ID   WTR7_ARATH              Reviewed;         343 AA.
AC   Q6NMB7;
DT   06-MAR-2013, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=WAT1-related protein At1g43650;
GN   OrderedLocusNames=At1g43650; ORFNames=F2J6.1;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Cheuk R.F., Chen H., Kim C.J., Shinn P., Carninci P., Hayashizaki Y.,
RA   Ishida J., Kamiya A., Kawai J., Narusaka M., Sakurai T., Satou M., Seki M.,
RA   Shinozaki K., Ecker J.R.;
RT   "Arabidopsis ORF clones.";
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA   Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=1;
CC         Comment=Additional isoforms seem to exist.;
CC       Name=1;
CC         IsoId=Q6NMB7-1; Sequence=Displayed;
CC   -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC       superfamily. Plant drug/metabolite exporter (P-DME) (TC 2.A.7.4)
CC       family. {ECO:0000305}.
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DR   EMBL; CP002684; AEE31980.1; -; Genomic_DNA.
DR   EMBL; BT011743; AAS49106.1; -; mRNA.
DR   EMBL; AK176218; BAD43981.1; -; mRNA.
DR   RefSeq; NP_175030.2; NM_103490.4. [Q6NMB7-1]
DR   AlphaFoldDB; Q6NMB7; -.
DR   SMR; Q6NMB7; -.
DR   STRING; 3702.AT1G43650.1; -.
DR   PaxDb; Q6NMB7; -.
DR   EnsemblPlants; AT1G43650.1; AT1G43650.1; AT1G43650. [Q6NMB7-1]
DR   GeneID; 840949; -.
DR   Gramene; AT1G43650.1; AT1G43650.1; AT1G43650. [Q6NMB7-1]
DR   KEGG; ath:AT1G43650; -.
DR   Araport; AT1G43650; -.
DR   TAIR; locus:2031144; AT1G43650.
DR   eggNOG; ENOG502QUJ3; Eukaryota.
DR   HOGENOM; CLU_025359_1_0_1; -.
DR   InParanoid; Q6NMB7; -.
DR   OMA; TESICIR; -.
DR   OrthoDB; 1226743at2759; -.
DR   PhylomeDB; Q6NMB7; -.
DR   PRO; PR:Q6NMB7; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q6NMB7; baseline and differential.
DR   Genevisible; Q6NMB7; AT.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR000620; EamA_dom.
DR   InterPro; IPR030184; WAT1-related.
DR   PANTHER; PTHR31218; PTHR31218; 1.
DR   Pfam; PF00892; EamA; 2.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Membrane; Reference proteome; Repeat; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..343
FT                   /note="WAT1-related protein At1g43650"
FT                   /id="PRO_0000421315"
FT   TRANSMEM        9..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        65..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        130..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        175..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        209..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        296..316
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          16..139
FT                   /note="EamA 1"
FT   DOMAIN          188..313
FT                   /note="EamA 2"
SQ   SEQUENCE   343 AA;  37715 MW;  1E2871FCF6711231 CRC64;
     MMMEHKANMA MVFVQIVYAG MPLLSKVAIS QGTNPFVFVF YRQAFAALAL SPFAFFLESS
     KSSPLSFILL LKIFFISLCG LTLSLNLYYV AIENTTATFA AATTNAIPSI TFVLALLFRL
     ETVTLKKSHG VAKVTGSMVG MLGALVFAFV KGPSLINHYN SSTIPNGTVP STKNSVKGSI
     TMLAANTCWC LWIIMQSKVM KEYPAKLRLV ALQCLFSCIQ SAVWAVAVNR NPSVWKIEFG
     LPLLSMAYCG IMVTGLTYWL QVWAIEKKGP VFTALYTPLA LILTCIVSSF LFKETFYLGS
     VGGAVLLVCG LYLGLWGKTK EEEIQRYGEK QSQKEIIEEV IIV