ID   WTPC_PYRAB              Reviewed;         344 AA.
AC   Q9V2C0; G8ZFY9;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 131.
DE   RecName: Full=Molybdate/tungstate import ATP-binding protein WtpC;
DE            EC=7.3.2.6 {ECO:0000250|UniProtKB:Q8U4K3};
GN   Name=wtpC; OrderedLocusNames=PYRAB01540; ORFNames=PAB0103;
OS   Pyrococcus abyssi (strain GE5 / Orsay).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=272844;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GE5 / Orsay;
RX   PubMed=12622808; DOI=10.1046/j.1365-2958.2003.03381.x;
RA   Cohen G.N., Barbe V., Flament D., Galperin M., Heilig R., Lecompte O.,
RA   Poch O., Prieur D., Querellou J., Ripp R., Thierry J.-C., Van der Oost J.,
RA   Weissenbach J., Zivanovic Y., Forterre P.;
RT   "An integrated analysis of the genome of the hyperthermophilic archaeon
RT   Pyrococcus abyssi.";
RL   Mol. Microbiol. 47:1495-1512(2003).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=GE5 / Orsay;
RX   PubMed=22057919; DOI=10.1007/s00284-011-0035-x;
RA   Gao J., Wang J.;
RT   "Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and
RT   Pyrococcus furiosus DSM 3638.";
RL   Curr. Microbiol. 64:118-129(2012).
CC   -!- FUNCTION: Part of the ABC transporter complex WtpABC involved in
CC       molybdate/tungstate import. Responsible for energy coupling to the
CC       transport system. {ECO:0000250|UniProtKB:Q8U4K3}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O + tungstate(in) = ADP + H(+) + phosphate +
CC         tungstate(out); Xref=Rhea:RHEA:35027, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:46502, ChEBI:CHEBI:456216; EC=7.3.2.6;
CC         Evidence={ECO:0000250|UniProtKB:Q8U4K3};
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (WtpC),
CC       two transmembrane proteins (WtpB) and a solute-binding protein (WtpA).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily.
CC       Sulfate/tungstate importer (TC 3.A.1.6) family. {ECO:0000305}.
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DR   EMBL; AJ248283; CAB49078.1; -; Genomic_DNA.
DR   EMBL; HE613800; CCE69530.1; -; Genomic_DNA.
DR   PIR; G75203; G75203.
DR   RefSeq; WP_010867278.1; NC_000868.1.
DR   AlphaFoldDB; Q9V2C0; -.
DR   SMR; Q9V2C0; -.
DR   STRING; 272844.PAB0103; -.
DR   EnsemblBacteria; CAB49078; CAB49078; PAB0103.
DR   GeneID; 1495041; -.
DR   KEGG; pab:PAB0103; -.
DR   PATRIC; fig|272844.11.peg.167; -.
DR   eggNOG; arCOG00175; Archaea.
DR   HOGENOM; CLU_000604_1_1_2; -.
DR   OMA; HFIILGP; -.
DR   OrthoDB; 88924at2157; -.
DR   PhylomeDB; Q9V2C0; -.
DR   Proteomes; UP000000810; Chromosome.
DR   Proteomes; UP000009139; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:1901238; F:ABC-type tungstate transporter activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0015689; P:molybdate ion transport; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR008995; Mo/tungstate-bd_C_term_dom.
DR   InterPro; IPR004606; Mop_domain.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005116; Transp-assoc_OB_typ1.
DR   Pfam; PF00005; ABC_tran; 1.
DR   Pfam; PF03459; TOBE; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF50331; SSF50331; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00638; Mop; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR   PROSITE; PS51866; MOP; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell membrane; Membrane; Molybdenum; Nucleotide-binding;
KW   Translocase; Transport.
FT   CHAIN           1..344
FT                   /note="Molybdate/tungstate import ATP-binding protein WtpC"
FT                   /id="PRO_0000338502"
FT   DOMAIN          2..231
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   DOMAIN          280..344
FT                   /note="Mop"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01213"
FT   BINDING         33..40
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   344 AA;  38497 MW;  A55002B5FE66BC78 CRC64;
     MLRVESVSKD YKEFKLRDIS FDVKKEEHFI ILGPSGAGKT VLLEIIAGII EPDEGRIILN
     GVDVTSYPPE KRNLAYIPQD YALFPHMTVY DNIAFGLKLR RISRQEIDRK VKEISKVLGI
     EHLLHRKPRT LSGGEKQRVA IARALVIEPE LLLLDEPFAN LDVQTKSRFM TEMKVWRKEL
     GFTSLHVTHS FEEAISLGDR VGVMLRGRLV QVGDVKEVFS NPVDEGVARF LGFENIIEGV
     AKGNILEANG VKITLPISVE GKVRIGVRPE DIILSTEPVK TSARNEFRAE VIGIEELGPL
     VRVNLKIGGI TLKAFITRSS LIELGISEGR EVYVSFKTSA IKVF