WTR17_ARATH
ID WTR17_ARATH Reviewed; 383 AA.
AC Q9LV20; F4J7L0; F4J7L1;
DT 06-MAR-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=WAT1-related protein At3g18200;
GN OrderedLocusNames=At3g18200; ORFNames=MRC8.20;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence
RT features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC
RT clones.";
RL DNA Res. 7:217-221(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 14-383.
RC STRAIN=cv. Columbia;
RX PubMed=14993207; DOI=10.1101/gr.1515604;
RA Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M.,
RA Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M.,
RA Weissenbach J., Salanoubat M.;
RT "Whole genome sequence comparisons and 'full-length' cDNA sequences: a
RT combined approach to evaluate and improve Arabidopsis genome annotation.";
RL Genome Res. 14:406-413(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=Additional isoforms seem to exist.;
CC Name=1;
CC IsoId=Q9LV20-1; Sequence=Displayed;
CC -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC superfamily. Plant drug/metabolite exporter (P-DME) (TC 2.A.7.4)
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BX824196; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AB020749; BAB02033.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE76063.2; -; Genomic_DNA.
DR EMBL; BX824196; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; NP_188448.2; NM_112703.4. [Q9LV20-1]
DR AlphaFoldDB; Q9LV20; -.
DR SMR; Q9LV20; -.
DR STRING; 3702.AT3G18200.1; -.
DR PaxDb; Q9LV20; -.
DR PRIDE; Q9LV20; -.
DR ProteomicsDB; 243094; -. [Q9LV20-1]
DR EnsemblPlants; AT3G18200.2; AT3G18200.2; AT3G18200. [Q9LV20-1]
DR GeneID; 821347; -.
DR Gramene; AT3G18200.2; AT3G18200.2; AT3G18200. [Q9LV20-1]
DR KEGG; ath:AT3G18200; -.
DR Araport; AT3G18200; -.
DR TAIR; locus:2092702; AT3G18200.
DR eggNOG; ENOG502QSV3; Eukaryota.
DR HOGENOM; CLU_025359_1_2_1; -.
DR OMA; FNNWKIQ; -.
DR OrthoDB; 937588at2759; -.
DR PhylomeDB; Q9LV20; -.
DR PRO; PR:Q9LV20; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LV20; baseline and differential.
DR Genevisible; Q9LV20; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR000620; EamA_dom.
DR InterPro; IPR030184; WAT1-related.
DR PANTHER; PTHR31218; PTHR31218; 1.
DR Pfam; PF00892; EamA; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..383
FT /note="WAT1-related protein At3g18200"
FT /id="PRO_0000421325"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 91..111
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..146
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 158..178
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..224
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 300..320
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 325..345
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 44..173
FT /note="EamA 1"
FT DOMAIN 216..344
FT /note="EamA 2"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 339
FT /note="G -> A (in Ref. 3; BX824196)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 383 AA; 42846 MW; E014B3128B3FB517 CRC64;
MCYQTSKKKR RSRKRRAQEE KEKMGKGVVS EKVKLVVALI TLQFCFAGFH IVSRVALNIG
VSKVVYPVYR NLLALLLIGP FAYFFEKKER PPLTISLLAQ FFFLALIGIT ANQGFYLLGL
YYATPTFASA MQNSVPAITF IMACALRLEH IDLVRKHGVA KVLGTLVSIG GATVITLYRG
FPIFDQGLNM QKEEVVGSDN SHSLTLGWLY LMGHCLSWAG WMVLQAPVLK QYPAKLTLTS
FTCFFGLIQF LVIALFVETD LNNWIIVSWE ELFTILYAGI IASGLVVYLQ TWCIYKSGPV
FVAVFQPLQT LLVAAMAFLI LGDQLYSGGI VGAVFIMLGL YLVLWGKNEE RKLALEESQQ
DPESLTKHLL EAQHKKSNSE SEV
