ID   WWC2_XENTR              Reviewed;        1171 AA.
AC   Q6DJR2;
DT   13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Protein WWC2;
DE   AltName: Full=WW domain-containing protein 2;
GN   Name=wwc2;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the WWC family. {ECO:0000305}.
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DR   EMBL; BC075112; AAH75112.1; -; mRNA.
DR   RefSeq; NP_001004872.1; NM_001004872.1.
DR   AlphaFoldDB; Q6DJR2; -.
DR   SMR; Q6DJR2; -.
DR   STRING; 8364.ENSXETP00000030868; -.
DR   PaxDb; Q6DJR2; -.
DR   PRIDE; Q6DJR2; -.
DR   GeneID; 448191; -.
DR   KEGG; xtr:448191; -.
DR   CTD; 80014; -.
DR   Xenbase; XB-GENE-1001637; wwc2.
DR   eggNOG; KOG3209; Eukaryota.
DR   InParanoid; Q6DJR2; -.
DR   OrthoDB; 364990at2759; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0019900; F:kinase binding; IBA:GO_Central.
DR   GO; GO:0060090; F:molecular adaptor activity; IBA:GO_Central.
DR   GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR   GO; GO:0046621; P:negative regulation of organ growth; IBA:GO_Central.
DR   GO; GO:0035330; P:regulation of hippo signaling; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   CDD; cd08680; C2_Kibra; 1.
DR   CDD; cd00201; WW; 2.
DR   Gene3D; 2.60.40.150; -; 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR037771; C2_WWC.
DR   InterPro; IPR001202; WW_dom.
DR   InterPro; IPR036020; WW_dom_sf.
DR   Pfam; PF00397; WW; 2.
DR   SMART; SM00456; WW; 2.
DR   SUPFAM; SSF49562; SSF49562; 1.
DR   SUPFAM; SSF51045; SSF51045; 2.
DR   PROSITE; PS50004; C2; 1.
DR   PROSITE; PS01159; WW_DOMAIN_1; 1.
DR   PROSITE; PS50020; WW_DOMAIN_2; 2.
PE   2: Evidence at transcript level;
KW   Coiled coil; Reference proteome; Repeat.
FT   CHAIN           1..1171
FT                   /note="Protein WWC2"
FT                   /id="PRO_0000309492"
FT   DOMAIN          9..42
FT                   /note="WW 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00224"
FT   DOMAIN          56..89
FT                   /note="WW 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00224"
FT   DOMAIN          684..806
FT                   /note="C2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT   REGION          521..552
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          603..637
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          120..193
FT                   /evidence="ECO:0000255"
FT   COILED          223..257
FT                   /evidence="ECO:0000255"
FT   COILED          301..420
FT                   /evidence="ECO:0000255"
FT   COILED          836..870
FT                   /evidence="ECO:0000255"
FT   COILED          1047..1123
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1171 AA;  132392 MW;  749A43A2960DC0EA CRC64;
     MPRKGNGQLP LPDGWEEARD YDGKVFYIDH NSRQTSWIDP RDRLTKPLSF ADCVGNELPW
     GWESSYDPQI GVYFINHINQ TTQIEDPRKL WRNEQERMLK DYLMVAQDAL STQKELYHIK
     EQRLALALDE YVRLNDAYKE KSSSRTSLFS GSSSSTKYDP DILKAEISTT KVRVKKLKRE
     LSQMKQELLY KEQGFETLQR IDQKMSGGQS GYELREAKDI LSELKSIRKA ISTGEKEKQD
     LMQSLVKLKE RFHLEEARGR SEPDLRSNLA NSHLSLSRQT LDAGSQTDIS GDIGVRSRSN
     LAEKVRLSLQ YEEAKRSMAN LKIELAKLDS EAWPGALDVE KEKLMLINEK EELLKELQFV
     TTRRRTQGEI ERLEGERRRL EEELLSVKSS PSKALAEQLK IQEKKKELVK KLEEVTKSAT
     YLHSQLKSLS ASTLSVSSGS SIGSLASSRG SLNTSSRGSL NSLSSTDLYY NQNEPAADLD
     YQYKLDFLLQ EKSGYIPCGP ITTIHENEVV HCHERIDYTN SPTAQQDTQD AKPPKSVTSL
     SSLSSLSSLS PPGSPPVLEG VFSLCTQDSL RTGFEISELP ESFADMNLHE NLQLMESVAG
     ESQALAERKS TGEGLRHQSS ASQEGRTDIE FPRKNPDRVQ EEKAMCVSAA VSDESVAGDS
     GVYEPSVKPP GEDPVFNDDY SILGAAQAQL ILRYDSGNSS FVIIIVKARN NLSYVQFGSR
     IYFRVAVLPS SNDTSCLFRT KVYPATESVL FNELFRVSIS QTTLQQKTLR VDMCSVGKTH
     REDCLAGTQI SLADFSFSND VHTQWYTLLP SRTIPLHKEQ LEKSVLSASN TQTAALDLDA
     VSALLERTSA ELEAVEQELA QEDDDQEQLC PGDDWPEMAP EESFSTLEEH EADLLLSGEY
     YAVPLQLSSE TTEKSEELYG ETSNWDSVVS PLPQAELPTL VDKETNTEEA LQENLSVRPK
     ERANLGSRQR PFVRNSMIVR SQTFSPGEKN QYICRLNRSD SDSSTLAKKS PFIRNANERR
     SLRVKRPICQ PMTRRTVHEC RERTSLDLEL DLQASLTRQS RLNDELQSLR DLKQRLEEMK
     ARGETELPTC VLEDERFQRL LKQAEKQAEQ SKEEQKQGLN AEKLMRKASK DVCRLREQSQ
     KVPLQVQSFR EKITYFTRAK ISIPSLSADD V