WZYE_SALTI
ID WZYE_SALTI Reviewed; 452 AA.
AC Q8Z396;
DT 05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT 05-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 105.
DE RecName: Full=Probable ECA polymerase {ECO:0000255|HAMAP-Rule:MF_01003};
GN Name=wzyE {ECO:0000255|HAMAP-Rule:MF_01003}; Synonyms=rffT;
GN OrderedLocusNames=STY3627, t3369;
OS Salmonella typhi.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=90370;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CT18;
RX PubMed=11677608; DOI=10.1038/35101607;
RA Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA Barrell B.G.;
RT "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT serovar Typhi CT18.";
RL Nature 413:848-852(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700931 / Ty2;
RX PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT CT18.";
RL J. Bacteriol. 185:2330-2337(2003).
CC -!- FUNCTION: Probably involved in the polymerization of enterobacterial
CC common antigen (ECA) trisaccharide repeat units. {ECO:0000255|HAMAP-
CC Rule:MF_01003}.
CC -!- PATHWAY: Bacterial outer membrane biogenesis; enterobacterial common
CC antigen biosynthesis. {ECO:0000255|HAMAP-Rule:MF_01003}.
CC -!- SUBUNIT: Probably part of a complex composed of WzxE, WzyE and WzzE.
CC {ECO:0000255|HAMAP-Rule:MF_01003}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01003}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01003}.
CC -!- SIMILARITY: Belongs to the WzyE family. {ECO:0000255|HAMAP-
CC Rule:MF_01003}.
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DR EMBL; AL513382; CAD09388.1; -; Genomic_DNA.
DR EMBL; AE014613; AAO70893.1; -; Genomic_DNA.
DR RefSeq; NP_457819.1; NC_003198.1.
DR RefSeq; WP_000055604.1; NZ_WSUR01000032.1.
DR AlphaFoldDB; Q8Z396; -.
DR STRING; 220341.16504506; -.
DR EnsemblBacteria; AAO70893; AAO70893; t3369.
DR KEGG; stt:t3369; -.
DR KEGG; sty:STY3627; -.
DR PATRIC; fig|220341.7.peg.3696; -.
DR eggNOG; ENOG502Z7MA; Bacteria.
DR HOGENOM; CLU_049711_0_0_6; -.
DR OMA; WLWPDRP; -.
DR UniPathway; UPA00566; -.
DR Proteomes; UP000000541; Chromosome.
DR Proteomes; UP000002670; Chromosome.
DR GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR GO; GO:0009246; P:enterobacterial common antigen biosynthetic process; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01003; WzyE; 1.
DR InterPro; IPR010691; WzyE.
DR Pfam; PF06899; WzyE; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..452
FT /note="Probable ECA polymerase"
FT /id="PRO_0000208543"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01003"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01003"
FT TRANSMEM 63..83
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01003"
FT TRANSMEM 118..138
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01003"
FT TRANSMEM 155..175
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01003"
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01003"
FT TRANSMEM 207..227
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01003"
FT TRANSMEM 228..248
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01003"
FT TRANSMEM 341..361
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01003"
FT TRANSMEM 378..398
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01003"
FT TRANSMEM 410..430
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01003"
SQ SEQUENCE 452 AA; 51652 MW; 8EA5A44EE6064E3F CRC64;
MSLMQFSGLL VVWLLSTLFI ATLTWFEFRR VRFNFNVFFS LLFLLTFFFG FPLTSVLVFR
FDVGVAPPEI LLQALLSAAC FYGVYYVTYK TRLRKRVVDV PRKPLFTMNR VETHLTWVIL
MGIALVSVAI FFMHNGFLLF RLHSYSQIFS SEVSGVALKR FFYFFIPAML VVYFLRQDSK
AWLFFLVSTV AFGLLTYMIV GGTRANIIIA FAIFLFIGII RGWISLWMLA AAGVLGIVGM
FWLALKRYGL NVSGDEAFYT FLYLTRDTFS PWENLALLLQ NYHNIDFQGL APIVRDFYVF
IPTWLWPGRP SIVLNSANYF TWEVLNNHSG LAISPTLIGS LVVMGGALFI PLGAIVVGLI
IKWFDWLYEL GNREPNRYKA AILHSFCFGA IFNMIVLARE GLDSFVSRVV FFLVVFGASL
LVAKLLFWLF DSAGLIHKRT TSLPQAQMDG KL
