ID   WZYE_SALNS              Reviewed;         452 AA.
AC   B4SZ39;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Probable ECA polymerase {ECO:0000255|HAMAP-Rule:MF_01003};
GN   Name=wzyE {ECO:0000255|HAMAP-Rule:MF_01003};
GN   OrderedLocusNames=SNSL254_A4208;
OS   Salmonella newport (strain SL254).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=423368;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SL254;
RX   PubMed=21602358; DOI=10.1128/jb.00297-11;
RA   Fricke W.F., Mammel M.K., McDermott P.F., Tartera C., White D.G.,
RA   Leclerc J.E., Ravel J., Cebula T.A.;
RT   "Comparative genomics of 28 Salmonella enterica isolates: evidence for
RT   CRISPR-mediated adaptive sublineage evolution.";
RL   J. Bacteriol. 193:3556-3568(2011).
CC   -!- FUNCTION: Probably involved in the polymerization of enterobacterial
CC       common antigen (ECA) trisaccharide repeat units. {ECO:0000255|HAMAP-
CC       Rule:MF_01003}.
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; enterobacterial common
CC       antigen biosynthesis. {ECO:0000255|HAMAP-Rule:MF_01003}.
CC   -!- SUBUNIT: Probably part of a complex composed of WzxE, WzyE and WzzE.
CC       {ECO:0000255|HAMAP-Rule:MF_01003}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01003}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01003}.
CC   -!- SIMILARITY: Belongs to the WzyE family. {ECO:0000255|HAMAP-
CC       Rule:MF_01003}.
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DR   EMBL; CP001113; ACF61556.1; -; Genomic_DNA.
DR   RefSeq; WP_000055610.1; NZ_CCMR01000001.1.
DR   AlphaFoldDB; B4SZ39; -.
DR   EnsemblBacteria; ACF61556; ACF61556; SNSL254_A4208.
DR   KEGG; see:SNSL254_A4208; -.
DR   HOGENOM; CLU_049711_0_0_6; -.
DR   OMA; WLWPDRP; -.
DR   UniPathway; UPA00566; -.
DR   Proteomes; UP000008824; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0009246; P:enterobacterial common antigen biosynthetic process; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01003; WzyE; 1.
DR   InterPro; IPR010691; WzyE.
DR   Pfam; PF06899; WzyE; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..452
FT                   /note="Probable ECA polymerase"
FT                   /id="PRO_1000200217"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01003"
FT   TRANSMEM        37..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01003"
FT   TRANSMEM        63..83
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01003"
FT   TRANSMEM        118..138
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01003"
FT   TRANSMEM        155..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01003"
FT   TRANSMEM        181..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01003"
FT   TRANSMEM        207..227
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01003"
FT   TRANSMEM        228..248
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01003"
FT   TRANSMEM        341..361
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01003"
FT   TRANSMEM        378..398
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01003"
FT   TRANSMEM        410..430
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01003"
SQ   SEQUENCE   452 AA;  51666 MW;  EA9720F0F3061AD1 CRC64;
     MSLMQFSGLL VVWLLSTLFI ATLTWFEFRR VRFNFNVFFS LLFLLTFFFG FPLTSVLVFR
     FDVGVAPPEI LLQALLSAAC FYGVYYVTYK TRLRKRVVDV PRKPLFTMNR VETHLTWVIL
     MGIALVSVAI FFMHNGFLLF RLHSYSQIFS SEVSGVALKR FFYFFIPAML VVYFLRQDSK
     AWLFFLVSTV AFGLLTYMIV GGTRANIIIA FAIFLFIGII RGWISLWMLA AAGVLGIVGM
     FWLALKRYGL NVSGDEAFYT FLYLTRDTFS PWENLALLLQ NYHNIEFQGL APIVRDFYVF
     IPTWLWPGRP SIVLNSANYF TWEVLNNHSG LAISPTLIGS LVVMGGALFI PLGAIVVGMI
     IKWFDWLYEL GNREPNRYKA AILHSFCFGA IFNMIVLARE GLDSFVSRVV FFLVVFGASL
     LVAKLLFWLF DSAGLIHKRT TSLPQAQVEG KL