WTPB_PYRFU
ID WTPB_PYRFU Reviewed; 249 AA.
AC Q8U4K4;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 2.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=Molybdate/tungstate transport system permease protein WtpB {ECO:0000305};
GN Name=wtpB {ECO:0000303|PubMed:16952940}; OrderedLocusNames=PF0081;
OS Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Pyrococcus.
OX NCBI_TaxID=186497;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1;
RX PubMed=10430560; DOI=10.1093/genetics/152.4.1299;
RA Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M.,
RA DiRuggiero J., Robb F.T.;
RT "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P.
RT horikoshii inferred from complete genomic sequences.";
RL Genetics 152:1299-1305(1999).
RN [2]
RP PROBABLE FUNCTION, AND GENE NAME.
RX PubMed=16952940; DOI=10.1128/jb.00548-06;
RA Bevers L.E., Hagedoorn P.-L., Krijger G.C., Hagen W.R.;
RT "Tungsten transport protein A (WtpA) in Pyrococcus furiosus: the first
RT member of a new class of tungstate and molybdate transporters.";
RL J. Bacteriol. 188:6498-6505(2006).
CC -!- FUNCTION: Part of the ABC transporter complex WtpABC involved in
CC molybdate/tungstate import. Probably responsible for the translocation
CC of the substrate across the membrane. {ECO:0000305|PubMed:16952940}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (WtpC),
CC two transmembrane proteins (WtpB) and a solute-binding protein (WtpA).
CC {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC permease family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL80205.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE009950; AAL80205.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_014835477.1; NZ_CP023154.1.
DR AlphaFoldDB; Q8U4K4; -.
DR SMR; Q8U4K4; -.
DR STRING; 186497.PF0081; -.
DR TCDB; 3.A.1.6.5; the atp-binding cassette (abc) superfamily.
DR EnsemblBacteria; AAL80205; AAL80205; PF0081.
DR GeneID; 41711869; -.
DR KEGG; pfu:PF0081; -.
DR PATRIC; fig|186497.12.peg.85; -.
DR eggNOG; arCOG00164; Archaea.
DR HOGENOM; CLU_016047_14_1_2; -.
DR OrthoDB; 97465at2157; -.
DR Proteomes; UP000001013; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR CDD; cd06261; TM_PBP2; 1.
DR Gene3D; 1.10.3720.10; -; 1.
DR InterPro; IPR000515; MetI-like.
DR InterPro; IPR035906; MetI-like_sf.
DR Pfam; PF00528; BPD_transp_1; 1.
DR SUPFAM; SSF161098; SSF161098; 1.
DR PROSITE; PS50928; ABC_TM1; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Molybdenum; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..249
FT /note="Molybdate/tungstate transport system permease
FT protein WtpB"
FT /id="PRO_0000338498"
FT TOPO_DOM 1..10
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 11..31
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 32..56
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..77
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 78..96
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..117
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 118
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 140..179
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..200
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 201..223
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 224..244
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TOPO_DOM 245..249
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 53..239
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
SQ SEQUENCE 249 AA; 27336 MW; DCB5883C212BE656 CRC64;
MDRRDYLAYA FAGLGAFLVA FIGLPLFMIF IKQAYDLEAL QRTLVDPLVI ESIRNSLFTA
TVSTLLGILF GVPLGYVLAR KEFKGKNFVQ ALIDTPIVIP HSVVGIMLLV TFSDAILDNY
KGIVAVMLFV SSPFIVNSAR DGFLSVDEKL EYVARTLGAS GLRTFFSVTL PNAIHSIASG
AIMAWARAIS EVGAILIVAY YPKTAQVLIM EYFNNYGLRA SRPIAVILVT ISLAVFIFLR
WLVGRGRNA
