ID   WTPC_THEKO              Reviewed;         330 AA.
AC   Q5JEB0;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Molybdate/tungstate import ATP-binding protein WtpC;
DE            EC=7.3.2.6 {ECO:0000250|UniProtKB:Q8U4K3};
GN   Name=wtpC; OrderedLocusNames=TK0021;
OS   Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
OS   (Pyrococcus kodakaraensis (strain KOD1)).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Thermococcus.
OX   NCBI_TaxID=69014;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-918 / JCM 12380 / KOD1;
RX   PubMed=15710748; DOI=10.1101/gr.3003105;
RA   Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.;
RT   "Complete genome sequence of the hyperthermophilic archaeon Thermococcus
RT   kodakaraensis KOD1 and comparison with Pyrococcus genomes.";
RL   Genome Res. 15:352-363(2005).
CC   -!- FUNCTION: Part of the ABC transporter complex WtpABC involved in
CC       molybdate/tungstate import. Responsible for energy coupling to the
CC       transport system. {ECO:0000250|UniProtKB:Q8U4K3}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O + tungstate(in) = ADP + H(+) + phosphate +
CC         tungstate(out); Xref=Rhea:RHEA:35027, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:46502, ChEBI:CHEBI:456216; EC=7.3.2.6;
CC         Evidence={ECO:0000250|UniProtKB:Q8U4K3};
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (WtpC),
CC       two transmembrane proteins (WtpB) and a solute-binding protein (WtpA).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane
CC       protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily.
CC       Sulfate/tungstate importer (TC 3.A.1.6) family. {ECO:0000305}.
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DR   EMBL; AP006878; BAD84210.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q5JEB0; -.
DR   SMR; Q5JEB0; -.
DR   STRING; 69014.TK0021; -.
DR   EnsemblBacteria; BAD84210; BAD84210; TK0021.
DR   KEGG; tko:TK0021; -.
DR   PATRIC; fig|69014.16.peg.21; -.
DR   eggNOG; arCOG00175; Archaea.
DR   HOGENOM; CLU_000604_1_1_2; -.
DR   InParanoid; Q5JEB0; -.
DR   OMA; HFIILGP; -.
DR   PhylomeDB; Q5JEB0; -.
DR   Proteomes; UP000000536; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:1901238; F:ABC-type tungstate transporter activity; IEA:UniProtKB-EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR008995; Mo/tungstate-bd_C_term_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF50331; SSF50331; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell membrane; Membrane; Molybdenum; Nucleotide-binding;
KW   Reference proteome; Translocase; Transport.
FT   CHAIN           1..330
FT                   /note="Molybdate/tungstate import ATP-binding protein WtpC"
FT                   /id="PRO_0000338505"
FT   DOMAIN          3..232
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         34..41
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   330 AA;  36445 MW;  99FD07D0AE8CA71D CRC64;
     MVLMVEGISK DYREFHLRDV TFSVEKGEHF IILGPSGAGK TVLLEVIAGI IEPDSGRIFL
     NGEDITDLPP EKRGLAYIPQ NYALFPNMSV FDNIAFGLKV RKVPKAEIGR KVRELSEVLG
     ISHLLKRKPK TLSGGEMQRV AIARALAVEP ELLLLDEPFA NLDVQTRGRL INEMKRWRKE
     LGFTALHVTH SFEEAVSLGD RVGVMLNGRL VQVGPVREVF SRPASEEVAK FLGFENIVEG
     LAEGRILRAN GLVIELPIEA SGRIRVGIRP EDIVLSDEPL KSSMRNTFQA EVQADVEELG
     ELGPRTRKAK GRWSGAFSIR YPLFGAGAGA