WWOX_CHICK
ID WWOX_CHICK Reviewed; 414 AA.
AC Q5F389;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 2.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=WW domain-containing oxidoreductase;
DE EC=1.1.1.-;
GN Name=WWOX; ORFNames=RCJMB04_28b1;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=CB; TISSUE=Bursa of Fabricius;
RX PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA Hayashizaki Y., Buerstedde J.-M.;
RT "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT function analysis.";
RL Genome Biol. 6:R6.1-R6.9(2005).
CC -!- FUNCTION: Putative oxidoreductase. Acts as a tumor suppressor and plays
CC a role in apoptosis. May function synergistically with p53/TP53 to
CC control genotoxic stress-induced cell death. Plays a role in TGFB1
CC signaling and TGFB1-mediated cell death. May also play a role in tumor
CC necrosis factor (TNF)-mediated cell death. Required for normal bone
CC development. Inhibits Wnt signaling (By similarity).
CC {ECO:0000250|UniProtKB:Q9NZC7}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9NZC7}. Nucleus
CC {ECO:0000250|UniProtKB:Q9NZC7}.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAH65395.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AJ851761; CAH65395.1; ALT_FRAME; mRNA.
DR RefSeq; NP_001025745.2; NM_001030574.2.
DR AlphaFoldDB; Q5F389; -.
DR SMR; Q5F389; -.
DR STRING; 9031.ENSGALP00000008618; -.
DR PaxDb; Q5F389; -.
DR GeneID; 415801; -.
DR KEGG; gga:415801; -.
DR CTD; 51741; -.
DR VEuPathDB; HostDB:geneid_415801; -.
DR eggNOG; KOG1208; Eukaryota.
DR InParanoid; Q5F389; -.
DR OrthoDB; 1413827at2759; -.
DR PhylomeDB; Q5F389; -.
DR PRO; PR:Q5F389; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005902; C:microvillus; IEA:Ensembl.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IEA:Ensembl.
DR GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0003713; F:transcription coactivator activity; IEA:Ensembl.
DR GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEA:Ensembl.
DR GO; GO:0097191; P:extrinsic apoptotic signaling pathway; IEA:Ensembl.
DR GO; GO:0072332; P:intrinsic apoptotic signaling pathway by p53 class mediator; IEA:Ensembl.
DR GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0001649; P:osteoblast differentiation; IEA:Ensembl.
DR GO; GO:2001241; P:positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0048705; P:skeletal system morphogenesis; IEA:Ensembl.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd09809; human_WWOX_like_SDR_c-like; 1.
DR CDD; cd00201; WW; 2.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR002347; SDR_fam.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR InterPro; IPR042732; WWOX_SDR_c-like.
DR Pfam; PF00106; adh_short; 1.
DR Pfam; PF00397; WW; 2.
DR PRINTS; PR00081; GDHRDH.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF51045; SSF51045; 2.
DR SUPFAM; SSF51735; SSF51735; 1.
DR PROSITE; PS01159; WW_DOMAIN_1; 2.
DR PROSITE; PS50020; WW_DOMAIN_2; 2.
PE 2: Evidence at transcript level;
KW Apoptosis; Cytoplasm; NADP; Nucleus; Oxidoreductase; Phosphoprotein;
KW Reference proteome; Repeat; Wnt signaling pathway.
FT CHAIN 1..414
FT /note="WW domain-containing oxidoreductase"
FT /id="PRO_0000054818"
FT DOMAIN 16..49
FT /note="WW 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00224"
FT DOMAIN 57..90
FT /note="WW 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00224"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 50..55
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000250"
FT ACT_SITE 293
FT /note="Proton acceptor"
FT /evidence="ECO:0000250"
FT BINDING 131..137
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250"
FT BINDING 260
FT /ligand="substrate"
FT /evidence="ECO:0000250"
SQ SEQUENCE 414 AA; 46730 MW; 8752D52FBDA29837 CRC64;
MAALKYAGLE DTDSEEELPP GWEERTTKDG WVYYANHLEE KTQWEHPKSG KRKRVAGGLP
YGWEQETDEN GQVYFVDHIN KRTTYLDPRL AFTVEDNPAK PPTRQKYDGN STAMEILQGR
DLSGKVIIIT GANSGIGFET AKSFALHGAY VILACRNMSR GNDAVQRILE EWHKAKVEAM
TLDLASLRSV QNFAEAFKSK NMPLHILVCN AAIFGSSWCL TEDGLESTFQ VNHLGHFYLV
QLLEDILRRS SPARVVVVSS ESHRFTEIKD SSGKLDFSLL SPSKKEYWAM LAYNRSKLCN
ILFSNELNRR LSPHGVTSNS VHPGNMIYSS IHRNWWVYTL LFTLARPFTK SMQQGAATTV
YCATAAELEG LGGMYFNNCC RCLPSAEARN ELTAVALWEL SERLIREQLG RRSP
