WTR18_ARATH
ID WTR18_ARATH Reviewed; 367 AA.
AC Q94JU2; Q8L9I2; Q9LRT0;
DT 06-MAR-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=WAT1-related protein At3g28050;
GN OrderedLocusNames=At3g28050; ORFNames=MMG15.6;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence
RT features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC
RT clones.";
RL DNA Res. 7:217-221(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC superfamily. Plant drug/metabolite exporter (P-DME) (TC 2.A.7.4)
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB01127.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB028616; BAB01127.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE77395.1; -; Genomic_DNA.
DR EMBL; AF372936; AAK50076.1; -; mRNA.
DR EMBL; AY133520; AAM91350.1; -; mRNA.
DR EMBL; AY088415; AAM65952.1; -; mRNA.
DR RefSeq; NP_566831.1; NM_113723.4.
DR AlphaFoldDB; Q94JU2; -.
DR BioGRID; 7759; 9.
DR IntAct; Q94JU2; 9.
DR STRING; 3702.AT3G28050.1; -.
DR iPTMnet; Q94JU2; -.
DR PaxDb; Q94JU2; -.
DR PRIDE; Q94JU2; -.
DR ProteomicsDB; 243043; -.
DR EnsemblPlants; AT3G28050.1; AT3G28050.1; AT3G28050.
DR GeneID; 822429; -.
DR Gramene; AT3G28050.1; AT3G28050.1; AT3G28050.
DR KEGG; ath:AT3G28050; -.
DR Araport; AT3G28050; -.
DR TAIR; locus:2091363; AT3G28050.
DR eggNOG; ENOG502QRQK; Eukaryota.
DR HOGENOM; CLU_025359_0_1_1; -.
DR InParanoid; Q94JU2; -.
DR OMA; TIGFYTV; -.
DR OrthoDB; 927776at2759; -.
DR PhylomeDB; Q94JU2; -.
DR PRO; PR:Q94JU2; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q94JU2; baseline and differential.
DR Genevisible; Q94JU2; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR000620; EamA_dom.
DR InterPro; IPR030184; WAT1-related.
DR PANTHER; PTHR31218; PTHR31218; 1.
DR Pfam; PF00892; EamA; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT CHAIN 1..367
FT /note="WAT1-related protein At3g28050"
FT /id="PRO_0000421326"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 246..266
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 276..296
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..321
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 25..153
FT /note="EamA 1"
FT DOMAIN 195..319
FT /note="EamA 2"
FT REGION 338..367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 126
FT /note="E -> D (in Ref. 4; AAM65952)"
FT /evidence="ECO:0000305"
FT CONFLICT 214
FT /note="V -> I (in Ref. 4; AAM65952)"
FT /evidence="ECO:0000305"
FT CONFLICT 222
FT /note="S -> I (in Ref. 4; AAM65952)"
FT /evidence="ECO:0000305"
FT CONFLICT 354
FT /note="K -> E (in Ref. 4; AAM65952)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 367 AA; 40056 MW; 6416AD039FB07B45 CRC64;
MARKYFQREV LPVTALVIME CANVGLNTLF KAATLKGMSF HVFIVYSYGL AALLLLPSLF
CSFRSRTLPP MNFSILYKIV LLGIIGCCSN IMGYTGINYS SPTLASAISN LTPAFTFLLA
VVFRMESVSF KRTSSVAKML GTVVSIGGAF IVTLYNGPVV IAKSPPSVSL RSQSTNPNWI
LGAGFLAVEY FCVPLWYIVQ TQIMREYPAE FTVVCFYSIG VSFWTALVTL FTEGNDLGAW
KIKPNIALVS IVCSGLFGSC INNTIHTWAL RIKGPLFVAM FKPLSIAIAV AMGVIFLRDS
LYIGSLIGAT VITIGFYTVM WGKAKEVALV EDDNKANHEE ANEADLDSPS GSQKAPLLES
YKNDEHV
