ID   WUS_ANTMA               Reviewed;         281 AA.
AC   Q6YBV1;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Protein WUSCHEL;
DE   AltName: Full=Protein ROSULATA;
GN   Name=WUS; Synonyms=ROA;
OS   Antirrhinum majus (Garden snapdragon).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Lamiales; Plantaginaceae; Antirrhineae; Antirrhinum.
OX   NCBI_TaxID=4151;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Flower;
RA   Kieffer M.L., Davies B.H.;
RT   "ROSULATA controls Antirrhinum meristem maintenance.";
RL   Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor that plays a central role during
CC       developmental processes such as early embryogenesis and flowering,
CC       probably by regulating expression of specific genes. Required to
CC       specify stem cell identity in meristems, such as shoot apical meristem
CC       (SAM). May induce shoot stem cells activity in order to maintain the
CC       stem cell identity (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the WUS homeobox family. {ECO:0000305}.
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DR   EMBL; AY162209; AAO23113.1; -; mRNA.
DR   AlphaFoldDB; Q6YBV1; -.
DR   SMR; Q6YBV1; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0009908; P:flower development; IEA:UniProtKB-KW.
DR   GO; GO:0099402; P:plant organ development; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR044555; WUSCHEL-like.
DR   PANTHER; PTHR45940; PTHR45940; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; DNA-binding; Flowering; Homeobox;
KW   Nucleus; Transcription; Transcription regulation.
FT   CHAIN           1..281
FT                   /note="Protein WUSCHEL"
FT                   /id="PRO_0000049382"
FT   DNA_BIND        36..101
FT                   /note="Homeobox; WUS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   281 AA;  32027 MW;  D7AD62CE3E9172FA CRC64;
     MEPQQQQQQQ GNEQQDSQGI GKINNGSGGS SFLCRQSSTR WTPTTDQIRI LKDLYYNNGV
     RSPTAEQIQR ISAKLRQYGK IEGKNVFYWF QNHKARERQK KRFTADHHHH MNVPTIHNHH
     YKPPPVYNKF SNMNSGSFPS SSNGSPGFLT TPGSHVGNYG YGSVAMEKSF RECTISSTTD
     ANVGGSMSQN IAWIGINNEY HNPYTFIDTR KYMNGYDQTL EIEEEAEENY TAEIETLPLF
     PMHADIKQDT ADYFNGRLEN GCPRASLELT LNSWFGNSKY N