ID   WUS_PETHY               Reviewed;         307 AA.
AC   Q8LL11;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Protein WUSCHEL;
DE   AltName: Full=PhWUS;
DE   AltName: Full=Protein TERMINATOR;
GN   Name=WUS; Synonyms=TER;
OS   Petunia hybrida (Petunia).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Petunioideae; Petunia.
OX   NCBI_TaxID=4102;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC   STRAIN=cv. W138;
RX   PubMed=12208843; DOI=10.1101/gad.230702;
RA   Stuurman J., Jaeggi F., Kuhlemeier C.;
RT   "Shoot meristem maintenance is controlled by a GRAS-gene mediated signal
RT   from differentiating cells.";
RL   Genes Dev. 16:2213-2218(2002).
CC   -!- FUNCTION: Transcription factor that plays a central role during
CC       developmental processes such as early embryogenesis and flowering,
CC       probably by regulating expression of specific genes. Required to
CC       specify stem cell identity in meristems, such as shoot apical meristem
CC       (SAM). Acts in parallel with HAM. {ECO:0000269|PubMed:12208843}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- TISSUE SPECIFICITY: In the active shoot meristem, it is specifically
CC       expressed in a small cell group underneath the presume position of stem
CC       cells. {ECO:0000269|PubMed:12208843}.
CC   -!- SIMILARITY: Belongs to the WUS homeobox family. {ECO:0000305}.
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DR   EMBL; AF481951; AAM90847.1; -; mRNA.
DR   AlphaFoldDB; Q8LL11; -.
DR   SMR; Q8LL11; -.
DR   IntAct; Q8LL11; 1.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0009908; P:flower development; IEA:UniProtKB-KW.
DR   GO; GO:0099402; P:plant organ development; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR044555; WUSCHEL-like.
DR   PANTHER; PTHR45940; PTHR45940; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; DNA-binding; Flowering; Homeobox;
KW   Nucleus; Transcription; Transcription regulation.
FT   CHAIN           1..307
FT                   /note="Protein WUSCHEL"
FT                   /id="PRO_0000049385"
FT   DNA_BIND        43..108
FT                   /note="Homeobox; WUS-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          23..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   307 AA;  35115 MW;  EC91D89A03647059 CRC64;
     METAQHQQNN QQHYLHQHLS IGQGTNIEDG SNKNNSSNFM CRQNSTRWTP TTDQIRILKD
     LYYNNGVRSP TAEQIQRISA KLRQYGKIEG KNVFYWFQNH KARERQKKRL IAAATTDNTN
     LPMQMQFQRG VWRSSADDPI HHKYTNPGVH CPSASSHGVL AVGQNGNHGY GALAMEKSFR
     DCSISPGSSM SHHHHQNFAW AGVDPYSSTT TYPFLEKTKH FENETLEADE EQQEEDQENY
     YYQRTTSAIE TLPLFPMHEE NISSFCNLKH QESSGGFYTE WYRADDNLAA ARASLELSLN
     SFIGNSS