ID   WZA_SALTI               Reviewed;         379 AA.
AC   Q8Z5G4;
DT   27-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT   27-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 114.
DE   RecName: Full=Putative polysaccharide export protein wza;
DE   Flags: Precursor;
GN   Name=wza; OrderedLocusNames=STY2331, t0754;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- FUNCTION: Probably involved in the export of the extracellular
CC       polysaccharide colanic acid from the cell to medium. {ECO:0000250}.
CC   -!- PATHWAY: Glycan metabolism; exopolysaccharide biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the BexD/CtrA/VexA family. {ECO:0000305}.
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DR   EMBL; AL513382; CAD02481.1; -; Genomic_DNA.
DR   EMBL; AE014613; AAO68447.1; -; Genomic_DNA.
DR   RefSeq; NP_456664.1; NC_003198.1.
DR   RefSeq; WP_000978074.1; NZ_WSUR01000002.1.
DR   AlphaFoldDB; Q8Z5G4; -.
DR   SMR; Q8Z5G4; -.
DR   STRING; 220341.16503345; -.
DR   EnsemblBacteria; AAO68447; AAO68447; t0754.
DR   KEGG; stt:t0754; -.
DR   KEGG; sty:STY2331; -.
DR   PATRIC; fig|220341.7.peg.2352; -.
DR   eggNOG; COG1596; Bacteria.
DR   HOGENOM; CLU_038343_4_2_6; -.
DR   OMA; TKGGQFY; -.
DR   UniPathway; UPA00631; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046930; C:pore complex; IEA:UniProtKB-KW.
DR   GO; GO:0015159; F:polysaccharide transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015288; F:porin activity; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR003715; Poly_export.
DR   InterPro; IPR019554; Soluble_ligand-bd.
DR   InterPro; IPR040716; Wza_C.
DR   Pfam; PF02563; Poly_export; 1.
DR   Pfam; PF10531; SLBB; 1.
DR   Pfam; PF18412; Wza_C; 1.
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Exopolysaccharide synthesis; Ion transport;
KW   Lipoprotein; Membrane; Palmitate; Polysaccharide transport; Porin; Signal;
KW   Sugar transport; Transmembrane; Transmembrane beta strand; Transport.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   CHAIN           21..379
FT                   /note="Putative polysaccharide export protein wza"
FT                   /id="PRO_0000025224"
FT   LIPID           21
FT                   /note="N-palmitoyl cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
FT   LIPID           21
FT                   /note="S-diacylglycerol cysteine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00303"
SQ   SEQUENCE   379 AA;  41705 MW;  B785C49FA779C1D4 CRC64;
     MMKSKMKLMP LLASLSLISG CTVLPGSNMS TMGKDVIKQQ DADFDLDRMV NVYPLTPRLV
     EQLRPRPNVA QPNMSLDQEI ASYQYRVGPG DVLNVTVWDH PELTTPAGQY RSSSDTGNWA
     QPDGTMFYPY IGKVSVVGKT LSEIRSDITG RLAKYIADPQ VDVNIAAFRS QKAYISGQVN
     KSGQQAITNV PLTVLDAINA AGGLTDMADW RNVVLTHNGK EQRISLQALM QNGDLSQNRL
     LYPGDILYVP RNDDLKVFVM GEVKKQSTLK MDFSSMTLTE ALGNAEGIDL TTSNASGIFV
     IRPLKGEGGR GGKIANIYQL DMSDATSLVM ATEFRLQPYD VVYVTTAPVA RWNRLINQLL
     PTISGVRYMT DTASDIHSW