WTR10_ARATH
ID WTR10_ARATH Reviewed; 356 AA.
AC F4HVM3; Q9C9F2;
DT 06-MAR-2013, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 54.
DE RecName: Full=WAT1-related protein At1g68170;
GN OrderedLocusNames=At1g68170; ORFNames=T22E19.23;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC superfamily. Plant drug/metabolite exporter (P-DME) (TC 2.A.7.4)
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG52606.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC016447; AAG52606.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE34759.1; -; Genomic_DNA.
DR PIR; A96705; A96705.
DR RefSeq; NP_176984.2; NM_105487.3.
DR AlphaFoldDB; F4HVM3; -.
DR BioGRID; 28366; 2.
DR IntAct; F4HVM3; 2.
DR STRING; 3702.AT1G68170.1; -.
DR PaxDb; F4HVM3; -.
DR PRIDE; F4HVM3; -.
DR EnsemblPlants; AT1G68170.1; AT1G68170.1; AT1G68170.
DR GeneID; 843145; -.
DR Gramene; AT1G68170.1; AT1G68170.1; AT1G68170.
DR KEGG; ath:AT1G68170; -.
DR Araport; AT1G68170; -.
DR TAIR; locus:2199327; AT1G68170.
DR eggNOG; ENOG502QR4Y; Eukaryota.
DR HOGENOM; CLU_025359_1_0_1; -.
DR InParanoid; F4HVM3; -.
DR PRO; PR:F4HVM3; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; F4HVM3; baseline and differential.
DR Genevisible; F4HVM3; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR000620; EamA_dom.
DR InterPro; IPR030184; WAT1-related.
DR PANTHER; PTHR31218; PTHR31218; 1.
DR Pfam; PF00892; EamA; 2.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT CHAIN 1..356
FT /note="WAT1-related protein At1g68170"
FT /id="PRO_0000421318"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 176..196
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..230
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..265
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 298..318
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 14..142
FT /note="EamA 1"
FT DOMAIN 191..317
FT /note="EamA 2"
SQ SEQUENCE 356 AA; 38797 MW; 9875348EC7043653 CRC64;
MKDITAMVVV QIATAGLNIF FKLAMEDGMN PSVLVAYRLL FATLFMIPIC FIFQRKKRPE
FTCRLMLLAL LSGLLGVVIP SILTITGLAL TSATFTSAAG VLTPLVTFIF AALLRMESVR
LGSSVGLAKV FGTLFGVGGA LVFIFYRGIE IRLWSTHVNL VNQPRDSSRD ATTHHISILG
ALLVFGGNIS ISLWFLLQVK ISKQFGGPYW NATLMNMMGG VVAMLVALCW EHDLDEWRLG
WNIRLLTIAY AAILISGMVV AVNAWCIESR GPLFVSVFSP VGLVIVALVG SFLLDETLHL
GSIIGTVIIV GALYIVLWAK NKEMKSMLTT SDHNETNKTS KDITVNNLPT LSTNVP
