WWC3_HUMAN
ID WWC3_HUMAN Reviewed; 1092 AA.
AC Q9ULE0; A8KA96; Q659C1; Q9BTQ1;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2007, sequence version 3.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Protein WWC3;
GN Name=WWC3; Synonyms=KIAA1280;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15772651; DOI=10.1038/nature03440;
RA Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA Rogers J., Bentley D.R.;
RT "The DNA sequence of the human X chromosome.";
RL Nature 434:325-337(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 61-1092 (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=10574462; DOI=10.1093/dnares/6.5.337;
RA Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XV. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 6:337-345(1999).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 109-1092 (ISOFORM 2).
RC TISSUE=Amygdala;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 876-1092 (ISOFORM 1).
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9ULE0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9ULE0-2; Sequence=VSP_029220, VSP_029221;
CC -!- SIMILARITY: Belongs to the WWC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION: [Isoform 2]:
CC Sequence=CAH56367.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK292961; BAF85650.1; -; mRNA.
DR EMBL; AC002359; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC002364; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC121345; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AB033106; BAA86594.1; -; mRNA.
DR EMBL; AL353937; CAH56367.1; ALT_FRAME; mRNA.
DR EMBL; CH471074; EAW98775.1; -; Genomic_DNA.
DR EMBL; BC003527; AAH03527.1; -; mRNA.
DR RefSeq; NP_056506.2; NM_015691.3. [Q9ULE0-1]
DR AlphaFoldDB; Q9ULE0; -.
DR SMR; Q9ULE0; -.
DR BioGRID; 120944; 21.
DR IntAct; Q9ULE0; 3.
DR STRING; 9606.ENSP00000370242; -.
DR iPTMnet; Q9ULE0; -.
DR PhosphoSitePlus; Q9ULE0; -.
DR BioMuta; WWC3; -.
DR DMDM; 160261727; -.
DR EPD; Q9ULE0; -.
DR jPOST; Q9ULE0; -.
DR MassIVE; Q9ULE0; -.
DR MaxQB; Q9ULE0; -.
DR PaxDb; Q9ULE0; -.
DR PeptideAtlas; Q9ULE0; -.
DR PRIDE; Q9ULE0; -.
DR ProteomicsDB; 85006; -. [Q9ULE0-1]
DR ProteomicsDB; 85007; -. [Q9ULE0-2]
DR Antibodypedia; 49640; 80 antibodies from 18 providers.
DR DNASU; 55841; -.
DR Ensembl; ENST00000380861.10; ENSP00000370242.6; ENSG00000047644.20.
DR GeneID; 55841; -.
DR KEGG; hsa:55841; -.
DR UCSC; uc004csx.5; human. [Q9ULE0-1]
DR CTD; 55841; -.
DR DisGeNET; 55841; -.
DR GeneCards; WWC3; -.
DR HGNC; HGNC:29237; WWC3.
DR HPA; ENSG00000047644; Low tissue specificity.
DR neXtProt; NX_Q9ULE0; -.
DR PharmGKB; PA143485672; -.
DR VEuPathDB; HostDB:ENSG00000047644; -.
DR eggNOG; KOG3209; Eukaryota.
DR InParanoid; Q9ULE0; -.
DR OMA; HSGFHKQ; -.
DR OrthoDB; 364990at2759; -.
DR PhylomeDB; Q9ULE0; -.
DR TreeFam; TF324040; -.
DR PathwayCommons; Q9ULE0; -.
DR SignaLink; Q9ULE0; -.
DR BioGRID-ORCS; 55841; 3 hits in 694 CRISPR screens.
DR ChiTaRS; WWC3; human.
DR GenomeRNAi; 55841; -.
DR Pharos; Q9ULE0; Tbio.
DR PRO; PR:Q9ULE0; -.
DR Proteomes; UP000005640; Chromosome X.
DR RNAct; Q9ULE0; protein.
DR Bgee; ENSG00000047644; Expressed in secondary oocyte and 204 other tissues.
DR Genevisible; Q9ULE0; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IDA:BHF-UCL.
DR GO; GO:0019900; F:kinase binding; IPI:BHF-UCL.
DR GO; GO:0060090; F:molecular adaptor activity; IDA:BHF-UCL.
DR GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR GO; GO:0035331; P:negative regulation of hippo signaling; IDA:BHF-UCL.
DR GO; GO:0046621; P:negative regulation of organ growth; IMP:BHF-UCL.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:BHF-UCL.
DR GO; GO:0035330; P:regulation of hippo signaling; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd08680; C2_Kibra; 1.
DR Gene3D; 2.60.40.150; -; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037771; C2_WWC.
DR SUPFAM; SSF49562; SSF49562; 1.
DR PROSITE; PS50004; C2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..1092
FT /note="Protein WWC3"
FT /id="PRO_0000244494"
FT DOMAIN 598..723
FT /note="C2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT REGION 363..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 422..488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 510..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 40..126
FT /evidence="ECO:0000255"
FT COILED 230..344
FT /evidence="ECO:0000255"
FT COILED 761..812
FT /evidence="ECO:0000255"
FT COILED 967..1036
FT /evidence="ECO:0000255"
FT COMPBIAS 440..466
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 544..582
FT /note="TVTLREDSAKRLERRARRISACLSDYSLASDSGVFEPLT -> SKCSLSDSS
FT RRQCQEVGEEGTPHLRMSVGLFASQRQWGV (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_029220"
FT VAR_SEQ 583..1092
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_029221"
FT VARIANT 495
FT /note="A -> T (in dbSNP:rs5934750)"
FT /id="VAR_036969"
FT VARIANT 593
FT /note="Y -> C (in dbSNP:rs36076296)"
FT /id="VAR_036970"
FT VARIANT 831
FT /note="P -> L (in dbSNP:rs55787431)"
FT /id="VAR_062109"
SQ SEQUENCE 1092 AA; 122676 MW; 742C698715617C2C CRC64;
MDHINKLTQI EDPREQWRRE QERMLKEYLI VAQEALNAKK EIYQIKQQRF ELAQEEYQQL
HKMCEDDSRS YASSFSGYST NTKYDPHQIK AEIASRRDRL SRLKRELTQM KQELQYKEKG
VETLQEIDRK MSSTHTSYKL DEAQAIMSEL RTIKKAICTG EKERRDLMHS LAKLTDSFKN
SCSVTDSLVD FPHHVGVPGD AGVPQQFCDA GSQTDIIGEF VFDDKTRLVD RVRLNWQYEE
ARKRVANIQQ QLARLDNESW PSTAEADRDR LQLIKEKEAL LQELQLIIAQ RRSAGDVARL
EEERERLEEE LRRARATSAQ GATERILLQE KRNCLLMQLE EATRLTSYLQ SQLKSLCAST
LTVSSGSSRG SLASSRGSLA SSRGSLSSVS FTDIYGLPQY EKPDAEGSQL LRFDLIPFDS
LGRDAPFSEP PGPSGFHKQR RSLDTPQSLA SLSSRSSLSS LSPPSSPLDT PFLPASRDSP
LAQLADSCEG PGLGALDRLR AHASAMGDED LPGMAALQPH GVPGDGEGPH ERGPPPASAP
VGGTVTLRED SAKRLERRAR RISACLSDYS LASDSGVFEP LTKRNEDAEE PAYGDTASNG
DPQIHVGLLR DSGSECLLVH VLQLKNPAGL AVKEDCKVHI RVYLPPLDSG TPNTYCSKAL
EFQVPLVFNE VFRIPVHSSA LTLKSLQLYV CSVTPQLQEE LLGIAQINLA DYDSLSEMQL
RWHSVQVFTS SEPSRTREAG CAGESSARDP AHTISISGKT DAVTVLLART TAQLQAVERE
LAEERAKLEY TEEEVLEMER KEEQAEAISE RSWQADSVDS GCSNCTQTSP PYPEPCCMGI
DSILGHPFAA QAGPYSPEKF QPSPLKVDKE TNTEDLFLEE AASLVKERPS RRARGSPFVR
SGTIVRSQTF SPGARSQYVC RLYRSDSDSS TLPRKSPFVR NTLERRTLRY KQSCRSSLAE
LMARTSLDLE LDLQASRTRQ RQLNEELCAL RELRQRLEDA QLRGQTDLPP WVLRDERLRG
LLREAERQTR QTKLDYRHEQ AAEKMLKKAS KEIYQLRGQS HKEPIQVQTF REKIAFFTRP
RINIPPLPAD DV
