WTR13_ARATH
ID WTR13_ARATH Reviewed; 380 AA.
AC Q9ZUS1; Q8LE45;
DT 06-MAR-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 116.
DE RecName: Full=WAT1-related protein At2g37460;
GN OrderedLocusNames=At2g37460; ORFNames=F3G5.25;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC superfamily. Plant drug/metabolite exporter (P-DME) (TC 2.A.7.4)
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM62850.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC005896; AAC98072.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC09403.1; -; Genomic_DNA.
DR EMBL; AY035102; AAK59607.1; -; mRNA.
DR EMBL; AY044320; AAK73261.1; -; mRNA.
DR EMBL; AY063035; AAL34209.1; -; mRNA.
DR EMBL; AY085629; AAM62850.1; ALT_INIT; mRNA.
DR PIR; A84793; A84793.
DR RefSeq; NP_181282.1; NM_129301.6.
DR AlphaFoldDB; Q9ZUS1; -.
DR iPTMnet; Q9ZUS1; -.
DR MetOSite; Q9ZUS1; -.
DR PaxDb; Q9ZUS1; -.
DR PRIDE; Q9ZUS1; -.
DR ProteomicsDB; 243086; -.
DR EnsemblPlants; AT2G37460.1; AT2G37460.1; AT2G37460.
DR GeneID; 818323; -.
DR Gramene; AT2G37460.1; AT2G37460.1; AT2G37460.
DR KEGG; ath:AT2G37460; -.
DR Araport; AT2G37460; -.
DR TAIR; locus:2049847; AT2G37460.
DR eggNOG; ENOG502QUF7; Eukaryota.
DR HOGENOM; CLU_025359_1_1_1; -.
DR InParanoid; Q9ZUS1; -.
DR OMA; THETKID; -.
DR OrthoDB; 932852at2759; -.
DR PhylomeDB; Q9ZUS1; -.
DR PRO; PR:Q9ZUS1; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9ZUS1; baseline and differential.
DR Genevisible; Q9ZUS1; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR000620; EamA_dom.
DR InterPro; IPR030184; WAT1-related.
DR PANTHER; PTHR31218; PTHR31218; 1.
DR Pfam; PF00892; EamA; 2.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT CHAIN 1..380
FT /note="WAT1-related protein At2g37460"
FT /id="PRO_0000421321"
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 45..65
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 71..91
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..207
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 216..236
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 254..274
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 282..302
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 306..326
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 27..134
FT /note="EamA 1"
FT DOMAIN 196..325
FT /note="EamA 2"
FT CONFLICT 343
FT /note="E -> K (in Ref. 4; AAM62850)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 380 AA; 41531 MW; 65962C9087DE2541 CRC64;
MEEVKKRDCM EKARPFISMV VLQVGLAGMD ILSKAVLNKG MSNYVLVVYR HAVATIVMAP
FAFYFDKKVR PKMTLMIFFK ISLLGLLEPV IDQNLYYLGM KYTTATFATA MYNVLPAITF
VLAYIFGLER VKLRCIRSTG KVVGTLATVG GAMIMTLVKG PVLDLFWTKG VSAHNTAGTD
IHSAIKGAVL VTIGCFSYAC FMILQAITLR TYPAELSLTA WICLMGTIEG TAVALVMEKG
NPSAWAIGWD TKLLTATYSG IVCSALAYYV GGVVMKTRGP VFVTAFSPLC MIIVAIMSTI
IFAEQMYLGR VLGAVVICAG LYLVIWGKGK DYKYNSTLQL DDESAQPKLE LSGNGKDNVD
HEVITISKQG EQRRTAVETV
