WTR36_ARATH
ID WTR36_ARATH Reviewed; 359 AA.
AC Q9SUD5;
DT 06-MAR-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=WAT1-related protein At4g28040;
GN OrderedLocusNames=At4g28040; ORFNames=T13J8.150;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia; TISSUE=Rosette leaf;
RX PubMed=19423640; DOI=10.1093/dnares/dsp009;
RA Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M.,
RA Shinozaki K.;
RT "Analysis of multiple occurrences of alternative splicing events in
RT Arabidopsis thaliana using novel sequenced full-length cDNAs.";
RL DNA Res. 16:155-164(2009).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC superfamily. Plant drug/metabolite exporter (P-DME) (TC 2.A.7.4)
CC family. {ECO:0000305}.
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DR EMBL; AL035524; CAB36773.1; -; Genomic_DNA.
DR EMBL; AL161572; CAB79606.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE85426.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE85427.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE85428.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE85429.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE85430.1; -; Genomic_DNA.
DR EMBL; AF370525; AAK48952.1; -; mRNA.
DR EMBL; AY081516; AAM10078.1; -; mRNA.
DR EMBL; AK317378; BAH20049.1; -; mRNA.
DR PIR; T02905; T02905.
DR RefSeq; NP_001031735.1; NM_001036658.3.
DR RefSeq; NP_001031736.1; NM_001036659.2.
DR RefSeq; NP_001119071.1; NM_001125599.1.
DR RefSeq; NP_194533.1; NM_118943.6.
DR RefSeq; NP_974628.1; NM_202899.2.
DR AlphaFoldDB; Q9SUD5; -.
DR BioGRID; 14206; 5.
DR IntAct; Q9SUD5; 5.
DR STRING; 3702.AT4G28040.4; -.
DR PaxDb; Q9SUD5; -.
DR PRIDE; Q9SUD5; -.
DR ProteomicsDB; 242466; -.
DR EnsemblPlants; AT4G28040.1; AT4G28040.1; AT4G28040.
DR EnsemblPlants; AT4G28040.2; AT4G28040.2; AT4G28040.
DR EnsemblPlants; AT4G28040.3; AT4G28040.3; AT4G28040.
DR EnsemblPlants; AT4G28040.4; AT4G28040.4; AT4G28040.
DR EnsemblPlants; AT4G28040.5; AT4G28040.5; AT4G28040.
DR GeneID; 828919; -.
DR Gramene; AT4G28040.1; AT4G28040.1; AT4G28040.
DR Gramene; AT4G28040.2; AT4G28040.2; AT4G28040.
DR Gramene; AT4G28040.3; AT4G28040.3; AT4G28040.
DR Gramene; AT4G28040.4; AT4G28040.4; AT4G28040.
DR Gramene; AT4G28040.5; AT4G28040.5; AT4G28040.
DR KEGG; ath:AT4G28040; -.
DR Araport; AT4G28040; -.
DR TAIR; locus:2132982; AT4G28040.
DR eggNOG; ENOG502QTZ5; Eukaryota.
DR HOGENOM; CLU_025359_1_1_1; -.
DR InParanoid; Q9SUD5; -.
DR OMA; AWRKENK; -.
DR OrthoDB; 770172at2759; -.
DR PhylomeDB; Q9SUD5; -.
DR PRO; PR:Q9SUD5; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q9SUD5; baseline and differential.
DR Genevisible; Q9SUD5; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR000620; EamA_dom.
DR InterPro; IPR030184; WAT1-related.
DR PANTHER; PTHR31218; PTHR31218; 1.
DR Pfam; PF00892; EamA; 2.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT CHAIN 1..359
FT /note="WAT1-related protein At4g28040"
FT /id="PRO_0000421343"
FT TRANSMEM 10..30
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..86
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..153
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 170..190
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..224
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 266..286
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 292..312
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 18..131
FT /note="EamA 1"
FT DOMAIN 199..310
FT /note="EamA 2"
SQ SEQUENCE 359 AA; 39348 MW; BDDEE39DB3E1C4C9 CRC64;
MEISKYKAVL ALVMLQFTSA GVALFTKAAF MEGLNPTVFV VYRQAIATLF ICPISFISAW
RKENKPSLGV RGFWWVALTA VIGVTVNQNA YFKGIDLSSS SMACAMTNLI PAVTFIISII
VGFESIKRRS MKSVAKVIGT GVCVGGAMAM TFLRGPKLLN ALLNQDNTAW LLGCFFLLIS
TFAWSLWLIL QVPIASHCPD HLYTSACTCF IATIASFLVA LALGNTHLPP WKLDSFLKLS
CCIYSGFQLA ISFFLQAWIV SQKGPVFSAL FNPLSAVIVT FFGALYLKEQ TYLGSLLGAL
AIILGLYIVL WGKSEDYQEE STDLKLENEH NTSSQSDIVS IMIGDKAFRS SELLEPLLM
