ID   WTR9_ARATH              Reviewed;         374 AA.
AC   Q9ZUI8;
DT   06-MAR-2013, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=WAT1-related protein At1g60050;
GN   OrderedLocusNames=At1g60050; ORFNames=T2K10.10;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the drug/metabolite transporter (DMT)
CC       superfamily. Plant drug/metabolite exporter (P-DME) (TC 2.A.7.4)
CC       family. {ECO:0000305}.
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DR   EMBL; AC005966; AAD14481.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE33653.1; -; Genomic_DNA.
DR   PIR; H96624; H96624.
DR   RefSeq; NP_176213.1; NM_104697.2.
DR   AlphaFoldDB; Q9ZUI8; -.
DR   BioGRID; 27524; 6.
DR   IntAct; Q9ZUI8; 6.
DR   TCDB; 2.A.7.4.3; the drug/metabolite transporter (dmt) superfamily.
DR   PaxDb; Q9ZUI8; -.
DR   PRIDE; Q9ZUI8; -.
DR   EnsemblPlants; AT1G60050.1; AT1G60050.1; AT1G60050.
DR   GeneID; 842299; -.
DR   Gramene; AT1G60050.1; AT1G60050.1; AT1G60050.
DR   KEGG; ath:AT1G60050; -.
DR   Araport; AT1G60050; -.
DR   TAIR; locus:2202745; AT1G60050.
DR   eggNOG; ENOG502QW2M; Eukaryota.
DR   HOGENOM; CLU_025359_0_1_1; -.
DR   InParanoid; Q9ZUI8; -.
DR   OMA; MEARWEN; -.
DR   OrthoDB; 705112at2759; -.
DR   PhylomeDB; Q9ZUI8; -.
DR   PRO; PR:Q9ZUI8; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q9ZUI8; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR000620; EamA_dom.
DR   InterPro; IPR030184; WAT1-related.
DR   PANTHER; PTHR31218; PTHR31218; 1.
DR   Pfam; PF00892; EamA; 1.
PE   3: Inferred from homology;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..374
FT                   /note="WAT1-related protein At1g60050"
FT                   /id="PRO_0000421317"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        42..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        107..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        145..165
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        194..214
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        228..248
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        255..275
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        292..312
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        315..335
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          26..155
FT                   /note="EamA"
SQ   SEQUENCE   374 AA;  41135 MW;  B9C9C8225B4C4D09 CRC64;
     MGLMDTRWET IVPFIVMALM EACTIALTIL AKTALTGGMS PFVFIVYTNA LGSLLLLPYS
     FYFHRDESDD EPFLTKPSLV RIFLLGFTGV FLFQNMAFLG LSYSSPIVVC AMGLQSPAFS
     FLLSLALGKE GGLGWASKRT KGRVIGTLIC FTGAFVEVIY LGPFIRPSPP SSPTSNFLTT
     ISHYLTFFKN SDNWALGSLL LACATLSISI WNIIQLDTVQ KYPQVMKVVS AYSLAGTLQC
     AIFSAFMEPD LSAWELKLNM DLYLIIATGI FGSIIRTSVQ VKCSKMKGPY YVPLFKPFGI
     LWASIFGTSF FVNSLHYGSV LGAAIAGTGY LLIMWSQVQK DDPNETVEKN DNHQLDSDEQ
     TTPLLLANGD FDQV