WTR14_ARATH
ID WTR14_ARATH Reviewed; 374 AA.
AC O80638;
DT 06-MAR-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=WAT1-related protein At2g39510;
GN OrderedLocusNames=At2g39510; ORFNames=F12L6.17;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC superfamily. Plant drug/metabolite exporter (P-DME) (TC 2.A.7.4)
CC family. {ECO:0000305}.
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DR EMBL; AC004218; AAC27842.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC09688.1; -; Genomic_DNA.
DR EMBL; BT006205; AAP12854.1; -; mRNA.
DR EMBL; AK227747; BAE99731.1; -; mRNA.
DR PIR; T00561; T00561.
DR RefSeq; NP_181483.1; NM_129509.4.
DR AlphaFoldDB; O80638; -.
DR BioGRID; 3874; 21.
DR IntAct; O80638; 21.
DR STRING; 3702.AT2G39510.1; -.
DR TCDB; 2.A.7.4.5; the drug/metabolite transporter (dmt) superfamily.
DR iPTMnet; O80638; -.
DR PaxDb; O80638; -.
DR PRIDE; O80638; -.
DR ProteomicsDB; 242401; -.
DR EnsemblPlants; AT2G39510.1; AT2G39510.1; AT2G39510.
DR GeneID; 818536; -.
DR Gramene; AT2G39510.1; AT2G39510.1; AT2G39510.
DR KEGG; ath:AT2G39510; -.
DR Araport; AT2G39510; -.
DR TAIR; locus:2039792; AT2G39510.
DR eggNOG; ENOG502QUF7; Eukaryota.
DR HOGENOM; CLU_025359_1_1_1; -.
DR InParanoid; O80638; -.
DR OMA; GIGYYVQ; -.
DR OrthoDB; 683356at2759; -.
DR PhylomeDB; O80638; -.
DR PRO; PR:O80638; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; O80638; baseline and differential.
DR Genevisible; O80638; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:TAIR.
DR GO; GO:0015186; F:L-glutamine transmembrane transporter activity; IDA:TAIR.
DR GO; GO:0098712; P:L-glutamate import across plasma membrane; IDA:TAIR.
DR GO; GO:0048316; P:seed development; IMP:TAIR.
DR InterPro; IPR000620; EamA_dom.
DR InterPro; IPR030184; WAT1-related.
DR PANTHER; PTHR31218; PTHR31218; 1.
DR Pfam; PF00892; EamA; 2.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT CHAIN 1..374
FT /note="WAT1-related protein At2g39510"
FT /id="PRO_0000421322"
FT TRANSMEM 9..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 64..84
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 182..202
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..232
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 249..269
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 284..304
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 306..326
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 19..147
FT /note="EamA 1"
FT DOMAIN 191..320
FT /note="EamA 2"
FT REGION 350..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 355..374
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 374 AA; 40674 MW; EA0E976785C3A6BC CRC64;
MALKTWKPFI TVVSLQFGYA GLSIIAKFAL NQGMSPHVLA SYRHIVATIF IAPFAYFLDR
KIRPKMTLSI FFKILLLGLL EPTIDQNLYY TGMKYTSATF TAAMTNVLPA FAFIMAWIFR
LEKVNVKKIH SQAKILGTIV TVGGAMLMTV VKGPLIPLPW ANPHDIHQDS SNTGVKQDLT
KGASLIAIGC ICWAGFINLQ AITLKSYPVE LSLTAYICFL GSIESTIVAL FIERGNPSAW
AIHLDSKLLA AVYGGVICSG IGYYVQGVIM KTRGPVFVTA FNPLSMVIVA ILGSIILAEV
MFLGRILGAI VIVLGLYSVL WGKSKDEPSS SFSDMDKELP LSTPQIVLPS KANAKMDTND
ASVVISRPNT NESV
