CAND1_CAEEL
ID CAND1_CAEEL Reviewed; 1274 AA.
AC G5ED41;
DT 01-MAY-2013, integrated into UniProtKB/Swiss-Prot.
DT 14-DEC-2011, sequence version 1.
DT 03-AUG-2022, entry version 66.
DE RecName: Full=Cullin-associated NEDD8-dissociated protein 1;
DE AltName: Full=Cullin-associated and neddylation-dissociated protein 1;
GN Name=cand-1; ORFNames=Y102A5A.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE,
RP AND INTERACTION WITH CUL-1; CUL-2; CUL-3; CUL-4; CUL-5 AND CUL-6.
RX PubMed=20659444; DOI=10.1016/j.ydbio.2010.07.020;
RA Bosu D.R., Feng H., Min K., Kim Y., Wallenfang M.R., Kipreos E.T.;
RT "C. elegans CAND-1 regulates cullin neddylation, cell proliferation and
RT morphogenesis in specific tissues.";
RL Dev. Biol. 346:113-126(2010).
CC -!- FUNCTION: Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3
CC ubiquitin ligase complexes that promotes the exchange of the substrate-
CC recognition F-box subunit in SCF complexes, thereby playing a key role
CC in the cellular repertoire of SCF complexes. Acts as a F-box protein
CC exchange factor (Probable). {ECO:0000305|PubMed:20659444}.
CC -!- SUBUNIT: Interacts with cul-1, cul-2, cul-3, cul-4, cul-5 and cul-6.
CC {ECO:0000269|PubMed:20659444}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20659444}.
CC -!- DEVELOPMENTAL STAGE: In early embryos, expressed in all cells.
CC Expression is higher during early stages and is reduced in late-stage
CC embryos. Present in the one-cell stage zygote, indicating it is
CC provided as a maternal product by the hermaphrodite parent. During
CC larval stages, expressed in proliferative cell lineages, including the
CC seam cells, intestine, P-lineage cells, somatic gonad, and germline.
CC Also observed in a subset of non-proliferative tissues, including
CC hypodermal cells (at protein level). {ECO:0000269|PubMed:20659444}.
CC -!- DISRUPTION PHENOTYPE: Worms show impenetrant phenotypes, including
CC developmental arrest, morphological defects of the vulva and tail and
CC reduced fecundity. Worms also display supernumerary seam cell
CC divisions, defective alae formation, and the accumulation of the
CC SCF(lin-23) target, the glutamate receptor glr-1. Increased levels of
CC the neddylated isoforms of Cul-2 and cul-4.
CC {ECO:0000269|PubMed:20659444}.
CC -!- SIMILARITY: Belongs to the CAND family. {ECO:0000305}.
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DR EMBL; AL023822; CAA19440.1; -; Genomic_DNA.
DR EMBL; Z81593; CAA19440.1; JOINED; Genomic_DNA.
DR PIR; T25024; T25024.
DR RefSeq; NP_507244.1; NM_074843.5.
DR AlphaFoldDB; G5ED41; -.
DR SMR; G5ED41; -.
DR BioGRID; 45111; 7.
DR IntAct; G5ED41; 1.
DR STRING; 6239.Y102A5A.1; -.
DR EPD; G5ED41; -.
DR PaxDb; G5ED41; -.
DR PeptideAtlas; G5ED41; -.
DR EnsemblMetazoa; Y102A5A.1.1; Y102A5A.1.1; WBGene00013606.
DR GeneID; 180125; -.
DR KEGG; cel:CELE_Y102A5A.1; -.
DR CTD; 180125; -.
DR WormBase; Y102A5A.1; CE20378; WBGene00013606; cand-1.
DR eggNOG; KOG1824; Eukaryota.
DR GeneTree; ENSGT00390000017740; -.
DR HOGENOM; CLU_007157_0_0_1; -.
DR InParanoid; G5ED41; -.
DR OMA; MGGTQDD; -.
DR OrthoDB; 194023at2759; -.
DR PhylomeDB; G5ED41; -.
DR Reactome; R-CEL-6798695; Neutrophil degranulation.
DR Reactome; R-CEL-8951664; Neddylation.
DR Reactome; R-CEL-917937; Iron uptake and transport.
DR PRO; PR:G5ED41; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00013606; Expressed in embryo and 4 other tissues.
DR GO; GO:0005634; C:nucleus; IDA:WormBase.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR GO; GO:0060625; P:regulation of protein deneddylation; IMP:WormBase.
DR GO; GO:0010265; P:SCF complex assembly; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039852; CAND1/CAND2.
DR InterPro; IPR013932; TATA-bd_TIP120.
DR PANTHER; PTHR12696; PTHR12696; 1.
DR Pfam; PF08623; TIP120; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome; Repeat; Ubl conjugation pathway.
FT CHAIN 1..1274
FT /note="Cullin-associated NEDD8-dissociated protein 1"
FT /id="PRO_0000422240"
FT REPEAT 41..79
FT /note="HEAT 1"
FT REPEAT 127..167
FT /note="HEAT 2"
FT REPEAT 375..413
FT /note="HEAT 3"
FT REPEAT 500..540
FT /note="HEAT 4"
FT REPEAT 617..655
FT /note="HEAT 5"
FT REPEAT 671..709
FT /note="HEAT 6"
FT REPEAT 1000..1038
FT /note="HEAT 7"
FT REPEAT 1041..1078
FT /note="HEAT 8"
FT REPEAT 1079..1117
FT /note="HEAT 9"
FT REGION 320..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..348
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1274 AA; 141726 MW; 4D0D62BAD14B83D2 CRC64;
MSAYHVGQLV DKMSNPDKDF RFMACNDLMK DLQTGTIALE DDSTAKVIRA LIKLLSDSNG
EVQNLAIKCI GLLAQPSKIK THHLEYLVEE LTPHVFSKAE QSRDIHSLTL KAMILNLAPS
ASSNATTTVV KRMLPKFVDS LSLCAPDDAA RVDVLDLIGE VLLRFGDVVP EMHKGSLKVM
VDHLYSFRSA IRKKAITGIG HLASVINGEL YDELVQDLLK ELAQRSPPSS AAQNVQLRTL
VIALSTVARA SGSRFSKHTP KVVPFLLQYL QIDPGTESEH DDLREASIQG LEVFLYRNPQ
EVVAFEKEVI QQLTDALAYD PNYEYGDDDE DEQMEDDEDD DEDEYSDDED VTWKVRRAAA
KAIEAMISSH RESLLNLSQK IGPVVIGRFK EREETVRTEI ISVYIALLNQ ISILVPDLQK
AVVAADEDSI ETDDIVVIGG TKFSTNYLSR SQLAIIQSLA DQKDVLLRTI TKSMKKHPKT
GPKCIELLSA LIRTYPSGLE DSLDDIIPAV SNILTDKNAS AQGKMTVLSF ISNALTLNNP
KRFKNLLSPL TTIMTHSISE PFYKVSAEGL AVCCKYIDVL RELSACGGNE EAKKLLVVVE
KKFMANDTDQ EVRERAISAI SMLLAAFKDV LKNETPAILE KMTERIGRDM TCLVAFRAST
HIVEAGIIFS SAQLQSILRH VVDYVKKIAR SLRMTCLNFV EKLMKHSPAG SIPVEELTCV
LGEMSNLISE TDLQITNQAF CCLTYAFLNF PTCVSLHMQP ILDSIIRLLT SPLIQGLALN
SLLNLFTAIV KTDFPEKPTF ESLLDSVTSP VYDNVALSRH AHMAIASCAA VITESTQNLE
KSRSLAKKLA QQLQTANMSD SIRLFAMITL GELGRRVPDT YSPDFPVKPE DLAIKAFNHH
HEDLKSAAAQ ALGALAVGNL NVYLPFILEQ IRTQPKKQYL LLHALKEVIV WESSSEESTK
STDLFRSAIV DIWGMLMANA GGNEDGTRSV VAECLGRLCS FDPESLLPKL KESMRSSDPA
IRSSAVSAIK YMINDEKRIV DITLQKQIGD FLAAVRDEDL KVRRVALVVL NSAAHNKPAL
VRDLLPDLLP AVYEETKLRK ELIKEVEMGP FKHQVDEGLD LRKCAFECMF TLLESCVDKI
DITQFSSVME VGLSDQNHDV KLLNYLTLQR VANLAPGQVL QRIDRVCEPL KTQLNVRPRG
NAVKQEVEKL EELKKAVIRV VYGLKLKLPE VERNPQFLDL YNTIKHTKEL EALANDVLKE
SQRAVVYDTP META
