WTR43_ARATH
ID WTR43_ARATH Reviewed; 381 AA.
AC F4KD68; A1A6M0; F4KD70; Q8GW30; Q9FHJ9;
DT 06-MAR-2013, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 64.
DE RecName: Full=WAT1-related protein At5g45370;
GN OrderedLocusNames=At5g45370; ORFNames=MFC19.4;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10470850; DOI=10.1093/dnares/6.3.183;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Kotani H.,
RA Miyajima N., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. IX. Sequence
RT features of the regions of 1,011,550 bp covered by seventeen P1 and TAC
RT clones.";
RL DNA Res. 6:183-195(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RA Bautista V.R., Kim C.J., Chen H., Quinitio C., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=F4KD68-1; Sequence=Displayed;
CC Name=2;
CC IsoId=F4KD68-2; Sequence=VSP_045519;
CC Name=3;
CC IsoId=F4KD68-3; Sequence=VSP_045518;
CC -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC superfamily. Plant drug/metabolite exporter (P-DME) (TC 2.A.7.4)
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB09165.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB018113; BAB09165.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED95239.1; -; Genomic_DNA.
DR EMBL; CP002688; AED95240.1; -; Genomic_DNA.
DR EMBL; CP002688; AED95241.1; -; Genomic_DNA.
DR EMBL; CP002688; ANM69280.1; -; Genomic_DNA.
DR EMBL; AK119116; BAC43687.1; -; mRNA.
DR EMBL; BT029540; ABL66796.1; -; mRNA.
DR RefSeq; NP_001330972.1; NM_001344615.1. [F4KD68-1]
DR RefSeq; NP_199350.2; NM_123905.2. [F4KD68-2]
DR RefSeq; NP_974887.1; NM_203158.2. [F4KD68-1]
DR RefSeq; NP_974888.1; NM_203159.1. [F4KD68-3]
DR AlphaFoldDB; F4KD68; -.
DR STRING; 3702.AT5G45370.2; -.
DR PaxDb; F4KD68; -.
DR ProteomicsDB; 242553; -. [F4KD68-1]
DR EnsemblPlants; AT5G45370.1; AT5G45370.1; AT5G45370. [F4KD68-2]
DR EnsemblPlants; AT5G45370.2; AT5G45370.2; AT5G45370. [F4KD68-1]
DR EnsemblPlants; AT5G45370.3; AT5G45370.3; AT5G45370. [F4KD68-3]
DR EnsemblPlants; AT5G45370.4; AT5G45370.4; AT5G45370. [F4KD68-1]
DR GeneID; 834573; -.
DR Gramene; AT5G45370.1; AT5G45370.1; AT5G45370. [F4KD68-2]
DR Gramene; AT5G45370.2; AT5G45370.2; AT5G45370. [F4KD68-1]
DR Gramene; AT5G45370.3; AT5G45370.3; AT5G45370. [F4KD68-3]
DR Gramene; AT5G45370.4; AT5G45370.4; AT5G45370. [F4KD68-1]
DR KEGG; ath:AT5G45370; -.
DR Araport; AT5G45370; -.
DR TAIR; locus:2163513; AT5G45370.
DR eggNOG; ENOG502QUHA; Eukaryota.
DR InParanoid; F4KD68; -.
DR OMA; VIMRVER; -.
DR PRO; PR:F4KD68; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; F4KD68; baseline and differential.
DR Genevisible; F4KD68; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR000620; EamA_dom.
DR InterPro; IPR030184; WAT1-related.
DR PANTHER; PTHR31218; PTHR31218; 1.
DR Pfam; PF00892; EamA; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Membrane; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..381
FT /note="WAT1-related protein At5g45370"
FT /id="PRO_0000421350"
FT TRANSMEM 26..46
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 49..69
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..132
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..171
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 297..317
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 320..340
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 31..143
FT /note="EamA 1"
FT DOMAIN 225..345
FT /note="EamA 2"
FT VAR_SEQ 72..132
FT /note="RTIRPPMNRSIFFSLFFLGLAGIFGNQLLFLMGLSYTNPTYAAAIQPSIPVF
FT TFLLAVLMG -> S (in isoform 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_045518"
FT VAR_SEQ 171..194
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11910074"
FT /id="VSP_045519"
FT CONFLICT 377..380
FT /note="DETG -> QFSS (in Ref. 4; ABL66796)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 381 AA; 41030 MW; ECC83782923E3F08 CRC64;
MAAPAILNGG DATERETRMA HSAMTLVQVI NGGYHVVTKV ALNVGVNQLV FCVFRDLLAL
SILAPLAFFR ERTIRPPMNR SIFFSLFFLG LAGIFGNQLL FLMGLSYTNP TYAAAIQPSI
PVFTFLLAVL MGTEKVNLLK VEGQTKVGGT LVCVSGAIAM ALFRGPALFG GKDAADSVKS
VIIDRSQPEL NGWLVSSFLG LGFDQWHIGV LCLIGNCMCM AAFLAVQAPV LKKYPAYLSV
AAYSYFFGAS IMITTAILFV REPKDWSLTQ SEVLAVIFAG VFASALNYGL LTWSNKILGA
ALVSLYNPLQ PATSAFLSTI FLGSPIYLGS VLGGILIICG LYMVTWASYR EQQTTSAGNE
IASSSDVRIS EPFIYRDETG K
