WTR4_ARATH
ID WTR4_ARATH Reviewed; 337 AA.
AC F4I8W6; Q9LPY8;
DT 06-MAR-2013, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 55.
DE RecName: Full=WAT1-related protein At1g11460;
GN OrderedLocusNames=At1g11460; ORFNames=T23J18.13;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC superfamily. Plant drug/metabolite exporter (P-DME) (TC 2.A.7.4)
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF16631.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC011661; AAF16631.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE28739.1; -; Genomic_DNA.
DR PIR; C86248; C86248.
DR RefSeq; NP_172613.1; NM_101019.2.
DR AlphaFoldDB; F4I8W6; -.
DR SMR; F4I8W6; -.
DR STRING; 3702.AT1G11460.1; -.
DR PaxDb; F4I8W6; -.
DR PRIDE; F4I8W6; -.
DR EnsemblPlants; AT1G11460.1; AT1G11460.1; AT1G11460.
DR GeneID; 837688; -.
DR Gramene; AT1G11460.1; AT1G11460.1; AT1G11460.
DR KEGG; ath:AT1G11460; -.
DR Araport; AT1G11460; -.
DR TAIR; locus:2200041; AT1G11460.
DR eggNOG; ENOG502QWIP; Eukaryota.
DR HOGENOM; CLU_025359_1_0_1; -.
DR InParanoid; F4I8W6; -.
DR OMA; KDWIIDD; -.
DR OrthoDB; 888469at2759; -.
DR PRO; PR:F4I8W6; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; F4I8W6; baseline and differential.
DR Genevisible; F4I8W6; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR000620; EamA_dom.
DR InterPro; IPR030184; WAT1-related.
DR PANTHER; PTHR31218; PTHR31218; 1.
DR Pfam; PF00892; EamA; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT CHAIN 1..337
FT /note="WAT1-related protein At1g11460"
FT /id="PRO_0000421312"
FT TRANSMEM 14..34
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 46..66
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 83..103
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..208
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 220..240
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 254..274
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 284..304
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 309..329
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 27..157
FT /note="EamA 1"
FT DOMAIN 220..328
FT /note="EamA 2"
SQ SEQUENCE 337 AA; 36976 MW; 35244E61F29A068C CRC64;
MGEDMRVVKV ESKWPPIIVM VISQVAMGSV NALVKKALDV GVNHMIIGAY RIAISSFILA
PIAYILEREI IPEITFRLMV DHFISGLLGA SLMQFFYLLG LSYTSATVAC ALVSLMPAIT
FAFALILRTE KIKSLRTQAG MIKVMGTIIC ISGALFLTFY KGPHISNSHS HQEALPHNNN
SDHNTKNWLL GCLYLTIGTV LISLWILFQG TLSIKYPCKF SSTCLMSIFA AFQCALLSLY
KSRDVKDWII DDRFVIGVIV YAGVIGQAMS TVSVTWGVKK LGAVFVSAIM PIALISASLF
DFIILHTPLY LGSLIGSVGT ITGLYVFLWG KNKDMEA
