WTPB_PYRAB
ID WTPB_PYRAB Reviewed; 248 AA.
AC Q9V2C1; G8ZFY8;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 102.
DE RecName: Full=Molybdate/tungstate transport system permease protein WtpB;
GN Name=wtpB; OrderedLocusNames=PYRAB01530; ORFNames=PAB0102;
OS Pyrococcus abyssi (strain GE5 / Orsay).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Pyrococcus.
OX NCBI_TaxID=272844;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=GE5 / Orsay;
RX PubMed=12622808; DOI=10.1046/j.1365-2958.2003.03381.x;
RA Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O.,
RA Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J.,
RA Weissenbach J., Zivanovic Y., Forterre P.;
RT "An integrated analysis of the genome of the hyperthermophilic archaeon
RT Pyrococcus abyssi.";
RL Mol. Microbiol. 47:1495-1512(2003).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=GE5 / Orsay;
RX PubMed=22057919; DOI=10.1007/s00284-011-0035-x;
RA Gao J., Wang J.;
RT "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and
RT Pyrococcus furiosus DSM 3638.";
RL Curr. Microbiol. 64:118-129(2012).
CC -!- FUNCTION: Part of the ABC transporter complex WtpABC involved in
CC molybdate/tungstate import. Probably responsible for the translocation
CC of the substrate across the membrane (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (WtpC),
CC two transmembrane proteins (WtpB) and a solute-binding protein (WtpA).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ248283; CAB49077.1; -; Genomic_DNA.
DR EMBL; HE613800; CCE69529.1; -; Genomic_DNA.
DR PIR; F75203; F75203.
DR RefSeq; WP_010867277.1; NC_000868.1.
DR AlphaFoldDB; Q9V2C1; -.
DR SMR; Q9V2C1; -.
DR STRING; 272844.PAB0102; -.
DR EnsemblBacteria; CAB49077; CAB49077; PAB0102.
DR GeneID; 1495040; -.
DR KEGG; pab:PAB0102; -.
DR PATRIC; fig|272844.11.peg.166; -.
DR eggNOG; arCOG00164; Archaea.
DR HOGENOM; CLU_016047_14_1_2; -.
DR OMA; NEYNFVA; -.
DR OrthoDB; 97465at2157; -.
DR PhylomeDB; Q9V2C1; -.
DR Proteomes; UP000000810; Chromosome.
DR Proteomes; UP000009139; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR CDD; cd06261; TM_PBP2; 1.
DR Gene3D; 1.10.3720.10; -; 1.
DR InterPro; IPR000515; MetI-like.
DR InterPro; IPR035906; MetI-like_sf.
DR Pfam; PF00528; BPD_transp_1; 1.
DR SUPFAM; SSF161098; SSF161098; 1.
DR PROSITE; PS50928; ABC_TM1; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Molybdenum; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..248
FT /note="Molybdate/tungstate transport system permease
FT protein WtpB"
FT /id="PRO_0000338497"
FT TOPO_DOM 1..9
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 31..56
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 78..91
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 113..115
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..136
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 137..164
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 186..223
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 224..244
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 245..248
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 53..239
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
SQ SEQUENCE 248 AA; 26904 MW; 12AC15A6D20F4B8A CRC64;
MGGRDYTLYL FAALGSFLIV YIALPIIVIF TKQALDFRML VKTIHDPLVI EALRNSLLTA
TATALISLLF GVPLGYVLAR KDFRGKSLVQ AIIDVPIVIP HSVVGIMLLV TFSNAILDSY
KGIIAAMLFV SAPFAINSAR DGFLAVDEKL EHVARTLGAS KLRTFFSISL PIALPSIASG
AIMAWARGIS EVGAILIVAY YPKTAQVLVM EYFNNYGLRA SRPISVILMG ISLGIFVVLR
WLIGKAKS
