WTR6_ARATH
ID WTR6_ARATH Reviewed; 355 AA.
AC Q4PT23; Q9FRH6;
DT 06-MAR-2013, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=WAT1-related protein At1g25270;
GN OrderedLocusNames=At1g25270; ORFNames=F4F7.34;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W.,
RA Redman J.C., Wu H.C., Utterback T., Town C.D.;
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC superfamily. Plant drug/metabolite exporter (P-DME) (TC 2.A.7.4)
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG40088.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC079374; AAG40088.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE30595.1; -; Genomic_DNA.
DR EMBL; DQ056463; AAY78620.1; -; mRNA.
DR RefSeq; NP_173898.2; NM_102336.2.
DR AlphaFoldDB; Q4PT23; -.
DR STRING; 3702.AT1G25270.1; -.
DR TCDB; 2.A.7.4.2; the drug/metabolite transporter (dmt) superfamily.
DR PaxDb; Q4PT23; -.
DR PRIDE; Q4PT23; -.
DR EnsemblPlants; AT1G25270.1; AT1G25270.1; AT1G25270.
DR GeneID; 839110; -.
DR Gramene; AT1G25270.1; AT1G25270.1; AT1G25270.
DR KEGG; ath:AT1G25270; -.
DR Araport; AT1G25270; -.
DR TAIR; locus:2032960; AT1G25270.
DR eggNOG; ENOG502QR4Y; Eukaryota.
DR HOGENOM; CLU_025359_1_0_1; -.
DR InParanoid; Q4PT23; -.
DR OMA; TFVIAIC; -.
DR OrthoDB; 1012755at2759; -.
DR PhylomeDB; Q4PT23; -.
DR PRO; PR:Q4PT23; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q4PT23; baseline and differential.
DR Genevisible; Q4PT23; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR000620; EamA_dom.
DR InterPro; IPR030184; WAT1-related.
DR PANTHER; PTHR31218; PTHR31218; 1.
DR Pfam; PF00892; EamA; 2.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT CHAIN 1..355
FT /note="WAT1-related protein At1g25270"
FT /id="PRO_0000421314"
FT TRANSMEM 4..24
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..85
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 134..154
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 207..227
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 297..317
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 12..142
FT /note="EamA 1"
FT DOMAIN 210..316
FT /note="EamA 2"
SQ SEQUENCE 355 AA; 38576 MW; 3365E32D6382E872 CRC64;
MKSVVAMVAV QFIFAGMFIL FKITVDDGTN LKVLVAYRLS FATIFMLPLA LIFQRKKRPE
FTWRLLLLAF VSGLLGAAIP NILYLPGMAR TSATFSAASS IISPLITLVL GLVFRMETLR
LGSNEGRAKL VGTLLGACGA LVFVFYKGIE IHIWSTHVDL LKGSHTGRAT TNHHVSILGV
LMVLGSNVST SLWLLLQAKI GKELGGLYWN TSLMNGVGSL VCVIIALCSD HDWEQWQLGW
DINLLATLYS GIVVSGMVVP LVAWCIATKG PLFVTVFSPI RLVIVALIGS FALEEPLHLG
SIIGAMIMVG GVYLVVWCKM KEKKSASTTS DHIETNKNNK ELDLGNLSSV NRDVP
