005755; WTM2.
DR VEuPathDB; FungiDB:YOR229W; -.
DR eggNOG; ENOG502QSEV; Eukaryota.
DR GeneTree; ENSGT00940000176348; -.
DR HOGENOM; CLU_036523_0_0_1; -.
DR InParanoid; Q12206; -.
DR OMA; LTHRQNG; -.
DR BioCyc; YEAST:G3O-33727-MON; -.
DR Reactome; R-SCE-3214815; HDACs deacetylate histones.
DR Reactome; R-SCE-3214847; HATs acetylate histones.
DR Reactome; R-SCE-3214858; RMTs methylate histone arginines.
DR PRO; PR:Q12206; -.
DR Proteomes; UP000002311; Chromosome XV.
DR RNAct; Q12206; protein.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IDA:SGD.
DR GO; GO:0005634; C:nucleus; IDA:SGD.
DR GO; GO:0033698; C:Rpd3L complex; IBA:GO_Central.
DR GO; GO:0070210; C:Rpd3L-Expanded complex; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IDA:SGD.
DR GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR GO; GO:0003714; F:transcription corepressor activity; IDA:SGD.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; IMP:SGD.
DR GO; GO:0006338; P:chromatin remodeling; IBA:GO_Central.
DR GO; GO:0016575; P:histone deacetylation; IBA:GO_Central.
DR GO; GO:0061186; P:negative regulation of silent mating-type cassette heterochromatin assembly; IGI:SGD.
DR GO; GO:0010674; P:negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle; IGI:SGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:SGD.
DR GO; GO:0031503; P:protein-containing complex localization; IMP:SGD.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Meiosis; Reference proteome; Repeat; Transcription;
KW Transcription regulation; WD repeat.
FT CHAIN 1..467
FT /note="Transcriptional modulator WTM2"
FT /id="PRO_0000051464"
FT REPEAT 244..282
FT /note="WD 1"
FT REPEAT 287..327
FT /note="WD 2"
FT REPEAT 349..389
FT /note="WD 3"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 84..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 467 AA; 51951 MW; 4A8F5F879B88AA94 CRC64;
MAKSKSSQGA SGARRKPAPS LYQHISSFKP QFSTRVDDVL HFSKTLTWRS EIIPDKSKGT
LTTSLLYSQG SDIYEIDTTL PLKTFYDDDD DDDNDDDDEE GNGKTKSAAT PNPEYGDAFQ
DVEGKPLRPK WIYQGETVAK MQYLESSDDS TAIAMSKNGS LAWFRDEIKV PVHIVQEMMG
PATRYSSIHS LTRPGSLAVS DFDVSTNMDT VVKSQSNGYE EDSILKIIDN SDRPGDILRT
VHVPGTNVAH SVRFFNNHLF ASCSDDNILR FWDTRTADKP LWTLSEPKNG RLTSFDSSQV
TENLFVTGFS TGVIKLWDAR AVQLATTDLT HRQNGEEPIQ NEIAKLFHSG GDSVVDILFS
QTSATEFVTV GGTGNVYHWD MEYSFSRNDD DNEDEVRVAA PEELQGQCLK FFHTGGTRRS
SNQFGKRNTV ALHPVINDFV GTVDSDSLVT AYKPFLASDF IGRGYDD
