WTR38_ARATH
ID WTR38_ARATH Reviewed; 402 AA.
AC Q9FL41;
DT 06-MAR-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=WAT1-related protein At5g07050;
GN OrderedLocusNames=At5g07050; ORFNames=MOJ9.22;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9679202; DOI=10.1093/dnares/5.2.131;
RA Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence
RT features of the regions of 1,381,565 bp covered by twenty one physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:131-145(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-402.
RC STRAIN=cv. Columbia;
RX PubMed=14993207; DOI=10.1101/gr.1515604;
RA Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M.,
RA Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M.,
RA Weissenbach J., Salanoubat M.;
RT "Whole genome sequence comparisons and 'full-length' cDNA sequences: a
RT combined approach to evaluate and improve Arabidopsis genome annotation.";
RL Genome Res. 14:406-413(2004).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC superfamily. Plant drug/metabolite exporter (P-DME) (TC 2.A.7.4)
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BX832761; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AB010697; BAB11163.1; -; Genomic_DNA.
DR EMBL; CP002688; AED91102.1; -; Genomic_DNA.
DR EMBL; BX831593; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BX832761; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; NP_196322.3; NM_120787.3.
DR AlphaFoldDB; Q9FL41; -.
DR STRING; 3702.AT5G07050.1; -.
DR PaxDb; Q9FL41; -.
DR PRIDE; Q9FL41; -.
DR EnsemblPlants; AT5G07050.1; AT5G07050.1; AT5G07050.
DR GeneID; 830596; -.
DR Gramene; AT5G07050.1; AT5G07050.1; AT5G07050.
DR KEGG; ath:AT5G07050; -.
DR Araport; AT5G07050; -.
DR TAIR; locus:2169414; AT5G07050.
DR eggNOG; ENOG502QRHH; Eukaryota.
DR HOGENOM; CLU_025359_1_1_1; -.
DR InParanoid; Q9FL41; -.
DR OMA; IKGSHVN; -.
DR OrthoDB; 718138at2759; -.
DR PhylomeDB; Q9FL41; -.
DR PRO; PR:Q9FL41; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FL41; baseline and differential.
DR Genevisible; Q9FL41; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR000620; EamA_dom.
DR InterPro; IPR030184; WAT1-related.
DR PANTHER; PTHR31218; PTHR31218; 1.
DR Pfam; PF00892; EamA; 2.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT CHAIN 1..402
FT /note="WAT1-related protein At5g07050"
FT /id="PRO_0000421345"
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 48..68
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 74..94
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 109..129
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 149..169
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..216
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 229..249
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 266..286
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 293..313
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 318..338
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 29..159
FT /note="EamA 1"
FT DOMAIN 208..337
FT /note="EamA 2"
FT CONFLICT 76
FT /note="I -> M (in Ref. 3; BX831593)"
FT /evidence="ECO:0000305"
FT CONFLICT 207
FT /note="T -> K (in Ref. 3; BX832761)"
FT /evidence="ECO:0000305"
FT CONFLICT 346
FT /note="V -> E (in Ref. 3; BX832761)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 402 AA; 44356 MW; 3BF4599E3EAD8D21 CRC64;
MSMEEISSCE SFLTSSKPYF AMISLQFGYA GMNIITKISL NTGMSHYVLV VYRHAIATAV
IAPFAFFFER KAQPKITFSI FMQLFILGLL GPVIDQNFYY MGLKYTSPTF SCAMSNMLPA
MTFILAVLFR MEMLDLKKLW CQAKIAGTVV TVAGAMLMTI YKGPIVELFW TKYMHIQDSS
HANTTSSKNS SSDKEFLKGS ILLIFATLAW ASLFVLQAKI LKTYAKHQLS LTTLICFIGT
LQAVAVTFVM EHNPSAWRIG WDMNLLAAAY SGIVASSISY YVQGIVMKKR GPVFATAFSP
LMMVIVAVMG SFVLAEKIFL GGVIGAVLIV IGLYAVLWGK QKENQVTICE LAKIDSNSKV
TEDVEANGSK MKISEGDNSM LSTIVISVPL SETHLKKTIQ EP
