ID   WTR45_ARATH             Reviewed;         359 AA.
AC   Q9FGG3;
DT   06-MAR-2013, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=WAT1-related protein At5g64700;
GN   OrderedLocusNames=At5g64700; ORFNames=MVP7.2;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RA   Kaneko T., Katoh T., Asamizu E., Sato S., Nakamura Y., Kotani H.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. XI.";
RL   Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC       superfamily. Plant drug/metabolite exporter (P-DME) (TC 2.A.7.4)
CC       family. {ECO:0000305}.
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DR   EMBL; AB025637; BAB10303.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED97940.1; -; Genomic_DNA.
DR   RefSeq; NP_201275.1; NM_125866.3.
DR   AlphaFoldDB; Q9FGG3; -.
DR   SMR; Q9FGG3; -.
DR   STRING; 3702.AT5G64700.1; -.
DR   PaxDb; Q9FGG3; -.
DR   PRIDE; Q9FGG3; -.
DR   EnsemblPlants; AT5G64700.1; AT5G64700.1; AT5G64700.
DR   GeneID; 836591; -.
DR   Gramene; AT5G64700.1; AT5G64700.1; AT5G64700.
DR   KEGG; ath:AT5G64700; -.
DR   Araport; AT5G64700; -.
DR   TAIR; locus:2176065; AT5G64700.
DR   eggNOG; ENOG502QUJ3; Eukaryota.
DR   HOGENOM; CLU_025359_1_0_1; -.
DR   InParanoid; Q9FGG3; -.
DR   OMA; NDVVCNE; -.
DR   OrthoDB; 1226743at2759; -.
DR   PhylomeDB; Q9FGG3; -.
DR   PRO; PR:Q9FGG3; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q9FGG3; baseline and differential.
DR   Genevisible; Q9FGG3; AT.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR000620; EamA_dom.
DR   InterPro; IPR030184; WAT1-related.
DR   PANTHER; PTHR31218; PTHR31218; 1.
DR   Pfam; PF00892; EamA; 2.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT   CHAIN           1..359
FT                   /note="WAT1-related protein At5g64700"
FT                   /id="PRO_0000421352"
FT   TRANSMEM        10..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        37..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        66..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        186..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        218..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        256..276
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        282..302
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        306..326
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          18..136
FT                   /note="EamA 1"
FT   DOMAIN          198..326
FT                   /note="EamA 2"
SQ   SEQUENCE   359 AA;  39753 MW;  F7AC9D9C9E35F3A8 CRC64;
     MDMESKKPYL MVTIIQVIYT IMFLISKAVF NGGMNTFVFV FYRQAFATIF LAPLAFFFER
     KSAPPLSFVT FIKIFMLSLF GVTLSLDLNG IALSYTSATL AAATTASLPA ITFFLALLFG
     MERLKVKSIQ GTAKLVGITV CMGGVIILAI YKGPLLKLPL CPHFYHGQEH PHRNNPGHVS
     GGSTSWLKGC VLMITSNILW GLWLVLQGRV LKVYPSKLYF TTLHCLLSSI QSFVIAIALE
     RDISAWKLGW NLRLVAVIYC GFIVTGVAYY LQSWVIEKRG PVFLSMFTPL SLLFTLLSSA
     ILLCEIISLG SIVGGLLLII GLYCVLWGKS REEKNSGDDK IDLQKENDVV CNEVKVVIS