WTR5_ARATH
ID WTR5_ARATH Reviewed; 389 AA.
AC F4HZQ7; Q8VZ54; Q9SFE7;
DT 06-MAR-2013, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 55.
DE RecName: Full=WAT1-related protein At1g21890;
GN OrderedLocusNames=At1g21890; ORFNames=T26F17.11;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC superfamily. Plant drug/metabolite exporter (P-DME) (TC 2.A.7.4)
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF16542.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC013482; AAF16542.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE30169.1; -; Genomic_DNA.
DR EMBL; AY065236; AAL38712.1; -; mRNA.
DR EMBL; AY133841; AAM91775.1; -; mRNA.
DR RefSeq; NP_173607.1; NM_102037.3.
DR AlphaFoldDB; F4HZQ7; -.
DR SMR; F4HZQ7; -.
DR BioGRID; 24030; 8.
DR IntAct; F4HZQ7; 8.
DR STRING; 3702.AT1G21890.1; -.
DR PaxDb; F4HZQ7; -.
DR PRIDE; F4HZQ7; -.
DR EnsemblPlants; AT1G21890.1; AT1G21890.1; AT1G21890.
DR GeneID; 838791; -.
DR Gramene; AT1G21890.1; AT1G21890.1; AT1G21890.
DR KEGG; ath:AT1G21890; -.
DR Araport; AT1G21890; -.
DR TAIR; locus:2201148; AT1G21890.
DR eggNOG; ENOG502QQ3S; Eukaryota.
DR HOGENOM; CLU_025359_1_1_1; -.
DR InParanoid; F4HZQ7; -.
DR OMA; WTKNANH; -.
DR OrthoDB; 763588at2759; -.
DR PRO; PR:F4HZQ7; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; F4HZQ7; baseline and differential.
DR Genevisible; F4HZQ7; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR000620; EamA_dom.
DR InterPro; IPR030184; WAT1-related.
DR PANTHER; PTHR31218; PTHR31218; 1.
DR Pfam; PF00892; EamA; 2.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT CHAIN 1..389
FT /note="WAT1-related protein At1g21890"
FT /id="PRO_0000421313"
FT TRANSMEM 13..33
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 102..122
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 225..245
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 260..280
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 287..307
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 312..332
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 23..150
FT /note="EamA 1"
FT DOMAIN 205..331
FT /note="EamA 2"
FT REGION 339..361
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 121
FT /note="I -> N (in Ref. 3; AAL38712/AAM91775)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 389 AA; 41715 MW; 136C7B056300300E CRC64;
MGRGLMNSLK PYLAMISMQF GYAGMYIITM VSLKHGMNHY VLAVYRHAIA TAVIAPFALF
HERKIRPKMT FRIFLQIALL GFIEPVLDQN LYYVGMTYTS ATFASATANV LPAITFVLAI
IFRLESVNFK KVRSIAKVVG TVITVSGALL MTLYKGPIVD FIRFGGGGGG GSDGAGGSHG
GAGAAAMDKH WIPGTLMLLG RTFGWAGFFI LQSFTLKQYP AELSLTTLIC LMGTLEGTAV
SLVTVRDLSA WKIGFDSNLF AAAYSGVICS GVAYYVQGVV MRERGPVFVA TFNPLCVVIT
AALGVVVLSE SIHLGSVIGT LFIIVGLYTV VWGKGKDKRM TDDDEDCKGL PIKSPVKPVD
TGKGLAAELE MKSKEGQEAK ATTTTQVEI
