ID   WTPC_PYRHO              Reviewed;         345 AA.
AC   O57896;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 144.
DE   RecName: Full=Molybdate/tungstate import ATP-binding protein WtpC;
DE            EC=7.3.2.6 {ECO:0000250|UniProtKB:Q8U4K3};
GN   Name=wtpC; OrderedLocusNames=PH0157;
OS   Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC
OS   100139 / OT-3).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=70601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3;
RX   PubMed=9679194; DOI=10.1093/dnares/5.2.55;
RA   Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S.,
RA   Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K.,
RA   Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T., Tanaka T.,
RA   Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Yoshizawa T.,
RA   Nakamura Y., Robb F.T., Horikoshi K., Masuchi Y., Shizuya H., Kikuchi H.;
RT   "Complete sequence and gene organization of the genome of a hyper-
RT   thermophilic archaebacterium, Pyrococcus horikoshii OT3.";
RL   DNA Res. 5:55-76(1998).
CC   -!- FUNCTION: Part of the ABC transporter complex WtpABC involved in
CC       molybdate/tungstate import. Responsible for energy coupling to the
CC       transport system. {ECO:0000250|UniProtKB:Q8U4K3}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O + tungstate(in) = ADP + H(+) + phosphate +
CC         tungstate(out); Xref=Rhea:RHEA:35027, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:46502, ChEBI:CHEBI:456216; EC=7.3.2.6;
CC         Evidence={ECO:0000250|UniProtKB:Q8U4K3};
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (WtpC),
CC       two transmembrane proteins (WtpB) and a solute-binding protein (WtpA).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily.
CC       Sulfate/tungstate importer (TC 3.A.1.6) family. {ECO:0000305}.
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DR   EMBL; BA000001; BAA29226.1; -; Genomic_DNA.
DR   PIR; C71237; C71237.
DR   RefSeq; WP_010884268.1; NC_000961.1.
DR   AlphaFoldDB; O57896; -.
DR   SMR; O57896; -.
DR   STRING; 70601.3256543; -.
DR   EnsemblBacteria; BAA29226; BAA29226; BAA29226.
DR   GeneID; 1444050; -.
DR   KEGG; pho:PH0157; -.
DR   eggNOG; arCOG00175; Archaea.
DR   OMA; HFIILGP; -.
DR   OrthoDB; 88924at2157; -.
DR   Proteomes; UP000000752; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:1901238; F:ABC-type tungstate transporter activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0015689; P:molybdate ion transport; IEA:InterPro.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR008995; Mo/tungstate-bd_C_term_dom.
DR   InterPro; IPR004606; Mop_domain.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005116; Transp-assoc_OB_typ1.
DR   Pfam; PF00005; ABC_tran; 1.
DR   Pfam; PF03459; TOBE; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF50331; SSF50331; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00638; Mop; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR   PROSITE; PS51866; MOP; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell membrane; Membrane; Molybdenum; Nucleotide-binding;
KW   Translocase; Transport.
FT   CHAIN           1..345
FT                   /note="Molybdate/tungstate import ATP-binding protein WtpC"
FT                   /id="PRO_0000338504"
FT   DOMAIN          2..231
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   DOMAIN          280..345
FT                   /note="Mop"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01213"
FT   BINDING         33..40
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   345 AA;  38928 MW;  98BE76AD8E74C1EF CRC64;
     MLKVESISKD YREFKLREIS FDVREGEHFI ILGPSGSGKT VLLEIIAGII SPDRGRILLR
     GEDITGLPPE KRNFSYIPQN YALFPHMTVF DNIAFGLKLR KIPRKEVARK VREVAESLGI
     DHLLHRKPRT LSGGEQQRVA IARALVVKPE LLLMDEPFAN LDVQTKSKLI REMKRWRKEF
     GFTAIHVTHS FEEALSLGDR VGIMLRGRLV QVGDVRDVFS KPKSEEVARF LGFENIIEGV
     ANGRILKVGD LRIELPREVW GKVRVGIRPE DITIFMEGVK TSARNVFKAR VEGIEDLGAL
     VKLTLNLGGI ILRAFITRSS LIELGIREGE EVYASFKASA IHVFP