ID   WTPC_METJA              Reviewed;         297 AA.
AC   Q58762;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 129.
DE   RecName: Full=Molybdate/tungstate import ATP-binding protein WtpC;
DE            EC=7.3.2.6 {ECO:0000250|UniProtKB:Q8U4K3};
GN   Name=wtpC; OrderedLocusNames=MJ1367;
OS   Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM
OS   10045 / NBRC 100440) (Methanococcus jannaschii).
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC   Methanocaldococcaceae; Methanocaldococcus.
OX   NCBI_TaxID=243232;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440;
RX   PubMed=8688087; DOI=10.1126/science.273.5278.1058;
RA   Bult C.J., White O., Olsen G.J., Zhou L., Fleischmann R.D., Sutton G.G.,
RA   Blake J.A., FitzGerald L.M., Clayton R.A., Gocayne J.D., Kerlavage A.R.,
RA   Dougherty B.A., Tomb J.-F., Adams M.D., Reich C.I., Overbeek R.,
RA   Kirkness E.F., Weinstock K.G., Merrick J.M., Glodek A., Scott J.L.,
RA   Geoghagen N.S.M., Weidman J.F., Fuhrmann J.L., Nguyen D., Utterback T.R.,
RA   Kelley J.M., Peterson J.D., Sadow P.W., Hanna M.C., Cotton M.D.,
RA   Roberts K.M., Hurst M.A., Kaine B.P., Borodovsky M., Klenk H.-P.,
RA   Fraser C.M., Smith H.O., Woese C.R., Venter J.C.;
RT   "Complete genome sequence of the methanogenic archaeon, Methanococcus
RT   jannaschii.";
RL   Science 273:1058-1073(1996).
CC   -!- FUNCTION: Part of the ABC transporter complex WtpABC involved in
CC       molybdate/tungstate import. Responsible for energy coupling to the
CC       transport system. {ECO:0000250|UniProtKB:Q8U4K3}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O + tungstate(in) = ADP + H(+) + phosphate +
CC         tungstate(out); Xref=Rhea:RHEA:35027, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:46502, ChEBI:CHEBI:456216; EC=7.3.2.6;
CC         Evidence={ECO:0000250|UniProtKB:Q8U4K3};
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (WtpC),
CC       two transmembrane proteins (WtpB) and a solute-binding protein (WtpA).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily.
CC       Sulfate/tungstate importer (TC 3.A.1.6) family. {ECO:0000305}.
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DR   EMBL; L77117; AAB99375.1; -; Genomic_DNA.
DR   PIR; F64470; F64470.
DR   RefSeq; WP_010870884.1; NC_000909.1.
DR   AlphaFoldDB; Q58762; -.
DR   SMR; Q58762; -.
DR   STRING; 243232.MJ_1367; -.
DR   TCDB; 3.A.1.6.9; the atp-binding cassette (abc) superfamily.
DR   EnsemblBacteria; AAB99375; AAB99375; MJ_1367.
DR   GeneID; 1452270; -.
DR   KEGG; mja:MJ_1367; -.
DR   eggNOG; arCOG00175; Archaea.
DR   HOGENOM; CLU_000604_1_1_2; -.
DR   InParanoid; Q58762; -.
DR   OMA; HFIILGP; -.
DR   OrthoDB; 88924at2157; -.
DR   PhylomeDB; Q58762; -.
DR   Proteomes; UP000000805; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:1901238; F:ABC-type tungstate transporter activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell membrane; Membrane; Molybdenum; Nucleotide-binding;
KW   Reference proteome; Translocase; Transport.
FT   CHAIN           1..297
FT                   /note="Molybdate/tungstate import ATP-binding protein WtpC"
FT                   /id="PRO_0000093225"
FT   DOMAIN          2..226
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         32..39
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   297 AA;  33266 MW;  710DB22733EEB122 CRC64;
     MLKVNNLSKI WKDFKLKNVS FEIDREYCVI LGPSGAGKSV LIKCIAGILK PDSGRIILNG
     EDITNLPPEK RNVGYVPQNY ALFPNKNVYK NIAYGLIIKK VNKLEIDRKV KEIAEFLNIS
     HLLNRDVKTL SGGEQQRVAL ARALILNPSI LLLDEPTSAV DIKIKESIIS ELKKIKHIPV
     LHITHDLAEA RTLGEKVGIF MNGELIAFGD KSILKKPKNK KVAEFLGFNI IDDKAIAPED
     VIIKDGNGGE VVNIIDYGKY KKVFVKYNGY IIKAFTERDL NIGDNVGLEF REQTKLT