WTR11_ARATH
ID WTR11_ARATH Reviewed; 375 AA.
AC F4I5D5; O04519; O04520;
DT 06-MAR-2013, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 56.
DE RecName: Full=WAT1-related protein At1g70260;
GN OrderedLocusNames=At1g70260; ORFNames=F20P5.1, F20P5.2;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14993207; DOI=10.1101/gr.1515604;
RA Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M.,
RA Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M.,
RA Weissenbach J., Salanoubat M.;
RT "Whole genome sequence comparisons and 'full-length' cDNA sequences: a
RT combined approach to evaluate and improve Arabidopsis genome annotation.";
RL Genome Res. 14:406-413(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC superfamily. Plant drug/metabolite exporter (P-DME) (TC 2.A.7.4)
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB61090.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAB61091.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BX815890; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AC002062; AAB61090.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC002062; AAB61091.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE35038.1; -; Genomic_DNA.
DR EMBL; BX815890; -; NOT_ANNOTATED_CDS; mRNA.
DR PIR; F96725; F96725.
DR PIR; G96725; G96725.
DR RefSeq; NP_177183.2; NM_105694.3.
DR AlphaFoldDB; F4I5D5; -.
DR STRING; 3702.AT1G70260.1; -.
DR TCDB; 2.A.7.4.7; the drug/metabolite transporter (dmt) superfamily.
DR PaxDb; F4I5D5; -.
DR PRIDE; F4I5D5; -.
DR EnsemblPlants; AT1G70260.1; AT1G70260.1; AT1G70260.
DR GeneID; 843362; -.
DR Gramene; AT1G70260.1; AT1G70260.1; AT1G70260.
DR KEGG; ath:AT1G70260; -.
DR Araport; AT1G70260; -.
DR TAIR; locus:2020688; AT1G70260.
DR eggNOG; ENOG502QW2M; Eukaryota.
DR HOGENOM; CLU_025359_0_1_1; -.
DR InParanoid; F4I5D5; -.
DR OMA; MEGCTIG; -.
DR OrthoDB; 705112at2759; -.
DR PRO; PR:F4I5D5; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; F4I5D5; baseline and differential.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:TAIR.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1900425; P:negative regulation of defense response to bacterium; IMP:TAIR.
DR GO; GO:1902289; P:negative regulation of defense response to oomycetes; IMP:TAIR.
DR GO; GO:1900150; P:regulation of defense response to fungus; IMP:TAIR.
DR InterPro; IPR000620; EamA_dom.
DR InterPro; IPR030184; WAT1-related.
DR PANTHER; PTHR31218; PTHR31218; 1.
DR Pfam; PF00892; EamA; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..375
FT /note="WAT1-related protein At1g70260"
FT /id="PRO_0000421319"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 225..245
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 259..278
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 289..309
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 312..332
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 25..134
FT /note="EamA"
FT REGION 337..356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..356
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 110
FT /note="A -> S (in Ref. 3; BX815890)"
FT /evidence="ECO:0000305"
FT CONFLICT 116
FT /note="P -> R (in Ref. 3; BX815890)"
FT /evidence="ECO:0000305"
FT CONFLICT 208
FT /note="F -> L (in Ref. 3; BX815890)"
FT /evidence="ECO:0000305"
FT CONFLICT 229
FT /note="Y -> N (in Ref. 3; BX815890)"
FT /evidence="ECO:0000305"
FT CONFLICT 301
FT /note="T -> K (in Ref. 3; BX815890)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 375 AA; 42167 MW; C86768192D38A3B2 CRC64;
MEVKVRRDEL VPFVAMAIME ACTIALTIMA KTALTGGMSP FVFVVYTNAF GSILLLPFSF
LFHRNERTEQ SIFSWPLLVR VFFLGFTGIF MFQNLAFVGL RFSSPIVVCA MGLQIPSFSF
LLSIILGRSK LDWRNTSTRA KLMGTIVSLS GAFVEELYKG PFIRPASSAS PNRFLKSVPK
LLVYYNLPDN WFLGCIFLAV AVFSVSLFNV VQTGTVKKYP HVMKVASFYS IVGTIQCLLF
SLFMERDLSA WKIQPNFDLY LIIATGTFGS VIRTSVHVKC TQMKGPYYVP LFKPFGIFWA
TLFGTSFFVN SLHYGSVLGA AIAGVGYFTV SWGQLKESEE KQSSNEERKS IKTIHHRDED
EYKVPLLINQ EESPV
