ID   WTPC_PYRFU              Reviewed;         344 AA.
AC   Q8U4K3;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=Molybdate/tungstate import ATP-binding protein WtpC {ECO:0000305};
DE            EC=7.3.2.6 {ECO:0000305|PubMed:16952940};
GN   Name=wtpC {ECO:0000303|PubMed:16952940}; OrderedLocusNames=PF0082;
OS   Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=186497;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1;
RX   PubMed=10430560; DOI=10.1093/genetics/152.4.1299;
RA   Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M.,
RA   DiRuggiero J., Robb F.T.;
RT   "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P.
RT   horikoshii inferred from complete genomic sequences.";
RL   Genetics 152:1299-1305(1999).
RN   [2]
RP   PROBABLE FUNCTION, AND GENE NAME.
RX   PubMed=16952940; DOI=10.1128/jb.00548-06;
RA   Bevers L.E., Hagedoorn P.-L., Krijger G.C., Hagen W.R.;
RT   "Tungsten transport protein A (WtpA) in Pyrococcus furiosus: the first
RT   member of a new class of tungstate and molybdate transporters.";
RL   J. Bacteriol. 188:6498-6505(2006).
CC   -!- FUNCTION: Part of the ABC transporter complex WtpABC involved in
CC       molybdate/tungstate import. Probably responsible for energy coupling to
CC       the transport system. {ECO:0000305|PubMed:16952940}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O + tungstate(in) = ADP + H(+) + phosphate +
CC         tungstate(out); Xref=Rhea:RHEA:35027, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:46502, ChEBI:CHEBI:456216; EC=7.3.2.6;
CC         Evidence={ECO:0000305|PubMed:16952940};
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (WtpC),
CC       two transmembrane proteins (WtpB) and a solute-binding protein (WtpA).
CC       {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily.
CC       Sulfate/tungstate importer (TC 3.A.1.6) family. {ECO:0000305}.
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DR   EMBL; AE009950; AAL80206.1; -; Genomic_DNA.
DR   RefSeq; WP_011011194.1; NZ_CP023154.1.
DR   AlphaFoldDB; Q8U4K3; -.
DR   SMR; Q8U4K3; -.
DR   STRING; 186497.PF0082; -.
DR   TCDB; 3.A.1.6.5; the atp-binding cassette (abc) superfamily.
DR   EnsemblBacteria; AAL80206; AAL80206; PF0082.
DR   GeneID; 41711870; -.
DR   KEGG; pfu:PF0082; -.
DR   PATRIC; fig|186497.12.peg.86; -.
DR   eggNOG; arCOG00175; Archaea.
DR   HOGENOM; CLU_000604_1_1_2; -.
DR   OMA; HFIILGP; -.
DR   OrthoDB; 88924at2157; -.
DR   PhylomeDB; Q8U4K3; -.
DR   Proteomes; UP000001013; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:1901238; F:ABC-type tungstate transporter activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0015689; P:molybdate ion transport; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR008995; Mo/tungstate-bd_C_term_dom.
DR   InterPro; IPR004606; Mop_domain.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005116; Transp-assoc_OB_typ1.
DR   Pfam; PF00005; ABC_tran; 1.
DR   Pfam; PF03459; TOBE; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF50331; SSF50331; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00638; Mop; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR   PROSITE; PS51866; MOP; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell membrane; Membrane; Molybdenum; Nucleotide-binding;
KW   Reference proteome; Translocase; Transport.
FT   CHAIN           1..344
FT                   /note="Molybdate/tungstate import ATP-binding protein WtpC"
FT                   /id="PRO_0000338503"
FT   DOMAIN          2..231
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   DOMAIN          280..344
FT                   /note="Mop"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01213"
FT   BINDING         33..40
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   344 AA;  38436 MW;  E2578B2722E9A635 CRC64;
     MLEVQGISKK WKDFHLKDIS FSVMDGEYFI VLGPSGAGKT VLLEIIAGII PPDGGKVLLD
     GKDITLLPPE KRGIAYVPQN YALFPNMSVF DNIAFGLKVR RVPRSEIEKR VLEISEVLGI
     RHLLHRKPRT LSGGEQQRVA VARALVIEPE IILLDEPFAN LDVQIRSRLI NEMKRWRREL
     GFTAIHVTHS FEEALALGDR VGIMLNGKLV QVGEIREVFS RPNSEEVAKF LGFENIIEGI
     ADGRVLHVGK LRIELPLEAK GRVRIGIRPE DILISTERIK TSARNVFKAK VEAIEDVGPL
     VKLTLNVCDI TLRAFITRSS LVELGIEEGK EVYASFKASA IHVF