ID   WTR41_ARATH             Reviewed;         370 AA.
AC   F4KHA8; Q9FL09;
DT   06-MAR-2013, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=WAT1-related protein At5g40230;
GN   OrderedLocusNames=At5g40230; ORFNames=MSN9.130;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=9679202; DOI=10.1093/dnares/5.2.131;
RA   Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence
RT   features of the regions of 1,381,565 bp covered by twenty one physically
RT   assigned P1 and TAC clones.";
RL   DNA Res. 5:131-145(1998).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC       superfamily. Plant drug/metabolite exporter (P-DME) (TC 2.A.7.4)
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB10904.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AB010699; BAB10904.1; ALT_INIT; Genomic_DNA.
DR   EMBL; CP002688; AED94522.1; -; Genomic_DNA.
DR   RefSeq; NP_198839.1; NM_123387.3.
DR   AlphaFoldDB; F4KHA8; -.
DR   SMR; F4KHA8; -.
DR   PaxDb; F4KHA8; -.
DR   PRIDE; F4KHA8; -.
DR   EnsemblPlants; AT5G40230.1; AT5G40230.1; AT5G40230.
DR   GeneID; 834021; -.
DR   Gramene; AT5G40230.1; AT5G40230.1; AT5G40230.
DR   KEGG; ath:AT5G40230; -.
DR   Araport; AT5G40230; -.
DR   TAIR; locus:2173752; AT5G40230.
DR   eggNOG; ENOG502RNNC; Eukaryota.
DR   HOGENOM; CLU_025359_0_1_1; -.
DR   InParanoid; F4KHA8; -.
DR   OMA; CIMDETL; -.
DR   OrthoDB; 830100at2759; -.
DR   PRO; PR:F4KHA8; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; F4KHA8; baseline and differential.
DR   Genevisible; F4KHA8; AT.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR000620; EamA_dom.
DR   InterPro; IPR030184; WAT1-related.
DR   PANTHER; PTHR31218; PTHR31218; 1.
DR   Pfam; PF00892; EamA; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT   CHAIN           1..370
FT                   /note="WAT1-related protein At5g40230"
FT                   /id="PRO_0000421348"
FT   TRANSMEM        19..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        51..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        83..103
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        112..132
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        143..163
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        195..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        227..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        260..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        292..311
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        315..337
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          33..162
FT                   /note="EamA 1"
FT   DOMAIN          210..335
FT                   /note="EamA 2"
SQ   SEQUENCE   370 AA;  39949 MW;  A0D1009A215B0DD8 CRC64;
     MTRGAGGETV AWSYFCRDVV PFTAMVAVEC VTVGSNTLFK AATLRGLSFY VFVFYTYVVA
     TLVLLPLSLI FGRSKRLPSA KTPVFFNIFL LALVGFMSLI VGCKGIEYSS PTLASAISNL
     TPAFTFTLAV IFRMEQIVLR SSATQAKIIG TIVSISGALV VILYKGPKVL TDASLTPPSP
     TISLYQHLTS FDSSWIIGGL LLATQYLLVS VWYILQTRVM ELYPEEITVV FLYNLCATLI
     SAPVCLFAEK DLNSFILKPG VSLASVMYSG GLVSSFGSVI HTWGLHLKGP VYISLFKPLS
     IVIAVAMGVM FLGDALYLGS VIGSLILSLG FYTVIWGKAR EDSIKTVAGT EQSPLLPSHT
     IEEEASLSCD