WTR34_ARATH
ID WTR34_ARATH Reviewed; 359 AA.
AC F4JMI7; O23505;
DT 06-MAR-2013, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 59.
DE RecName: Full=WAT1-related protein At4g16620;
GN OrderedLocusNames=At4g16620; ORFNames=dl4335c, FCAALL.421;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9461215; DOI=10.1038/35140;
RA Bevan M., Bancroft I., Bent E., Love K., Goodman H.M., Dean C.,
RA Bergkamp R., Dirkse W., van Staveren M., Stiekema W., Drost L., Ridley P.,
RA Hudson S.-A., Patel K., Murphy G., Piffanelli P., Wedler H., Wedler E.,
RA Wambutt R., Weitzenegger T., Pohl T., Terryn N., Gielen J., Villarroel R.,
RA De Clercq R., van Montagu M., Lecharny A., Aubourg S., Gy I., Kreis M.,
RA Lao N., Kavanagh T., Hempel S., Kotter P., Entian K.-D., Rieger M.,
RA Schaefer M., Funk B., Mueller-Auer S., Silvey M., James R., Monfort A.,
RA Pons A., Puigdomenech P., Douka A., Voukelatou E., Milioni D.,
RA Hatzopoulos P., Piravandi E., Obermaier B., Hilbert H., Duesterhoeft A.,
RA Moores T., Jones J.D.G., Eneva T., Palme K., Benes V., Rechmann S.,
RA Ansorge W., Cooke R., Berger C., Delseny M., Voet M., Volckaert G.,
RA Mewes H.-W., Klosterman S., Schueller C., Chalwatzis N.;
RT "Analysis of 1.9 Mb of contiguous sequence from chromosome 4 of Arabidopsis
RT thaliana.";
RL Nature 391:485-488(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14993207; DOI=10.1101/gr.1515604;
RA Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M.,
RA Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M.,
RA Weissenbach J., Salanoubat M.;
RT "Whole genome sequence comparisons and 'full-length' cDNA sequences: a
RT combined approach to evaluate and improve Arabidopsis genome annotation.";
RL Genome Res. 14:406-413(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC superfamily. Plant drug/metabolite exporter (P-DME) (TC 2.A.7.4)
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BX829136; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC Sequence=CAB10437.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB78704.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Z97341; CAB10437.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161544; CAB78704.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE83777.1; -; Genomic_DNA.
DR EMBL; BX829136; -; NOT_ANNOTATED_CDS; mRNA.
DR PIR; C71433; C71433.
DR RefSeq; NP_193395.3; NM_117763.5.
DR AlphaFoldDB; F4JMI7; -.
DR SMR; F4JMI7; -.
DR BioGRID; 12656; 36.
DR IntAct; F4JMI7; 36.
DR STRING; 3702.AT4G16620.1; -.
DR PaxDb; F4JMI7; -.
DR EnsemblPlants; AT4G16620.1; AT4G16620.1; AT4G16620.
DR GeneID; 827363; -.
DR Gramene; AT4G16620.1; AT4G16620.1; AT4G16620.
DR KEGG; ath:AT4G16620; -.
DR Araport; AT4G16620; -.
DR TAIR; locus:2130908; AT4G16620.
DR eggNOG; ENOG502QVME; Eukaryota.
DR HOGENOM; CLU_025359_1_2_1; -.
DR InParanoid; F4JMI7; -.
DR OMA; TCFSAWV; -.
DR OrthoDB; 964282at2759; -.
DR PRO; PR:F4JMI7; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; F4JMI7; baseline and differential.
DR Genevisible; F4JMI7; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR000620; EamA_dom.
DR InterPro; IPR030184; WAT1-related.
DR PANTHER; PTHR31218; PTHR31218; 1.
DR Pfam; PF00892; EamA; 2.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT CHAIN 1..359
FT /note="WAT1-related protein At4g16620"
FT /id="PRO_0000421341"
FT TRANSMEM 5..25
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..125
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 183..203
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 246..266
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 279..299
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 305..325
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 30..154
FT /note="EamA 1"
FT DOMAIN 206..324
FT /note="EamA 2"
FT CONFLICT 90
FT /note="F -> Y (in Ref. 4; BX829136)"
FT /evidence="ECO:0000305"
FT CONFLICT 103
FT /note="A -> T (in Ref. 4; BX829136)"
FT /evidence="ECO:0000305"
FT CONFLICT 112
FT /note="L -> F (in Ref. 4; BX829136)"
FT /evidence="ECO:0000305"
FT CONFLICT 174..175
FT /note="DE -> YV (in Ref. 4; BX829136)"
FT /evidence="ECO:0000305"
FT CONFLICT 198
FT /note="S -> F (in Ref. 4; BX829136)"
FT /evidence="ECO:0000305"
FT CONFLICT 229
FT /note="V -> L (in Ref. 4; BX829136)"
FT /evidence="ECO:0000305"
FT CONFLICT 234
FT /note="A -> V (in Ref. 4; BX829136)"
FT /evidence="ECO:0000305"
FT CONFLICT 268
FT /note="S -> I (in Ref. 4; BX829136)"
FT /evidence="ECO:0000305"
FT CONFLICT 283..298
FT /note="SLFSPIATVVCVVVSA -> CVLRRMAILVCFVVSV (in Ref. 4;
FT BX829136)"
FT /evidence="ECO:0000305"
FT CONFLICT 312
FT /note="G -> V (in Ref. 4; BX829136)"
FT /evidence="ECO:0000305"
FT CONFLICT 348
FT /note="R -> S (in Ref. 4; BX829136)"
FT /evidence="ECO:0000305"
FT CONFLICT 357
FT /note="L -> V (in Ref. 4; BX829136)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 359 AA; 38311 MW; 6475BD4D1598CA3E CRC64;
MMKRETLIEA GIIGGLAGAQ VIYAGNSELL SQLLSLGIDP LLIVILCTFA SVLLITPLAF
LLERKLWPRS LSFKLKIKLV LVALAGVTLF QGLFLEGMKH TSASMATAMP NLCPAFIFVI
AWAAGMEKVK LSCMYSRVKM GGTVLCVMGA LIMSLMHSTT ATLSSVKTIP IVPDEVVVDK
DKILGCLYLL LAICGLSSSI VLQASILAEF PAPISMFSMV SLMGGITTVA LQYALKGSME
MGSASVIGLG HLVGYAILGG LVSGGGLSFN AWVIKRKGPV IVSLFSPIAT VVCVVVSAFT
MEESFNLGSF AGMALMFGGL YFVLWAKGKE DCEEIDEMKQ DDEESLLRTE FDLQKPLLL
